ES8203850A1 - Un procedimiento para preparar la sal del acido (1-bencil- 1h-indazol-3-il)oxi acetico con lisina - Google Patents
Un procedimiento para preparar la sal del acido (1-bencil- 1h-indazol-3-il)oxi acetico con lisinaInfo
- Publication number
- ES8203850A1 ES8203850A1 ES503509A ES503509A ES8203850A1 ES 8203850 A1 ES8203850 A1 ES 8203850A1 ES 503509 A ES503509 A ES 503509A ES 503509 A ES503509 A ES 503509A ES 8203850 A1 ES8203850 A1 ES 8203850A1
- Authority
- ES
- Spain
- Prior art keywords
- bendazac
- lysine
- indazol
- oxy
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR LA SAL DEL ACIDO (1-BENCIL-1H-INDAZOL-3-IL)-OXI ACETATO Y LISINA POR CALENTAMIENTO EN UN DISOLVENTE, TAL COMO EL ETANOL, ACETONA O MEZCLAS CON AGUA, A PARTIR DE LO CUAL SE CRISTALIZA LA SAL POR ENFRIAMIENTO, TRAS LO CUAL PUEDE SECARSE. TANTO EL BIHIDRATO COMO LAS SALAS ANHIDRIDAS, CON UNA DE LAS DOS FORMAS OPTICAMENTE ACTIVAS DE LISINA, ASI COMO LA SAL DE LISINA RACEMICA, SON EMPLEADOS EN DIRENTES FORMAS FARMACEUTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT23768/80A IT1131779B (it) | 1980-07-29 | 1980-07-29 | Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione |
Publications (2)
Publication Number | Publication Date |
---|---|
ES503509A0 ES503509A0 (es) | 1982-04-01 |
ES8203850A1 true ES8203850A1 (es) | 1982-04-01 |
Family
ID=11209809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES503509A Expired ES8203850A1 (es) | 1980-07-29 | 1981-06-29 | Un procedimiento para preparar la sal del acido (1-bencil- 1h-indazol-3-il)oxi acetico con lisina |
Country Status (17)
Country | Link |
---|---|
US (1) | US4352813A (es) |
JP (1) | JPS5753465A (es) |
AR (1) | AR227677A1 (es) |
AU (1) | AU536243B2 (es) |
BE (1) | BE891914A (es) |
BG (1) | BG60797B2 (es) |
CA (1) | CA1166643A (es) |
CH (1) | CH651556A5 (es) |
DE (1) | DE3202561A1 (es) |
ES (1) | ES8203850A1 (es) |
FR (1) | FR2489318B1 (es) |
GB (1) | GB2081708B (es) |
IT (1) | IT1131779B (es) |
MX (1) | MX156471A (es) |
NL (1) | NL8200222A (es) |
PT (1) | PT73365B (es) |
SE (2) | SE455306B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1189052B (it) * | 1981-11-27 | 1988-01-28 | Acraf | Trattamento della cataratta |
IT1194564B (it) * | 1983-04-18 | 1988-09-22 | Acraf | Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa |
IT1230441B (it) | 1989-02-07 | 1991-10-23 | Acraf | Eteri della serie dell'indazolo |
IT1229674B (it) * | 1989-04-26 | 1991-09-06 | Acraf | Composizione farmaceutica per uso topico oftalmico contenente bendazac o 5-0h bendazac |
US5217983A (en) * | 1992-03-27 | 1993-06-08 | Du Pont Merck Pharmaceutical Company | (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories |
US5272169A (en) * | 1992-03-27 | 1993-12-21 | The Dupont Merck Pharmaceutical Company | (N-benzyl) acetaldehyde bicyclic heterocycles useful as topical antiinflammatories |
IT1293794B1 (it) * | 1997-07-28 | 1999-03-10 | Acraf | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
ITMI20062254A1 (it) * | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
