JPS5699485A - 66*11hydroxyethyl**22*aminoethylthio**1*11 disubstitutedd11carbadethiapenee22emm33carboxylic acids - Google Patents

66*11hydroxyethyl**22*aminoethylthio**1*11 disubstitutedd11carbadethiapenee22emm33carboxylic acids

Info

Publication number
JPS5699485A
JPS5699485A JP16974580A JP16974580A JPS5699485A JP S5699485 A JPS5699485 A JP S5699485A JP 16974580 A JP16974580 A JP 16974580A JP 16974580 A JP16974580 A JP 16974580A JP S5699485 A JPS5699485 A JP S5699485A
Authority
JP
Japan
Prior art keywords
sup
aminoethylthio
substituted
acids
carbadethiapen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16974580A
Other languages
English (en)
Inventor
Jii Kurisutensen Baaton
Etsuchi Shiii Deibuitsudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS5699485A publication Critical patent/JPS5699485A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
    • C07C17/275—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of hydrocarbons and halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP16974580A 1979-12-03 1980-12-03 66*11hydroxyethyl**22*aminoethylthio**1*11 disubstitutedd11carbadethiapenee22emm33carboxylic acids Pending JPS5699485A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/099,288 US4262010A (en) 1979-12-03 1979-12-03 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids

Publications (1)

Publication Number Publication Date
JPS5699485A true JPS5699485A (en) 1981-08-10

Family

ID=22274224

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16974580A Pending JPS5699485A (en) 1979-12-03 1980-12-03 66*11hydroxyethyl**22*aminoethylthio**1*11 disubstitutedd11carbadethiapenee22emm33carboxylic acids

Country Status (9)

Country Link
US (1) US4262010A (ja)
EP (1) EP0030031B1 (ja)
JP (1) JPS5699485A (ja)
AT (1) ATE22291T1 (ja)
DE (1) DE3071764D1 (ja)
DK (1) DK513080A (ja)
ES (1) ES497382A0 (ja)
GR (1) GR71716B (ja)
PT (1) PT72120B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5946265A (ja) * 1982-08-24 1984-03-15 Sankyo Co Ltd アゼチジノン誘導体の製造法
JPS6434957A (en) * 1987-07-17 1989-02-06 Merck & Co Inc 4-substituted-3-oxobutanoate ester derivative

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401595A (en) * 1977-03-19 1983-08-30 Beecham Group Limited 4-Allyl azetidinone intermediate for β-lactam antibacterial agents
EP0018594B1 (en) * 1979-04-27 1985-08-21 Merck & Co. Inc. Process for the preparation of 3-(1-hydroxyethyl)-azetidinones
US4356120A (en) * 1979-07-23 1982-10-26 Merck & Co., Inc. 3-(1-Hydroxyethyl)-4-(but-2-ene)-azetidin-2-one and derivatives
US4386029A (en) * 1979-10-29 1983-05-31 Beecham Group Limited Process for the preparation of antibiotics
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4348264A (en) * 1980-05-14 1982-09-07 Pfizer Inc. Photocatalyzed process for producing carbapenams and carbapen-2-ems
US4341706A (en) * 1980-10-10 1982-07-27 Merck & Co., Inc. Process for the preparation of carbapenem antibiotics
WO1982001705A1 (en) 1980-11-13 1982-05-27 Takeda Chemical Industries Ltd 4-substituted-2-oxoazetidine derivatives and process for their preparation
US4994568A (en) * 1980-12-18 1991-02-19 Merck & Co., Inc. 6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carboxylates
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
EP0060077A1 (en) * 1981-03-04 1982-09-15 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
AU548727B2 (en) * 1981-03-12 1986-01-02 Gruppo Lepetit S.P.A. Beta-lactam acetic acid derivatives
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
KR20110049823A (ko) * 2008-07-30 2011-05-12 랜박시 래보러터리스 리미티드 카르바페넴 화합물의 제조 방법
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
BE848545A (fr) * 1975-11-21 1977-05-20 Derives n-methylene substitues de thienamycine,
US4181733A (en) * 1975-11-21 1980-01-01 Merck & Co., Inc. Carboxyl derivatives of thienamycin
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
DE2966497D1 (en) * 1978-10-24 1984-01-26 Merck & Co Inc 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5946265A (ja) * 1982-08-24 1984-03-15 Sankyo Co Ltd アゼチジノン誘導体の製造法
JPH0129185B2 (ja) * 1982-08-24 1989-06-08 Sankyo Co
JPS6434957A (en) * 1987-07-17 1989-02-06 Merck & Co Inc 4-substituted-3-oxobutanoate ester derivative

Also Published As

Publication number Publication date
ES8205223A1 (es) 1982-06-01
GR71716B (ja) 1983-06-21
DE3071764D1 (en) 1986-10-23
EP0030031B1 (en) 1986-09-17
PT72120B (en) 1982-06-25
EP0030031A3 (en) 1981-08-26
DK513080A (da) 1981-06-04
ATE22291T1 (de) 1986-10-15
ES497382A0 (es) 1982-06-01
PT72120A (en) 1980-12-01
US4262010A (en) 1981-04-14
EP0030031A2 (en) 1981-06-10

Similar Documents

Publication Publication Date Title
JPS5699485A (en) 66*11hydroxyethyl**22*aminoethylthio**1*11 disubstitutedd11carbadethiapenee22emm33carboxylic acids
AU582601B2 (en) Benzoxazol-and benzothiazolamine derivatives
AU4617093A (en) Substituted cyclohexane derivatives for the treatment of diseases
IL89785A0 (en) Acyl derivatives,their manufacture and pharmaceutical compositions containing them
PT83104B (en) Novel guanidinomethylbenzoic acid derivatives
AU581435B2 (en) ``-carboline-3-carboxylic acid derivatives, method of preparing the same and their use
ES8502118A1 (es) Procedimiento de preparar derivados de penicilina.
JPS5297934A (en) N#-arylsulfonyl-l-argininamides and their salts acceptable as medicine s
PT73948B (en) Process for the preparation of biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof
ES8202327A1 (es) Procedimiento para la preparacion de esteres de acidos aril-propionicos
IE38218B1 (en) Substituted formylazapentadienenitriles and a method for producing them