ES8201419A1 - Un metodo para preparar una solucion acuosa de nitrogliceri-na - Google Patents

Un metodo para preparar una solucion acuosa de nitrogliceri-na

Info

Publication number
ES8201419A1
ES8201419A1 ES496747A ES496747A ES8201419A1 ES 8201419 A1 ES8201419 A1 ES 8201419A1 ES 496747 A ES496747 A ES 496747A ES 496747 A ES496747 A ES 496747A ES 8201419 A1 ES8201419 A1 ES 8201419A1
Authority
ES
Spain
Prior art keywords
nitroglycerin
aqueous solution
xylitol
mannitol
sorbitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496747A
Other languages
English (en)
Other versions
ES496747A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Publication of ES8201419A1 publication Critical patent/ES8201419A1/es
Publication of ES496747A0 publication Critical patent/ES496747A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO PARA PREPARAR UNA SOLUCION ACUOSA DE NITROGLICERINA. COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, SE DISUELVE NITROGLICERINA EN UN DISOLVENTE ORGANICO MUY VOLATIL SELECCIONADO ENTRE METANOL ETANOL Y ACETONA; SEGUNDA, MEZCLAR UNIFORMEMENTE LA SOLUCION RESULTANTE CON POLVO DE AL MENOS UNA SUSTANCIA SELECCIONADA ENTRE MANITA, SORBITA Y XILITA; TERCERA, VOLATILIZAR DICHO DISOLVENTE ORGANICO DE LA MEZCLA FORMADA EN LA SEGUNDA ETAPA, PARA OBTENER UNA MASA EN POLVO QUE CONTIENE NITROGLICERINA ABSORBIDA; Y POR ULTIMO, DISOLVER EN AGUA DICHA MASA EN POLVO. DE USO EN MEDICINA PARA CURAR ENFERMEDADES CIRCULATORIAS, TALES COMO ANGINA DE PECHO, ASMA CARDIACO Y ANEMIA CEREBRAL.
ES496747A 1979-11-13 1980-11-12 Un metodo para preparar una solucion acuosa de nitrogliceri-na Granted ES496747A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54146011A JPS599539B2 (ja) 1979-11-13 1979-11-13 ニトログリセリン水溶液及びその製造法

Publications (2)

Publication Number Publication Date
ES8201419A1 true ES8201419A1 (es) 1981-11-16
ES496747A0 ES496747A0 (es) 1981-11-16

Family

ID=15398067

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496747A Granted ES496747A0 (es) 1979-11-13 1980-11-12 Un metodo para preparar una solucion acuosa de nitrogliceri-na

Country Status (9)

Country Link
US (1) US4323577A (es)
JP (1) JPS599539B2 (es)
CA (1) CA1163199A (es)
DE (1) DE3042332A1 (es)
DK (1) DK161186C (es)
ES (1) ES496747A0 (es)
FR (1) FR2469178A1 (es)
GB (1) GB2062467B (es)
IT (1) IT1147022B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059264A1 (es) * 1992-11-05 1994-11-01 Berrazueta Fernandez Jose Ramo Utilizacion de los nitrovasodilatadores en la preparacion de medicamentos antiinflamatorios y analgesicos de uso topico.

