ES8301188A1 - Un procedimiento para la produccion de un dl- amino acido o una sal correspondiente. - Google Patents
Un procedimiento para la produccion de un dl- amino acido o una sal correspondiente.Info
- Publication number
- ES8301188A1 ES8301188A1 ES509010A ES509010A ES8301188A1 ES 8301188 A1 ES8301188 A1 ES 8301188A1 ES 509010 A ES509010 A ES 509010A ES 509010 A ES509010 A ES 509010A ES 8301188 A1 ES8301188 A1 ES 8301188A1
- Authority
- ES
- Spain
- Prior art keywords
- salt
- amino acid
- racemizing
- optically active
- active alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/36—Racemisation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/44—Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DL-ALFA-AMINO ACIDO O SUS SALES CORRESPONDIENTES. CONSISTE EN RACEMIZAR UN <007>-AMINO ACIDO OPTICAMENTE ACTIVO O UNA SAL CORRESPONDIENTE EN PRESENCIA DE UN ACIDO ALIFATICO Y UN ALDEHID TALES COMO EL ACIDO ACETICO O EL ACIDO PROPIONICO O BIEN EL PROPIONALDEHIDO, EL N-BUTIRALDEHIDO, EL BENZALDEHIDO O EL SALICILALDEHIDO. LA TEMPERATURA DE REACCION OSCILA ENTRE 20 Y 120<025>C EMPLEANDOSE DE 0,001 A 0,5 MOLES DE ALDEHIDO POR MOL DE ALFA-AMINO ACIDO; DE DICHO ALFA-AMINO ACIDO SE SELECCIONA DE ENTRE LA ALANINA, LA VALLINA, LEUCINA, ISOLEUCINA, SERINA, TREONINA, CISTINA CISTEINA, TRIPTOFANO, FENILALANINA Y OTROS. LA REACCION TIENE LUGAR MEDIANTE AGITACION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP938081A JPS57123150A (en) | 1981-01-23 | 1981-01-23 | Racemization of aminoacid |
JP9576581A JPS57212146A (en) | 1981-06-19 | 1981-06-19 | Racemization of amino acid salt |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8301188A1 true ES8301188A1 (es) | 1982-12-01 |
ES509010A0 ES509010A0 (es) | 1982-12-01 |
Family
ID=26344074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES509010A Granted ES509010A0 (es) | 1981-01-23 | 1982-01-22 | Un procedimiento para la produccion de un dl- amino acido o una sal correspondiente. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4401820A (es) |
EP (1) | EP0057092B1 (es) |
KR (1) | KR860000339B1 (es) |
CA (1) | CA1176640A (es) |
DE (1) | DE3263329D1 (es) |
ES (1) | ES509010A0 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5810544A (ja) * | 1981-07-09 | 1983-01-21 | Tanabe Seiyaku Co Ltd | 光学活性p−ヒドロキシフエニルグリシン塩の製法 |
DE3209232A1 (de) * | 1982-03-13 | 1983-09-22 | Degussa Ag, 6000 Frankfurt | Verfahren zur racemisierung von optisch aktivem s-(carboxymethyl)-cystein |
FR2523961B1 (fr) * | 1982-03-23 | 1985-08-30 | Centre Nat Rech Scient | Procede de preparation d'un alpha-amino-acide libre l |
US4570017A (en) * | 1983-01-18 | 1986-02-11 | Shell Oil Company | Preparation of optically-active (mixed) anhydrides and acids |
DE3334849A1 (de) * | 1983-09-27 | 1985-04-04 | Hoechst Ag, 6230 Frankfurt | Verfahren zur racemisierung optisch aktiver aminosaeuren |
GB8421964D0 (en) * | 1984-08-30 | 1984-10-03 | Beecham Group Plc | Chemical process |
NL8501093A (nl) * | 1985-04-12 | 1986-11-03 | Stamicarbon | Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide. |
US4713470A (en) * | 1985-05-22 | 1987-12-15 | Stauffer Chemical Company | Racemization of amino acids |
US4766250A (en) * | 1985-05-22 | 1988-08-23 | Stauffer Chemical Co. | Racemization catalyst for amino acids |
JPH0780823B2 (ja) * | 1986-08-26 | 1995-08-30 | 東ソー株式会社 | 光学活性フェニルアラニンのラセミ化方法 |
JPS6440453A (en) * | 1987-08-05 | 1989-02-10 | Mitsui Toatsu Chemicals | Racemization of optically active serine |
NL9000387A (nl) | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor het racemiseren van een optisch aktief aminozuuramide. |
IL95038A (en) * | 1990-07-11 | 1995-10-31 | Bromine Compounds Ltd | Preparation of d-histidine and derivatives thereof by asymmetric transformation of l-histidine |
