ES8205223A1 - Un procedimiento para la preparacion de acidos 6-(1-hidroxietil)-2-2(2-aminoetiltio)-1-carbadetiapen-2-em-3-carboxilicos1,1-di-susitituidos. - Google Patents
Un procedimiento para la preparacion de acidos 6-(1-hidroxietil)-2-2(2-aminoetiltio)-1-carbadetiapen-2-em-3-carboxilicos1,1-di-susitituidos.Info
- Publication number
- ES8205223A1 ES8205223A1 ES497382A ES497382A ES8205223A1 ES 8205223 A1 ES8205223 A1 ES 8205223A1 ES 497382 A ES497382 A ES 497382A ES 497382 A ES497382 A ES 497382A ES 8205223 A1 ES8205223 A1 ES 8205223A1
- Authority
- ES
- Spain
- Prior art keywords
- synthesis
- same
- preparing
- carbadethiapen
- aminoethylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 2
- 239000000543 intermediate Substances 0.000 title 2
- 238000003786 synthesis reaction Methods 0.000 title 2
- 230000003115 biocidal effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006257 total synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
- C07C17/275—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of hydrocarbons and halogenated hydrocarbons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 6-(1-HIDROXIETIL)-2-(2-AMINOETILTIO)-1-CARBADETIAPEN-2-EM-CARBOXILICOS 1,1-DISUSTITUIDOS Y DE SUS SALES Y ESTERES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE OXIDACION DEL COMPUESTO DE FORMULA (II) PARA FORMAR EL COMPUESTO DE FORMULA (III), EN LAS QUE R ES HIDROGENO O UN GRUPO PROTECTOR Y R1 Y R2 SON LOS MISMOS QUE EN LA FORMULA (I), SEGUIDA DE LA REACCION CON R3OOCH2COO-, DONDE R3 ES UN RADICAL ESTER O UN GRUPO PROTECTOR, REACCION CON UNA AZIDA, CICLACION, REACCION DE ACTIVACION DEL COMPUESTO CICLICO OBTENIDO Y REACCION DE ESTE CON UN COMPUESTO DE FORMULA HS-CH2CH2-NHR4, DONDE R4 ES UN GRUPO PROTECTOR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/099,288 US4262010A (en) | 1979-12-03 | 1979-12-03 | 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
ES497382A0 ES497382A0 (es) | 1982-06-01 |
ES8205223A1 true ES8205223A1 (es) | 1982-06-01 |
Family
ID=22274224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES497382A Expired ES8205223A1 (es) | 1979-12-03 | 1980-12-02 | Un procedimiento para la preparacion de acidos 6-(1-hidroxietil)-2-2(2-aminoetiltio)-1-carbadetiapen-2-em-3-carboxilicos1,1-di-susitituidos. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4262010A (es) |
EP (1) | EP0030031B1 (es) |
JP (1) | JPS5699485A (es) |
AT (1) | ATE22291T1 (es) |
DE (1) | DE3071764D1 (es) |
DK (1) | DK513080A (es) |
ES (1) | ES8205223A1 (es) |
GR (1) | GR71716B (es) |
PT (1) | PT72120B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4401595A (en) * | 1977-03-19 | 1983-08-30 | Beecham Group Limited | 4-Allyl azetidinone intermediate for β-lactam antibacterial agents |
DE3071008D1 (en) * | 1979-04-27 | 1985-09-26 | Merck & Co Inc | Process for the preparation of 3-(1-hydroxyethyl)-azetidinones |
US4356120A (en) * | 1979-07-23 | 1982-10-26 | Merck & Co., Inc. | 3-(1-Hydroxyethyl)-4-(but-2-ene)-azetidin-2-one and derivatives |
US4386029A (en) * | 1979-10-29 | 1983-05-31 | Beecham Group Limited | Process for the preparation of antibiotics |
