ES8300089A1 - Procedimiento para preparar nuevos derivados de acidos 16-hidroxiprostanoicos 4,5-insaturados. - Google Patents

Procedimiento para preparar nuevos derivados de acidos 16-hidroxiprostanoicos 4,5-insaturados.

Info

Publication number
ES8300089A1
ES8300089A1 ES507577A ES507577A ES8300089A1 ES 8300089 A1 ES8300089 A1 ES 8300089A1 ES 507577 A ES507577 A ES 507577A ES 507577 A ES507577 A ES 507577A ES 8300089 A1 ES8300089 A1 ES 8300089A1
Authority
ES
Spain
Prior art keywords
unsaturated
acid derivatives
prostanoic acid
prostanoic
pharmacological properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507577A
Other languages
English (en)
Other versions
ES507577A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES8300089A1 publication Critical patent/ES8300089A1/es
Publication of ES507577A0 publication Critical patent/ES507577A0/es
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/90Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/80Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings
    • C07C59/82Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings the keto group being part of a ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16Radicals substituted by halogen atoms or nitro radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)

Abstract

UN METODO DE FILTRAR UNA SEÑAL DE TENSION DE ENTRADA CON UN CIRCUITO FILTRANTE. CONSTA DE LAS SIGUIENTES ETAPAS: 1<002> COMPARAR LA SEÑAL DE ENTRADA CON OTRA ANALOGICA DE SALIDA DE REALIMENTACION EN UN CIRCUITO SUMADOR PARA OBTENER UNA SEÑAL DE ERROR REPRESENTATIVA DE LA DIFERENCIA DE DICHAS SEÑALES DE RETROACCION. 2<002> GENERAR POR MEDIO DE UN OSCILADOR CONTROLADO EN TENSION UNA SEÑAL DE FRECUENCIA PROPORCIONAL A LA SEÑAL DE ERROR. 3<002> INTEGRAR LA SEÑAL DE FRECUENCIA DIVIDIDA EN UN CIRCUITO ACUMULADOR. 4<002> CONVERTIR LA SEÑAL NUMERICA INTEGRADA DEL CIRCUITO ACUMULADOR EN UN CONVERTIDOR DE NUMERICO EN ANALOGICO PARA OBTENER UNA SEÑAL ANALOGICA DE SALIDA. 5<002> DEVOLVER O LLEVAR A REALIMENTACION DICHA SEÑAL ANALOGICA DE SALIDA POR UNA CONEXION DE REALIMENTACION PARA DAR LA SEÑAL DE CIRCUITO COMPARADOR. LA GENERACION DE UNA SEÑAL DE FRECUENCIA INCLUYE LA ACCION DE GENERAR UNA SEÑAL DE CONTROL PARA UNOS CONTADORES DE DOBLE SENTIDO ASOCIADO AL OSCILADOR CONTROLADO EN TENSION.
ES507577A 1979-11-28 1981-11-30 Procedimiento para preparar nuevos derivados de acidos 16-hidroxiprostanoicos 4,5-insaturados. Granted ES507577A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/098,290 US4271314A (en) 1979-11-28 1979-11-28 4,5-Unsaturated prostanoic acid derivatives

Publications (2)

Publication Number Publication Date
ES8300089A1 true ES8300089A1 (es) 1982-10-01
ES507577A0 ES507577A0 (es) 1982-10-01

Family

ID=22268646

Family Applications (2)

Application Number Title Priority Date Filing Date
ES497260A Expired ES8204418A1 (es) 1979-11-28 1980-11-28 Procedimiento para preparar nuevos derivados de acidos 16-hidroxiprostanoicos 4,5-insaturados
ES507577A Granted ES507577A0 (es) 1979-11-28 1981-11-30 Procedimiento para preparar nuevos derivados de acidos 16-hidroxiprostanoicos 4,5-insaturados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES497260A Expired ES8204418A1 (es) 1979-11-28 1980-11-28 Procedimiento para preparar nuevos derivados de acidos 16-hidroxiprostanoicos 4,5-insaturados

Country Status (23)