CA2048286A1 (en) * | 1990-08-06 | 1992-02-07 | Masatoshi Kawashima | Optical resolution method |
EP0499376A1 (en) * | 1991-01-31 | 1992-08-19 | Hoechst Celanese Corporation | Precipitation-induced asymmetric transformation of chiral alpha-amino acids and salts thereof |
EP0737683A1 (en) * | 1991-02-27 | 1996-10-16 | Pfizer Inc. | N-2-(Phthalimido)ethyl trans-piperidine-2,5-dicarboxylates as intermediates in the preparation of perhydro-1H-pyrido[1,2-a]pyrazines |
US5637713A (en) * | 1993-08-20 | 1997-06-10 | Pfizer Inc. | Process for preparing trans-piperidine-2,5-dicarboxylates |
DE4407197A1 (de) * | 1994-03-04 | 1995-09-07 | Hoechst Schering Agrevo Gmbh | Verfahren zur Herstellung von /L/-Homoalanin-4-yl-(methyl)phosphinsäure und deren Salze durch Racematspaltung |
CA2245543A1 (en) * | 1996-03-13 | 1997-09-18 | Fabienne Henzen | Process for producing n-protected d-proline derivatives 8 |
US6310242B1 (en) | 1998-02-20 | 2001-10-30 | Yamakawa Chemical Industry Co., Ltd. | Process for preparing D-alloisoleucine and intermediates for preparation |
EP1228037A4 (en) * | 1999-10-29 | 2004-06-02 | Picower Inst Med Res | COMPOUNDS HAVING ANTIAGONIST ACTIVITY OF MIF |
US6794537B1 (en) * | 2002-11-07 | 2004-09-21 | Sami Labs Limited | Manufacturing processes for Se-methyl-L-selenocysteine |
CN1293041C (zh) * | 2003-05-30 | 2007-01-03 | 上海实业化工有限公司 | D-(-)-1-苯甘氨酸的制备方法 |
CN101759607A (zh) * | 2008-12-04 | 2010-06-30 | 河南新天地药业有限公司 | D-(-)-对羟基苯甘氨酸对甲基苯磺酸盐水解后母液结盐技术 |
CN102617384A (zh) * | 2012-03-06 | 2012-08-01 | 四川同晟氨基酸有限公司 | N-酰基-dl-亮氨酸的制备方法及用途 |
CN102875401B (zh) * | 2012-10-30 | 2014-12-31 | 宜兴市前成生物有限公司 | 一种以废天冬为原料生产dl-天门冬氨酸的方法 |
FR3000489B1 (fr) * | 2013-01-02 | 2014-12-26 | Holis Technologies | Procede de racemisation de la l-lysine, utilisation du produit obtenu et installation pour la mise en oeuvre du procede |
KR101561828B1 (ko) | 2013-08-23 | 2015-10-20 | 주식회사 아미노로직스 | α-아미노산의 라세미화 방법 |
CN104140377A (zh) * | 2014-07-10 | 2014-11-12 | 浙江大学 | 一种消旋体茶氨酸的制备方法 |
CN104478746B (zh) * | 2014-12-16 | 2016-06-15 | 武汉大学 | 一种dl-赖氨酸的制备方法 |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
US11845798B2 (en) | 2017-05-02 | 2023-12-19 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
CN108456145A (zh) * | 2017-09-15 | 2018-08-28 | 南通紫琅生物医药科技有限公司 | 一种母液可回收利用的dl-苯丙氨酸生产工艺 |
CN111836800B (zh) * | 2020-06-18 | 2021-11-05 | 苏州园方生物科技有限公司 | 一种dl-脯氨酸的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2071327A (en) * | 1935-08-15 | 1937-02-23 | Rudolph S Bley | Process of racemizing amino acids |
US3458568A (en) * | 1965-02-19 | 1969-07-29 | Toa Gosei Chem Ind | Process for preparing an optically inactive amino acid from an optically active amino acid |
JPS4919276B1 (es) * | 1969-04-14 | 1974-05-16 | ||
BE795874A (fr) * | 1972-02-25 | 1973-08-23 | Glaxo Lab Ltd | Procede de preparation d'esters optiquement actifs d'alpha-amino-acides |
NL7514301A (nl) * | 1975-12-09 | 1977-06-13 | Stamicarbon | Werkwijze voor het racemiseren van een optisch actief fenylglycine-amide met eventueel een ge- substitueerde fenylgroep. |
-
1982
- 1982-01-05 US US06/337,322 patent/US4401820A/en not_active Expired - Fee Related
- 1982-01-20 CA CA000394505A patent/CA1176640A/en not_active Expired
- 1982-01-22 ES ES509010A patent/ES509010A0/es active Granted
- 1982-01-22 DE DE8282300322T patent/DE3263329D1/de not_active Expired
- 1982-01-22 EP EP82300322A patent/EP0057092B1/en not_active Expired
- 1982-01-23 KR KR8200294A patent/KR860000339B1/ko active
Also Published As
Publication number | Publication date |
---|---|
CA1176640A (en) | 1984-10-23 |
EP0057092A1 (en) | 1982-08-04 |
KR860000339B1 (ko) | 1986-04-12 |
US4401820A (en) | 1983-08-30 |
EP0057092B1 (en) | 1985-05-02 |
KR830009016A (ko) | 1983-12-17 |
DE3263329D1 (en) | 1985-06-05 |
ES509010A0 (es) | 1982-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |