ES8304550A1 - "un procedimiento para preparar derivados de dialcohilpirazol". - Google Patents
"un procedimiento para preparar derivados de dialcohilpirazol".Info
- Publication number
- ES8304550A1 ES8304550A1 ES513398A ES513398A ES8304550A1 ES 8304550 A1 ES8304550 A1 ES 8304550A1 ES 513398 A ES513398 A ES 513398A ES 513398 A ES513398 A ES 513398A ES 8304550 A1 ES8304550 A1 ES 8304550A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- dialkylpyrazol
- methanones
- aryl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE DIALCOHILPIRAZOL Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R , R Y R SON HIDROGENO O ALCOHILO C <- ; R ES ALCOHILO C <- ; A, R , R Y AR PUEDEN SER VARIOS RADICALES Y A Y A VALEN 0-6. CONSISTE EN LA REACCION DE METALACION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO TAL COMO BUTILLITIO, SEGUIDA DE LA REACCION DEL DERIVADO LITIADO ASI OBTENIDO CON UN COMPUESTO DE FORMULA ARCOZ, EN LAS QUE Z ES UN HALOGENO, ALCOXI O UN GRUPO EQUIVALENTE Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN CONDICIONES ANHIDRAS, A UNA TEMPERATURA ENTRE -60 C Y 0 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIINFLAMATORIOS, ANALGESICOS Y RELAJANTES MUSCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27757781A | 1981-06-26 | 1981-06-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8304550A1 true ES8304550A1 (es) | 1983-03-01 |
ES513398A0 ES513398A0 (es) | 1983-03-01 |
Family
ID=23061477
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES513398A Granted ES513398A0 (es) | 1981-06-26 | 1982-06-23 | "un procedimiento para preparar derivados de dialcohilpirazol". |
ES513375A Expired ES8305350A1 (es) | 1981-06-26 | 1982-06-23 | "un procedimiento para preparar derivados de dialcohilpirazol". |
ES513399A Expired ES8304551A1 (es) | 1981-06-26 | 1982-06-23 | Un procedimiento para preparar derivados de dialcohilpirazol |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES513375A Expired ES8305350A1 (es) | 1981-06-26 | 1982-06-23 | "un procedimiento para preparar derivados de dialcohilpirazol". |
ES513399A Expired ES8304551A1 (es) | 1981-06-26 | 1982-06-23 | Un procedimiento para preparar derivados de dialcohilpirazol |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0068806A3 (es) |
JP (1) | JPS584771A (es) |
AU (1) | AU8515182A (es) |
DD (1) | DD202547A5 (es) |
DK (1) | DK282882A (es) |
ES (3) | ES513398A0 (es) |
FI (1) | FI822260L (es) |
GR (1) | GR76155B (es) |
IL (1) | IL66109A0 (es) |
NO (1) | NO822100L (es) |
ZA (1) | ZA824468B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ208555A (en) * | 1983-06-23 | 1987-06-30 | American Cyanamid Co | (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives |
DE3600950A1 (de) * | 1986-01-15 | 1987-07-16 | Bayer Ag | 5-acylamido-1-aryl-pyrazole |
FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3558605A (en) * | 1969-05-14 | 1971-01-26 | Parke Davis & Co | Pyrazolo(3,4-e)(1,4)diazepin-7-(1h)-one compounds |
BE735597A (en) * | 1969-07-03 | 1970-01-05 | 1-aryl 3 4-opt subst 5-aminoalkanoylamino-pyrazoles | |
FR2100973A1 (en) * | 1970-07-30 | 1972-03-24 | Yoshitomi Pharmaceutical | 5-Aminopyrazoles - with analgesic, antiinflammatory and muscle relaxant activity |
US3886143A (en) * | 1974-01-21 | 1975-05-27 | Parke Davis & Co | Oxazolo {8 3,2-D{9 pyrazolo{8 4,3-F{9 {0 {8 1,4{9 diazepin-6(7H)-one compounds |
-
1982
- 1982-06-23 ES ES513398A patent/ES513398A0/es active Granted
- 1982-06-23 IL IL66109A patent/IL66109A0/xx unknown
- 1982-06-23 ES ES513375A patent/ES8305350A1/es not_active Expired
- 1982-06-23 ES ES513399A patent/ES8304551A1/es not_active Expired
- 1982-06-23 ZA ZA824468A patent/ZA824468B/xx unknown
- 1982-06-23 FI FI822260A patent/FI822260L/fi not_active Application Discontinuation
- 1982-06-23 JP JP57106982A patent/JPS584771A/ja active Pending
- 1982-06-23 AU AU85151/82A patent/AU8515182A/en not_active Abandoned
- 1982-06-23 DD DD82241009A patent/DD202547A5/de unknown
- 1982-06-23 DK DK282882A patent/DK282882A/da not_active Application Discontinuation
- 1982-06-23 EP EP82303267A patent/EP0068806A3/en not_active Withdrawn
- 1982-06-23 GR GR68535A patent/GR76155B/el unknown
- 1982-06-23 NO NO822100A patent/NO822100L/no unknown
Also Published As
Publication number | Publication date |
---|---|
AU8515182A (en) | 1983-01-06 |
GR76155B (es) | 1984-08-03 |
ES513375A0 (es) | 1983-04-01 |
IL66109A0 (en) | 1982-09-30 |
FI822260A0 (fi) | 1982-06-23 |
NO822100L (no) | 1982-12-27 |
ES513399A0 (es) | 1983-03-01 |
DD202547A5 (de) | 1983-09-21 |
EP0068806A3 (en) | 1983-08-10 |
FI822260L (fi) | 1982-12-27 |
ES513398A0 (es) | 1983-03-01 |
ES8305350A1 (es) | 1983-04-01 |
EP0068806A2 (en) | 1983-01-05 |
ES8304551A1 (es) | 1983-03-01 |
JPS584771A (ja) | 1983-01-11 |
DK282882A (da) | 1982-12-27 |
ZA824468B (en) | 1983-04-27 |
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