ES8205395A1 - Procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2- hidroxi-3-alquinilaminopropanos - Google Patents
Procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2- hidroxi-3-alquinilaminopropanosInfo
- Publication number
- ES8205395A1 ES8205395A1 ES500153A ES500153A ES8205395A1 ES 8205395 A1 ES8205395 A1 ES 8205395A1 ES 500153 A ES500153 A ES 500153A ES 500153 A ES500153 A ES 500153A ES 8205395 A1 ES8205395 A1 ES 8205395A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- treatment
- alkinyl
- acylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 1-(ACILAMINO-ARILOXI)-2-HIDROXI-3-ALQUINILAMINOPROPANOS Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I), EN LA QUE R1 ES ESTILO O ISOPROPILO; R3 Y R4 SON HIDROGENO O ALCOHILO C1-3, O FORMAN CONJUNTAMENTE EL GRUPO (CH2)P, VALIENDO "P" DE 4 A 6, Y R2 PUEDE SER VARIOS TIPOS DE RADIALES. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II) CON UNA AMINA DE FORMULA N2NCR3R4C=CH, EN LAS QUE Z ES EL RADIAL DE FORMULA (III) O -CHIH-CH2-HAL, SIENDO HAL UN HALOGENO, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN SISOLVENE INERTE A LA TEMPERATURA DE REFLUJO DEL MEDIO DE REACCION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803009036 DE3009036A1 (de) | 1980-03-08 | 1980-03-08 | Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8205395A1 true ES8205395A1 (es) | 1982-06-01 |
| ES500153A0 ES500153A0 (es) | 1982-06-01 |
Family
ID=6096683
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES500153A Granted ES500153A0 (es) | 1980-03-08 | 1981-03-06 | Procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2- hidroxi-3-alquinilaminopropanos |
| ES509451A Granted ES509451A0 (es) | 1980-03-08 | 1982-02-09 | "procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos". |
| ES509452A Expired ES8302637A1 (es) | 1980-03-08 | 1982-02-09 | "procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos". |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509451A Granted ES509451A0 (es) | 1980-03-08 | 1982-02-09 | "procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos". |
| ES509452A Expired ES8302637A1 (es) | 1980-03-08 | 1982-02-09 | "procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2-hidroxi-3-alquinilaminopropanos". |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4344964A (es) |
| EP (1) | EP0035734B1 (es) |
| JP (1) | JPS56139447A (es) |
| AT (1) | ATE4704T1 (es) |
| AU (1) | AU541550B2 (es) |
| CA (1) | CA1148172A (es) |
| DE (2) | DE3009036A1 (es) |
| DK (1) | DK102681A (es) |
| ES (3) | ES500153A0 (es) |
| FI (1) | FI73665C (es) |
| GB (1) | GB2071097B (es) |
| GR (1) | GR78243B (es) |
| IE (1) | IE52016B1 (es) |
| IL (1) | IL62310A (es) |
| NO (1) | NO150960C (es) |
| NZ (1) | NZ196447A (es) |
| PT (1) | PT72621B (es) |
| ZA (1) | ZA811501B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3009047A1 (de) * | 1980-03-08 | 1981-09-24 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue l-(acylamino-aryloxy-)2-hydroxy-3-alkinylaminopropane und verfahren zu ihrer herstellung |
| DE3133719A1 (de) * | 1981-08-26 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue 1-aryloxy-3-alkinylamino-2-propanole und verfahren zu ihrer herstellung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH546227A (en) * | 1969-08-08 | 1974-02-28 | Boehringer Sohn Ingelheim | 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane |
| CH546224A (en) * | 1969-08-08 | 1974-02-28 | Boehringer Sohn Ingelheim | 1-(2-nitrilophenoxy)-2-hydroxy-3-ethylamino - propane |
