ES8203324A1 - Procedimiento para la fabricacion de compuestos antitumora- les a base de platino - Google Patents

Procedimiento para la fabricacion de compuestos antitumora- les a base de platino

Info

Publication number
ES8203324A1
ES8203324A1 ES502411A ES502411A ES8203324A1 ES 8203324 A1 ES8203324 A1 ES 8203324A1 ES 502411 A ES502411 A ES 502411A ES 502411 A ES502411 A ES 502411A ES 8203324 A1 ES8203324 A1 ES 8203324A1
Authority
ES
Spain
Prior art keywords
platinum
complex
isocitrate
preparation
therapeutical application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502411A
Other languages
English (en)
Other versions
ES502411A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES502411A0 publication Critical patent/ES502411A0/es
Publication of ES8203324A1 publication Critical patent/ES8203324A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA FABRICACION DE COMPUESTOS ANTITUMORALES A BASE DE PLATINO. CONSISTE EN EFECTUAR UNA INTERACCION REACTIVA DE UN COMPUESTO DE PLATINO PARCIALMENTE QUELATADO CON EL 1,2-DIAMINOCICLOHEXANO, CON EL ISOCITRATO TRISODICO, PARA FORMAR EL COMPLEJO CIS-ISOCITRATA (1,2-DIAMINOICICLOHEXANO) PLATINO II, PROCEDIENDO A CONTINUACION A AISLAR DEL MEDIO EL COMPLEJO OBTENIDO. INICIALMENTE EL CISDICLORO (1,2-DIAMINOCICLOHEXANO) PLATINO II REACCIONA EN MEDIO ACUOSO CON EL NITRATO DE PLATA PARA DAR EL DINITRATO DEL COMPUESTO DE PLATINO CORRESPONDIENTE, EL CUAL A SU VEZ SE HACE REACCIONAR CON EL ISOCITRATO TRISODICO.
ES502411A 1980-04-29 1981-04-29 Procedimiento para la fabricacion de compuestos antitumora- les a base de platino Expired ES8203324A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8014109 1980-04-29

Publications (2)

Publication Number Publication Date
ES502411A0 ES502411A0 (es) 1982-04-01
ES8203324A1 true ES8203324A1 (es) 1982-04-01

Family

ID=10513074

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502411A Expired ES8203324A1 (es) 1980-04-29 1981-04-29 Procedimiento para la fabricacion de compuestos antitumora- les a base de platino

Country Status (32)

