ES8300727A1 - "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". - Google Patents

"procedimiento para la preparacion de 3,1-benzoxazin-2-onas".

Info

Publication number
ES8300727A1
ES8300727A1 ES508655A ES508655A ES8300727A1 ES 8300727 A1 ES8300727 A1 ES 8300727A1 ES 508655 A ES508655 A ES 508655A ES 508655 A ES508655 A ES 508655A ES 8300727 A1 ES8300727 A1 ES 8300727A1
Authority
ES
Spain
Prior art keywords
group
hydrogen
alkyl
methyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES508655A
Other languages
English (en)
Other versions
ES508655A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES508655A0 publication Critical patent/ES508655A0/es
Publication of ES8300727A1 publication Critical patent/ES8300727A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 3,1-BENZOXAZIN-2-ONAS Y DE SUS SALES DE ADICION DE ACIDOS, EN FORMA DE RACEMATOS, ANTIPODAS DIASTEREOISOMEROS Y ENANTIOMEROS, DE FORMULA (I), EN LA QUE R Y R-W SON HIDROGENO O ALCOHILO C <003> ; R Y R SON HIDROGENO O METILO; R , R Y R PUEDEN SER VARIOS RADICALES, Y N VALE DE 1 A 3. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UNA AMINA DE FORMULA R NH EN LAS QUE R ES HIDROGENO O ALCOHILO; R T ES ALCOHILO O ARALCOHILO; R PUEDE SER VARIOS RADICALES; Y N Y R <024>R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE TAL COMO METANOL, A LA TEMPERATURA AMBIENTE. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOTENSOR Y TOCOLITICO, Y COMO BRONCOLITICOS, VASODILATADORES Y AGENTES CARDIACOS.
ES508655A 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas". Expired ES8300727A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803026534 DE3026534A1 (de) 1980-07-12 1980-07-12 3,1-benzoxazin-2-one, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES508655A0 ES508655A0 (es) 1982-11-01
ES8300727A1 true ES8300727A1 (es) 1982-11-01

Family

ID=6107085

Family Applications (4)

Application Number Title Priority Date Filing Date
ES503837A Expired ES8205402A1 (es) 1980-07-12 1981-07-10 Procedimiento para la preparacion de 3,1-benzoxazin-2-onas
ES508653A Expired ES8300725A1 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".
ES508654A Granted ES508654A0 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".
ES508655A Expired ES8300727A1 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES503837A Expired ES8205402A1 (es) 1980-07-12 1981-07-10 Procedimiento para la preparacion de 3,1-benzoxazin-2-onas
ES508653A Expired ES8300725A1 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".
ES508654A Granted ES508654A0 (es) 1980-07-12 1982-01-12 "procedimiento para la preparacion de 3,1-benzoxazin-2-onas".

Country Status (25)

