ES8205223A1 - Un procedimiento para la preparacion de acidos 6-(1-hidroxietil)-2-2(2-aminoetiltio)-1-carbadetiapen-2-em-3-carboxilicos1,1-di-susitituidos. - Google Patents

Un procedimiento para la preparacion de acidos 6-(1-hidroxietil)-2-2(2-aminoetiltio)-1-carbadetiapen-2-em-3-carboxilicos1,1-di-susitituidos.

Info

Publication number
ES8205223A1
ES8205223A1 ES497382A ES497382A ES8205223A1 ES 8205223 A1 ES8205223 A1 ES 8205223A1 ES 497382 A ES497382 A ES 497382A ES 497382 A ES497382 A ES 497382A ES 8205223 A1 ES8205223 A1 ES 8205223A1
Authority
ES
Spain
Prior art keywords
synthesis
same
preparing
carbadethiapen
aminoethylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497382A
Other languages
English (en)
Other versions
ES497382A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES497382A0 publication Critical patent/ES497382A0/es
Publication of ES8205223A1 publication Critical patent/ES8205223A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
    • C07C17/275—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of hydrocarbons and halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 6-(1-HIDROXIETIL)-2-(2-AMINOETILTIO)-1-CARBADETIAPEN-2-EM-CARBOXILICOS 1,1-DISUSTITUIDOS Y DE SUS SALES Y ESTERES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE OXIDACION DEL COMPUESTO DE FORMULA (II) PARA FORMAR EL COMPUESTO DE FORMULA (III), EN LAS QUE R ES HIDROGENO O UN GRUPO PROTECTOR Y R1 Y R2 SON LOS MISMOS QUE EN LA FORMULA (I), SEGUIDA DE LA REACCION CON R3OOCH2COO-, DONDE R3 ES UN RADICAL ESTER O UN GRUPO PROTECTOR, REACCION CON UNA AZIDA, CICLACION, REACCION DE ACTIVACION DEL COMPUESTO CICLICO OBTENIDO Y REACCION DE ESTE CON UN COMPUESTO DE FORMULA HS-CH2CH2-NHR4, DONDE R4 ES UN GRUPO PROTECTOR.
ES497382A 1979-12-03 1980-12-02 Un procedimiento para la preparacion de acidos 6-(1-hidroxietil)-2-2(2-aminoetiltio)-1-carbadetiapen-2-em-3-carboxilicos1,1-di-susitituidos. Expired ES8205223A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/099,288 US4262010A (en) 1979-12-03 1979-12-03 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids

Publications (2)

Publication Number Publication Date
ES497382A0 ES497382A0 (es) 1982-06-01
ES8205223A1 true ES8205223A1 (es) 1982-06-01

Family

ID=22274224

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497382A Expired ES8205223A1 (es) 1979-12-03 1980-12-02 Un procedimiento para la preparacion de acidos 6-(1-hidroxietil)-2-2(2-aminoetiltio)-1-carbadetiapen-2-em-3-carboxilicos1,1-di-susitituidos.

Country Status (9)

Country Link
US (1) US4262010A (es)
EP (1) EP0030031B1 (es)
JP (1) JPS5699485A (es)
AT (1) ATE22291T1 (es)
DE (1) DE3071764D1 (es)
DK (1) DK513080A (es)
ES (1) ES8205223A1 (es)
GR (1) GR71716B (es)
PT (1) PT72120B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401595A (en) * 1977-03-19 1983-08-30 Beecham Group Limited 4-Allyl azetidinone intermediate for β-lactam antibacterial agents
DE3071008D1 (en) * 1979-04-27 1985-09-26 Merck & Co Inc Process for the preparation of 3-(1-hydroxyethyl)-azetidinones
US4356120A (en) * 1979-07-23 1982-10-26 Merck & Co., Inc. 3-(1-Hydroxyethyl)-4-(but-2-ene)-azetidin-2-one and derivatives
US4386029A (en) * 1979-10-29 1983-05-31 Beecham Group Limited Process for the preparation of antibiotics
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4348264A (en) * 1980-05-14 1982-09-07 Pfizer Inc. Photocatalyzed process for producing carbapenams and carbapen-2-ems
US4341706A (en) * 1980-10-10 1982-07-27 Merck & Co., Inc. Process for the preparation of carbapenem antibiotics
WO1982001705A1 (en) 1980-11-13 1982-05-27 Takeda Chemical Industries Ltd 4-substituted-2-oxoazetidine derivatives and process for their preparation
US4994568A (en) * 1980-12-18 1991-02-19 Merck & Co., Inc. 6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carboxylates
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
ZA821361B (en) * 1981-03-04 1983-01-26 Beecham Group Plc Beta-lactam antibiotics,their preparation and use
AU548727B2 (en) * 1981-03-12 1986-01-02 Gruppo Lepetit S.P.A. Beta-lactam acetic acid derivatives
JPS5946265A (ja) * 1982-08-24 1984-03-15 Sankyo Co Ltd アゼチジノン誘導体の製造法
EP0300657B1 (en) * 1987-07-17 1993-03-31 Merck & Co. Inc. 4-substituted 3-oxobutanoate ester derivatives
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
PT2326648E (pt) * 2008-07-30 2012-10-31 Ranbaxy Lab Ltd Processo de preparação de compostos de carbapenem
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
US4181733A (en) * 1975-11-21 1980-01-01 Merck & Co., Inc. Carboxyl derivatives of thienamycin
BE848545A (fr) * 1975-11-21 1977-05-20 Derives n-methylene substitues de thienamycine,
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
DK446179A (da) * 1978-10-24 1980-05-29 Merck & Co Inc Fremgangsmaade til fremstilling af substituerede 1-carbadethiapen-2-em-3-carboxylsyrer
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids

Also Published As

Publication number Publication date
PT72120B (en) 1982-06-25
ES497382A0 (es) 1982-06-01
EP0030031A2 (en) 1981-06-10
DE3071764D1 (en) 1986-10-23
EP0030031B1 (en) 1986-09-17
JPS5699485A (en) 1981-08-10
PT72120A (en) 1980-12-01
EP0030031A3 (en) 1981-08-26
ATE22291T1 (de) 1986-10-15
DK513080A (da) 1981-06-04
GR71716B (es) 1983-06-21
US4262010A (en) 1981-04-14

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