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1163561A (en) * 1979-11-06 1984-03-13 Cyril Boroda Preparation containing nitroglycerine and optionally other medicaments and preparation thereof
DE3109783A1 (de) * 1981-03-13 1982-10-07 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Mit wasser zu einer etwa isotonischen nitroglycerinloesung aufloesbare zubereitung und derartige nitroglycerinloesung
DE3237284A1 (de) * 1982-10-08 1984-04-12 G. Pohl-Boskamp GmbH & Co Chemisch-pharmazeutische Fabrik, 2214 Hohenlockstedt Loesungsvermittlerfreie, waessrige nitroglycerinloesung
JPH0653658B2 (ja) * 1984-12-17 1994-07-20 中外製薬株式会社 安定な錠剤の製造法
JPH0665647B2 (ja) * 1985-06-12 1994-08-24 株式会社三和化学研究所 移植皮膚処置剤
KR950010150B1 (ko) * 1986-01-14 1995-09-11 쥬우가이세이야꾸 가부시끼가이샤 니코란딜 함유 주사제의 안정화 방법
KR940000232B1 (ko) * 1986-01-17 1994-01-12 쥬우가이세이야꾸 가부시끼가이샤 니코란딜 제제의 안정화 방법
FI871447A (fi) * 1986-04-07 1987-10-08 Bristol Myers Co Stabila injicerbara antivomitiva kompositioner.
US4882356A (en) * 1987-03-10 1989-11-21 Nassar Munir N Stable injectable antiemetic compositions
US4816568A (en) * 1986-05-16 1989-03-28 International Minerals & Chemical Corp. Stabilization of growth hormones
US4879308A (en) * 1987-08-11 1989-11-07 Lyphomed, Inc. Aqueous nitroglycerin injection and manufacturing process
US5001151A (en) * 1987-08-11 1991-03-19 Fujisawa Usa, Inc. Aqueous nitroglycerin injection and manufacturing process
JPH0645538B2 (ja) * 1987-09-30 1994-06-15 日本化薬株式会社 ニトログリセリンスプレー剤
DE4026072A1 (de) * 1990-08-17 1992-02-20 Sanol Arznei Schwarz Gmbh Nitroglycerinhaltiger, hydrophiler, waessriger pumpspray
EP0835098B1 (de) 1995-06-27 2002-09-04 Boehringer Ingelheim Pharma KG Neue stabile arzneimittelzubereitung zur erzeugung treibgasfreier aerosole
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
DE202008007318U1 (de) * 2008-03-14 2008-07-31 G. Pohl-Boskamp Gmbh & Co. Kg Langzeitstabile pharmazeutische Zubereitung mit dem Wirkstoff Glyceroltrinitrat
CA2806636C (en) 2010-08-03 2018-01-23 G. Pohl-Boskamp Gmbh & Co. Kg Use of glyceryl trinitrate for treating traumatic edema
EP2678006B1 (en) 2011-02-25 2015-12-30 G. Pohl-Boskamp GmbH & Co. KG Packaging of solid pharmaceutical preparations containing the active substance glyceryl trinitrate
US9248099B2 (en) 2012-05-31 2016-02-02 Desmoid Aktiengesellschaft Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
PL2668947T3 (pl) 2012-05-31 2017-06-30 G. Pohl-Boskamp Gmbh & Co. Kg Indukcja arteriogenezy donorem NO, takim jak nitrogliceryna
EP2878310B1 (en) 2013-11-29 2017-01-11 G. Pohl-Boskamp GmbH & Co. KG Sprayable aqueous composition comprising glyceryl trinitrate
CN116251057B (zh) * 2022-12-29 2024-06-07 平光制药股份有限公司 一种硝酸异山梨酯注射液及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632504A (es) * 1962-05-24
CH513760A (it) 1970-10-14 1971-10-15 I B Anstalt Impianto automatico di caricamento di fardelli di formato uniforme su veicoli
DE2301664C3 (de) 1973-01-13 1979-07-12 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Oral verabreichbares, Nitroglycerin enthaltendes Arzneimittel
JPS5138412A (en) 1974-09-24 1976-03-31 Nippon Kayaku Kk Kokoseizai no seiho

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059264A1 (es) * 1992-11-05 1994-11-01 Berrazueta Fernandez Jose Ramo Utilizacion de los nitrovasodilatadores en la preparacion de medicamentos antiinflamatorios y analgesicos de uso topico.

Also Published As

Publication number Publication date
FR2469178A1 (fr) 1981-05-22
CA1163199A (en) 1984-03-06
IT1147022B (it) 1986-11-19
US4323577A (en) 1982-04-06
JPS5671046A (en) 1981-06-13
DK161186C (da) 1991-11-25
DK482180A (da) 1981-05-14
JPS599539B2 (ja) 1984-03-03
FR2469178B1 (es) 1983-12-23
DE3042332C2 (es) 1988-08-25
DK161186B (da) 1991-06-10
GB2062467A (en) 1981-05-28
GB2062467B (en) 1983-07-20
DE3042332A1 (de) 1981-05-21
IT8050122A0 (it) 1980-11-11
ES496747A0 (es) 1981-11-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303