US4312871A (en) * | 1979-12-03 | 1982-01-26 | Merck & Co., Inc. | 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids |
US4348264A (en) * | 1980-05-14 | 1982-09-07 | Pfizer Inc. | Photocatalyzed process for producing carbapenams and carbapen-2-ems |
US4341706A (en) * | 1980-10-10 | 1982-07-27 | Merck & Co., Inc. | Process for the preparation of carbapenem antibiotics |
WO1982001705A1 (en) | 1980-11-13 | 1982-05-27 | Takeda Chemical Industries Ltd | 4-substituted-2-oxoazetidine derivatives and process for their preparation |
US4994568A (en) * | 1980-12-18 | 1991-02-19 | Merck & Co., Inc. | 6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carboxylates |
US4350631A (en) * | 1980-12-18 | 1982-09-21 | Merck & Co., Inc. | 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates |
ZA821361B (en) * | 1981-03-04 | 1983-01-26 | Beecham Group Plc | Beta-lactam antibiotics,their preparation and use |
AU548727B2 (en) * | 1981-03-12 | 1986-01-02 | Gruppo Lepetit S.P.A. | Beta-lactam acetic acid derivatives |
JPS5946265A (ja) * | 1982-08-24 | 1984-03-15 | Sankyo Co Ltd | アゼチジノン誘導体の製造法 |
EP0300657B1 (en) * | 1987-07-17 | 1993-03-31 | Merck & Co. Inc. | 4-substituted 3-oxobutanoate ester derivatives |
US5496816A (en) * | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
PT2326648E (pt) * | 2008-07-30 | 2012-10-31 | Ranbaxy Lab Ltd | Processo de preparação de compostos de carbapenem |
WO2011048583A1 (en) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3950357A (en) * | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
US4181733A (en) * | 1975-11-21 | 1980-01-01 | Merck & Co., Inc. | Carboxyl derivatives of thienamycin |
BE848545A (fr) * | 1975-11-21 | 1977-05-20 | Derives n-methylene substitues de thienamycine, | |
US4174316A (en) * | 1978-08-14 | 1979-11-13 | Merck & Co., Inc. | 4-Iodomethylazetidin-2-one |
DK446179A (da) * | 1978-10-24 | 1980-05-29 | Merck & Co Inc | Fremgangsmaade til fremstilling af substituerede 1-carbadethiapen-2-em-3-carboxylsyrer |
US4260627A (en) * | 1978-10-24 | 1981-04-07 | Merck & Co., Inc. | 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids |
-
1979
- 1979-12-03 US US06/099,288 patent/US4262010A/en not_active Expired - Lifetime
-
1980
- 1980-11-27 PT PT72120A patent/PT72120B/pt unknown
- 1980-11-29 GR GR63505A patent/GR71716B/el unknown
- 1980-12-02 ES ES497382A patent/ES8205223A1/es not_active Expired
- 1980-12-02 EP EP80107511A patent/EP0030031B1/en not_active Expired
- 1980-12-02 DE DE8080107511T patent/DE3071764D1/de not_active Expired
- 1980-12-02 AT AT80107511T patent/ATE22291T1/de active
- 1980-12-02 DK DK513080A patent/DK513080A/da not_active Application Discontinuation
- 1980-12-03 JP JP16974580A patent/JPS5699485A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT72120B (en) | 1982-06-25 |
ES497382A0 (es) | 1982-06-01 |
EP0030031A2 (en) | 1981-06-10 |
DE3071764D1 (en) | 1986-10-23 |
EP0030031B1 (en) | 1986-09-17 |
JPS5699485A (en) | 1981-08-10 |
PT72120A (en) | 1980-12-01 |
EP0030031A3 (en) | 1981-08-26 |
ATE22291T1 (de) | 1986-10-15 |
DK513080A (da) | 1981-06-04 |
GR71716B (es) | 1983-06-21 |
US4262010A (en) | 1981-04-14 |
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