Country Link
US (1) US4271314A (es)
JP (1) JPS5699457A (es)
AT (1) AT379144B (es)
AU (1) AU539192B2 (es)
BE (1) BE886370A (es)
CA (1) CA1192903A (es)
CH (1) CH646147A5 (es)
DE (1) DE3044794A1 (es)
DK (2) DK504680A (es)
ES (2) ES8204418A1 (es)
FI (1) FI71552C (es)
FR (1) FR2473516A1 (es)
GB (1) GB2065117B (es)
GR (1) GR72283B (es)
IE (1) IE50574B1 (es)
IL (1) IL61575A (es)
IT (1) IT1207155B (es)
NL (1) NL191386C (es)
NO (1) NO155289C (es)
NZ (1) NZ195666A (es)
PT (1) PT72129B (es)
SE (1) SE436873B (es)
ZA (1) ZA807415B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529811A (en) * 1981-03-02 1985-07-16 G. D. Searle & Co. Process for isolating organic compounds and lithium salt complexes useful in said process
US4312994A (en) * 1981-03-25 1982-01-26 G. D. Searle & Co. α Chain dienic prostanoic acid derivatives
US4499296A (en) * 1983-11-14 1985-02-12 G. D. Searle & Co. Omega cycloalkyl prostaglandins
US4754059A (en) * 1984-11-07 1988-06-28 G. D. Searle & Co. Omega cycloalkyl prostaglandins
GB8410396D0 (en) * 1984-04-24 1984-05-31 Glaxo Group Ltd Carbocyclic compounds
US5011958A (en) * 1987-06-08 1991-04-30 G. D. Searle & Co. Process for preparing higher order cuprate complexes
US4785124A (en) * 1987-06-08 1988-11-15 G. D. Searle & Co. Process for preparing higher order cuprate complexes
US4777275A (en) * 1987-06-09 1988-10-11 G. D. Searle & Co. Process of preparing higher order cuprate complexes
US5191109A (en) * 1990-02-02 1993-03-02 Sumitomo Chemical Company, Limited Process for preparing optically active cyclopentenones
WO1999002147A1 (en) 1997-07-09 1999-01-21 Androsolutions, Inc. Improved methods and compositions for treating male erectile dysfunction
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
EP1245562A4 (en) 2000-01-05 2004-12-15 Ono Pharmaceutical Co ALCOHOLS 5-THIA- "OMEGA" - (PHENYL SUBSTITUTED) - PROSTAGLANDIN E, PROCESS FOR THE PREPARATION OF SUCH ALCOHOLS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE ALCOHOLS AS ACTIVE INGREDIENT.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965143A (en) * 1974-03-26 1976-06-22 G. D. Searle & Co. 16-Oxygenated prostanoic acid derivatives
US4028419A (en) * 1976-01-08 1977-06-07 The Upjoin Company 2-Decarboxy-2-hydroxymethyl-cis-4,5-didehydro-PGE, compounds
GB1595119A (en) * 1977-05-31 1981-08-05 Sumitomo Chemical Co 2-hydroxycyclopentaneacetic acid y-lactones and processes for producing them

Also Published As

Publication number Publication date
PT72129A (en) 1980-12-01
GR72283B (es) 1983-10-14
DK613487A (da) 1987-11-23
GB2065117A (en) 1981-06-24
CA1192903A (en) 1985-09-03
AT379144B (de) 1985-11-25
AU6476680A (en) 1981-07-02
NL191386C (nl) 1995-07-03
NL8006473A (nl) 1981-07-01
NO803592L (no) 1981-05-29
JPS6366832B2 (es) 1988-12-22
FR2473516B1 (es) 1983-07-29
SE8008300L (sv) 1981-05-29
ES497260A0 (es) 1982-04-01
ES8204418A1 (es) 1982-04-01
IT8050259A0 (it) 1980-11-27
IE50574B1 (en) 1986-05-14
DK504680A (da) 1981-05-29
CH646147A5 (de) 1984-11-15
SE436873B (sv) 1985-01-28
DK162281B (da) 1991-10-07
AU539192B2 (en) 1984-09-13
ATA579280A (de) 1985-04-15
FI71552C (fi) 1987-01-19
ZA807415B (en) 1982-07-28
DK162281C (da) 1992-03-16
NO155289B (no) 1986-12-01
IT1207155B (it) 1989-05-17
BE886370A (fr) 1981-05-27
JPS5699457A (en) 1981-08-10
DE3044794C2 (es) 1990-02-15
DE3044794A1 (de) 1981-08-27
NZ195666A (en) 1982-12-21
NL191386B (nl) 1995-02-01
IE802471L (en) 1981-05-28
FI803685L (fi) 1981-05-29
IL61575A (en) 1984-05-31
FI71552B (fi) 1986-10-10
NO155289C (no) 1987-03-11
ES507577A0 (es) 1982-10-01
US4271314A (en) 1981-06-02
PT72129B (en) 1981-09-29
DK613487D0 (da) 1987-11-23
GB2065117B (en) 1984-09-05
IL61575A0 (en) 1980-12-31
FR2473516A1 (fr) 1981-07-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303