| DE2403809C2 (de) * | 1974-01-26 | 1986-02-27 | C.H. Boehringer Sohn, 6507 Ingelheim | 1-Aryloxy-2-hydroxy-3-alkinylaminopropane und Verfahren zu ihrer Herstellung und pharmazeutische Präparate |
| DE2309887C2 (de) * | 1973-02-28 | 1983-11-10 | C.H. Boehringer Sohn, 6507 Ingelheim | 1-Aryloxy-2-hydroxy-3-alkinylaminopropan-Derivate und deren physiologisch verträgliche Säureadditionssalze, pharmazeutische Präparate und Herstellungsverfahren für die Verbindungen |
| AT330150B (de) * | 1973-02-28 | 1976-06-10 | Boehringer Sohn Ingelheim | Verfahren zur herstellung von neuen 1-phenoxy-2-hydroxy -3- propargylaminopropanen und von deren saureadditionssalzen |
-
1980
- 1980-03-08 DE DE19803009036 patent/DE3009036A1/de not_active Withdrawn
-
1981
- 1981-03-03 DE DE8181101499T patent/DE3160912D1/de not_active Expired
- 1981-03-03 AT AT81101499T patent/ATE4704T1/de not_active IP Right Cessation
- 1981-03-03 EP EP81101499A patent/EP0035734B1/de not_active Expired
- 1981-03-05 NO NO810763A patent/NO150960C/no unknown
- 1981-03-05 PT PT72621A patent/PT72621B/pt unknown
- 1981-03-05 JP JP3190481A patent/JPS56139447A/ja active Pending
- 1981-03-06 IE IE487/81A patent/IE52016B1/en unknown
- 1981-03-06 GR GR64338A patent/GR78243B/el unknown
- 1981-03-06 ES ES500153A patent/ES500153A0/es active Granted
- 1981-03-06 AU AU68156/81A patent/AU541550B2/en not_active Ceased
- 1981-03-06 ZA ZA00811501A patent/ZA811501B/xx unknown
- 1981-03-06 DK DK102681A patent/DK102681A/da not_active Application Discontinuation
- 1981-03-06 FI FI810713A patent/FI73665C/fi not_active IP Right Cessation
- 1981-03-06 IL IL62310A patent/IL62310A/xx unknown
- 1981-03-06 CA CA000372484A patent/CA1148172A/en not_active Expired
- 1981-03-06 NZ NZ196447A patent/NZ196447A/en unknown
- 1981-03-06 GB GB8107116A patent/GB2071097B/en not_active Expired
- 1981-03-09 US US06/241,519 patent/US4344964A/en not_active Expired - Fee Related
-
1982
- 1982-02-09 ES ES509451A patent/ES509451A0/es active Granted
- 1982-02-09 ES ES509452A patent/ES8302637A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8302636A1 (es) | 1983-01-16 |
| PT72621B (de) | 1982-11-15 |
| ATE4704T1 (de) | 1983-10-15 |
| FI810713L (fi) | 1981-09-09 |
| NZ196447A (en) | 1984-05-31 |
| DE3009036A1 (de) | 1981-09-24 |
| ZA811501B (en) | 1982-11-24 |
| ES509452A0 (es) | 1983-01-16 |
| ES509451A0 (es) | 1983-01-16 |
| NO150960C (no) | 1985-01-16 |
| FI73665B (fi) | 1987-07-31 |
| GB2071097B (en) | 1983-07-06 |
| NO810763L (no) | 1981-09-09 |
| NO150960B (no) | 1984-10-08 |
| IE52016B1 (en) | 1987-05-27 |
| IE810487L (en) | 1981-09-08 |
| GB2071097A (en) | 1981-09-16 |
| ES8302637A1 (es) | 1983-01-16 |
| EP0035734B1 (de) | 1983-09-21 |
| GR78243B (es) | 1984-09-26 |
| IL62310A (en) | 1984-12-31 |
| ES500153A0 (es) | 1982-06-01 |
| US4344964A (en) | 1982-08-17 |
| CA1148172A (en) | 1983-06-14 |
| DK102681A (da) | 1981-09-09 |
| IL62310A0 (en) | 1981-05-20 |
| EP0035734A1 (de) | 1981-09-16 |
| JPS56139447A (en) | 1981-10-30 |
| FI73665C (fi) | 1987-11-09 |
| DE3160912D1 (en) | 1983-10-27 |
| AU6815681A (en) | 1981-09-17 |
| AU541550B2 (en) | 1985-01-10 |
| PT72621A (de) | 1981-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8205395A1 (es) | Procedimiento para preparar nuevos 1-(acilamino-ariloxi-)2- hidroxi-3-alquinilaminopropanos | |
| ES8205396A1 (es) | Procedimiento para la preparacion de nuevos 1-(acilamino- ariloxi-) 2-hidroxi-3-alquinilaminopropanos | |
| ES8207515A1 (es) | Procedimiento para la preparacion de nuevos 1-ariloxi-3-al- cohilamino-2-propanoles |