Country Link
US (1) US4341778A (es)
EP (1) EP0043940B1 (es)
JP (1) JPS5748975A (es)
KR (1) KR850000755B1 (es)
AT (1) ATE9336T1 (es)
AU (1) AU540916B2 (es)
CA (1) CA1165317A (es)
DD (1) DD202018A5 (es)
DE (2) DE3026534A1 (es)
DK (1) DK149851C (es)
ES (4) ES8205402A1 (es)
FI (1) FI74703C (es)
GB (1) GB2080296B (es)
GR (1) GR74333B (es)
HK (1) HK98286A (es)
HU (1) HU183515B (es)
IE (1) IE52508B1 (es)
IL (1) IL63285A (es)
NO (1) NO158578C (es)
NZ (1) NZ197678A (es)
PH (1) PH17425A (es)
PT (1) PT73338B (es)
SG (1) SG77686G (es)
YU (1) YU170181A (es)
ZA (1) ZA814687B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446319A (en) * 1981-04-28 1984-05-01 Takeda Chemical Industries, Ltd. Aminocyclitols and their production
JPS62238288A (ja) * 1986-04-04 1987-10-19 Nippon Tokushu Noyaku Seizo Kk 環状カルバメ−ト及び農園芸用殺菌剤
FR2636065B1 (fr) * 1988-09-08 1993-05-07 Fabre Sa Pierre Nouveaux derives de dihydro-2,3 arylacoylaminoalcoyl-3 4h-benzoxazine-1,3 ones-4, leur preparation et leur application en tant que medicaments utiles en therapeutique
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
FR2680172B1 (fr) * 1991-08-05 1993-11-19 Fabre Medicament Pierre Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
CA2210138A1 (en) * 1995-01-24 1996-08-01 Peter D. Williams Tocolytic oxytocin receptor antagonists
US5874430A (en) * 1996-10-02 1999-02-23 Dupont Pharmaceuticals Company 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same
DE102004003428A1 (de) 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
US20100160304A1 (en) * 2005-01-19 2010-06-24 Dainippon Sumitomo Pharma Co., Ltd Aromatic sulfone compound as aldosterone receptor modulator
DE102005008921A1 (de) * 2005-02-24 2006-08-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von Atemwegserkrankungen
US7423146B2 (en) * 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
JP2010501520A (ja) * 2006-08-22 2010-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 光学異性的に純粋なベータ作動薬を含む吸入用粉末製剤
UY30552A1 (es) * 2006-08-22 2008-03-31 Boehringer Ingelheim Int Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones
PE20080425A1 (es) * 2006-08-22 2008-06-16 Boehringer Ingelheim Int Formulacion aerosol para la inhalacion de beta-agonistas
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3526621A (en) * 1966-08-03 1970-09-01 Farmaceutical Italia Soc Substituted 3,1-benzoxazin-2-one
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4163053A (en) * 1977-12-27 1979-07-31 Schering Corporation Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides
DD144050A5 (de) * 1978-06-05 1980-09-24 Ciba Geigy Ag Verfahren zur herstellung von n-alkylierten aminoalkoholen
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen

Also Published As

Publication number Publication date
PT73338B (en) 1983-06-20
YU170181A (en) 1983-10-31
AU7273181A (en) 1982-09-16
DE3166003D1 (en) 1984-10-18
EP0043940B1 (de) 1984-09-12
GB2080296B (en) 1983-09-28
KR830006248A (ko) 1983-09-20
ES503837A0 (es) 1982-06-01
AU540916B2 (en) 1984-12-06
ZA814687B (en) 1983-03-30
NO812355L (no) 1982-01-13
HU183515B (en) 1984-05-28
NO158578B (no) 1988-06-27
SG77686G (en) 1987-02-27
ES508653A0 (es) 1982-11-01
IL63285A0 (en) 1981-10-30
EP0043940A1 (de) 1982-01-20
ES508655A0 (es) 1982-11-01
ES8300726A1 (es) 1982-11-01
GR74333B (es) 1984-06-25
JPS5748975A (en) 1982-03-20
KR850000755B1 (en) 1985-05-25
US4341778A (en) 1982-07-27
NO158578C (no) 1988-10-05
DK306781A (da) 1982-01-13
DK149851B (da) 1986-10-13
ES508654A0 (es) 1982-11-01
FI74703B (fi) 1987-11-30
DD202018A5 (de) 1983-08-24
IE811567L (en) 1982-01-12
HK98286A (en) 1986-12-24
IE52508B1 (en) 1987-11-25
IL63285A (en) 1985-03-31
NZ197678A (en) 1984-12-14
ATE9336T1 (de) 1984-09-15
PT73338A (de) 1981-08-01
DK149851C (da) 1987-05-04
DE3026534A1 (de) 1982-03-18
PH17425A (en) 1984-08-08
FI74703C (fi) 1988-03-10
ES8300725A1 (es) 1982-11-01
ES8205402A1 (es) 1982-06-01
GB2080296A (en) 1982-02-03
FI812183L (fi) 1982-01-13
CA1165317A (en) 1984-04-10

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