CN103641784B (zh) * | 2013-12-03 | 2018-06-19 | 杭州民生药业有限公司 | 一种苄达赖氨酸合成工艺 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL28032A (en) * | 1966-08-29 | 1971-08-25 | Acraf | Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof |
FR1530097A (fr) | 1966-08-29 | 1968-06-21 | Acraf | Acides indazole-3-yl-oxyalcanoïques et procédé pour leur préparation |
NL6717184A (es) * | 1967-12-16 | 1969-06-18 | Stamicarbon | |
FR2217003A1 (en) * | 1973-02-14 | 1974-09-06 | Inst Investigaciones Terapeuti | Benzopyrilacetic acid deriv prepn - by reacting 1-(p-chlorobenzoyl-2-methyl)-5-methoxy-benzopyrilacetic acid with a base |
DE2940373A1 (de) * | 1979-10-05 | 1981-04-23 | Troponwerke GmbH & Co KG, 5000 Köln | Lysin-(1-(p-chlorbenzoyl)-5-methoxy-2-methyl-3-indol) -acetoxy-acetate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1980
- 1980-07-29 IT IT23768/80A patent/IT1131779B/it active Protection Beyond IP Right Term
-
1981
- 1981-06-02 US US06/269,923 patent/US4352813A/en not_active Expired - Lifetime
- 1981-06-18 GB GB8118767A patent/GB2081708B/en not_active Expired
- 1981-06-23 MX MX187939A patent/MX156471A/es unknown
- 1981-06-29 ES ES503509A patent/ES8203850A1/es not_active Expired
- 1981-07-14 PT PT73365A patent/PT73365B/pt unknown
- 1981-07-15 AR AR286096A patent/AR227677A1/es active
- 1981-07-27 FR FR8114549A patent/FR2489318B1/fr not_active Expired
- 1981-07-28 JP JP56119033A patent/JPS5753465A/ja active Granted
-
1982
- 1982-01-21 NL NL8200222A patent/NL8200222A/nl not_active Application Discontinuation
- 1982-01-26 CA CA000394976A patent/CA1166643A/en not_active Expired
- 1982-01-26 CH CH457/82A patent/CH651556A5/fr not_active IP Right Cessation
- 1982-01-27 AU AU79870/82A patent/AU536243B2/en not_active Ceased
- 1982-01-27 SE SE8200424A patent/SE455306B/sv not_active IP Right Cessation
- 1982-01-27 BE BE0/207152A patent/BE891914A/fr not_active IP Right Cessation
- 1982-01-27 DE DE19823202561 patent/DE3202561A1/de active Granted
-
1983
- 1983-05-04 SE SE8302552A patent/SE8302552L/xx not_active Application Discontinuation
-
1994
- 1994-02-24 BG BG98555A patent/BG60797B2/bg unknown
Also Published As
Publication number | Publication date |
---|---|
FR2489318B1 (fr) | 1986-01-03 |
JPS5753465A (en) | 1982-03-30 |
JPH0322384B2 (es) | 1991-03-26 |
NL8200222A (nl) | 1983-08-16 |
PT73365B (en) | 1982-09-23 |
BG60797B2 (bg) | 1996-03-29 |
PT73365A (en) | 1981-08-01 |
AU7987082A (en) | 1983-08-04 |
CH651556A5 (en) | 1985-09-30 |
SE8302552L (sv) | 1983-07-28 |
AR227677A1 (es) | 1982-11-30 |
ES503509A0 (es) | 1982-04-01 |
MX156471A (es) | 1988-08-26 |
FR2489318A1 (fr) | 1982-03-05 |
DE3202561A1 (de) | 1983-08-04 |
AU536243B2 (en) | 1984-05-03 |
SE455306B (sv) | 1988-07-04 |
SE8200424L (sv) | 1983-07-28 |
SE8302552D0 (sv) | 1983-05-04 |
GB2081708A (en) | 1982-02-24 |
IT8023768A0 (it) | 1980-07-29 |
IT1131779B (it) | 1986-06-25 |
US4352813A (en) | 1982-10-05 |
CA1166643A (en) | 1984-05-01 |
BE891914A (fr) | 1982-05-17 |
GB2081708B (en) | 1984-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20020209 |