Country Link
US (1) US4452812A (es)
EP (1) EP0039272B1 (es)
JP (1) JPS595599B2 (es)
AR (1) AR226354A1 (es)
AT (1) AT372072B (es)
AU (1) AU6978681A (es)
BE (1) BE888367A (es)
CA (1) CA1171425A (es)
DD (1) DD158777A5 (es)
DE (1) DE3163162D1 (es)
DK (1) DK188481A (es)
ES (1) ES8203324A1 (es)
FI (1) FI811314L (es)
FR (1) FR2481289B1 (es)
GB (1) GB2077720B (es)
GR (1) GR75598B (es)
IE (1) IE51197B1 (es)
IL (1) IL62615A0 (es)
IT (1) IT1146749B (es)
JO (1) JO1176B1 (es)
LU (1) LU83325A1 (es)
MA (1) MA19131A1 (es)
MC (1) MC1391A1 (es)
NO (1) NO811449L (es)
NZ (1) NZ196803A (es)
OA (1) OA06797A (es)
PL (1) PL128539B1 (es)
PT (1) PT72941B (es)
RO (1) RO82032B (es)
YU (1) YU102581A (es)
ZA (1) ZA812474B (es)
ZW (1) ZW8681A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59112995A (ja) * 1982-12-21 1984-06-29 Shionogi & Co Ltd 新規グリコ−ル酸白金錯体
AU558747B2 (en) * 1983-05-10 1987-02-05 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
US4720504A (en) * 1983-05-10 1988-01-19 Andrulis Research Corporation Use of bis-platinum complexes as antitumor agents
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
GR82129B (es) * 1983-06-20 1984-12-13 Research Corp
US4758588A (en) * 1983-06-20 1988-07-19 Research Corporation Technologies Diaminocyclohexane platinum complexes
US4562275A (en) * 1984-03-23 1985-12-31 Bristol-Myers Co. Antitumor platinum complexes
EP0169645A1 (en) * 1984-06-27 1986-01-29 Johnson Matthey Public Limited Company Platinum co-ordination compounds
ATE49214T1 (de) * 1984-12-17 1990-01-15 American Cyanamid Co Platinkomplexe von aliphatischen tricarbonsaeuren.
US5011959A (en) * 1986-11-17 1991-04-30 The Board Of Regents, The University Of Texas System 1,2-diaminocyclohexane-platinum complexes with antitumor activity
CA1283904C (en) * 1987-03-06 1991-05-07 Mitsuaki Maeda Liposoluble platinum (ii) complex and preparation thereof
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
JPH0776229B2 (ja) * 1989-12-12 1995-08-16 東レ株式会社 新規白金（２）錯体および悪性腫瘍治療剤
JP3154399B2 (ja) * 1996-07-04 2001-04-09 デビオファーム エス．アー． 白金化合物の製造方法
US6689928B2 (en) 2000-04-04 2004-02-10 Exxonmobil Research And Engineering Company Transition metal complexes and oligomers therefrom
DE10206648A1 (de) * 2002-02-15 2003-09-11 November Ag Molekulare Medizin Wirkstoff zur Herstellung eines Stoffs zur Beeinflussung der Koagulationsbereitschaft des Bluts
PT1695991E (pt) * 2003-12-10 2010-03-02 Toudai Tlo Ltd Complexo de coordenação de diaminociclohexano platina (ii) com copolímero de bloco contendo segmento poli(ácido carboxílico) e agente antitumoral compreendendo o mesmo
DE102004005906B3 (de) * 2004-02-05 2005-09-29 W.C. Heraeus Gmbh Verfahren zur Herstellung von 1,2-Diaminocylohexan-Platin(II)-Komplexen
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2006098496A1 (ja) * 2005-03-18 2006-09-21 The University Of Tokyo ジアミノシクロヘキサン白金(ii)とブロック共重合体との配位化合物及びそれを含有する抗がん剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH605550A5 (es) * 1972-06-08 1978-09-29 Research Corp
US4115418A (en) * 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
US4206226A (en) * 1977-08-29 1980-06-03 The United States Of America As Represented By The Department Of Health, Education And Welfare Use of 4-carboxy-phthalato-(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof in alleviating L1210 murine leukemia
JPS5829957B2 (ja) * 1977-09-12 1983-06-25 喜徳 喜谷 新規な白金錯体
US4203912A (en) * 1977-10-19 1980-05-20 Johnson, Matthey & Co., Limited Compositions containing platinum
US4225529A (en) * 1977-10-19 1980-09-30 Johnson, Matthey & Co., Limited Compositions containing platinum
SE7903359L (sv) * 1978-04-20 1979-10-21 Johnson Matthey Co Ltd Kompositioner innehallande platina
US4284579A (en) * 1979-07-17 1981-08-18 The United States Of America As Represented By The Of The Department Of Health & Human Services (N-Phosphonacetyl-L-aspartato)(1,2-diaminocyclchexane)platinum(II) or alkali metal salt

Also Published As

Publication number Publication date
JO1176B1 (en) 1983-11-30
PT72941A (fr) 1981-05-01
MC1391A1 (fr) 1982-04-27
FR2481289B1 (fr) 1985-06-14
DD158777A5 (de) 1983-02-02
IT1146749B (it) 1986-11-19
ES502411A0 (es) 1982-04-01
ZW8681A1 (en) 1981-07-08
US4452812A (en) 1984-06-05
EP0039272A3 (en) 1982-05-05
GB2077720B (en) 1983-09-07
LU83325A1 (fr) 1981-07-24
NZ196803A (en) 1983-12-16
PL128539B1 (en) 1984-02-29
IL62615A0 (en) 1981-06-29
AT372072B (de) 1983-08-25
PL230896A1 (es) 1982-01-04
DK188481A (da) 1981-10-30
NO811449L (no) 1981-10-30
IE51197B1 (en) 1986-10-29
RO82032A (ro) 1984-01-14
OA06797A (fr) 1982-12-31
IE810925L (en) 1981-10-29
ATA191981A (de) 1983-01-15
DE3163162D1 (en) 1984-10-04
PT72941B (fr) 1982-03-30
ZA812474B (en) 1982-05-26
GR75598B (es) 1984-08-01
IT8167555A0 (it) 1981-04-23
AR226354A1 (es) 1982-06-30
JPS595599B2 (ja) 1984-02-06
MA19131A1 (fr) 1981-12-31
CA1171425A (en) 1984-07-24
RO82032B (ro) 1984-01-30
YU102581A (en) 1983-09-30
EP0039272B1 (fr) 1984-04-18
BE888367A (fr) 1981-07-31
EP0039272A2 (fr) 1981-11-04
AU6978681A (en) 1981-11-05
GB2077720A (en) 1981-12-23
FI811314L (fi) 1981-10-30
FR2481289A1 (fr) 1981-10-30
JPS572296A (en) 1982-01-07

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