ES8200900A1 - Un procedimiento para la preparacion de un derivado de gua- nidina de una polien-macrolida o uno de sus esteres - Google Patents

Un procedimiento para la preparacion de un derivado de gua- nidina de una polien-macrolida o uno de sus esteres

Info

Publication number
ES8200900A1
ES8200900A1 ES498074A ES498074A ES8200900A1 ES 8200900 A1 ES8200900 A1 ES 8200900A1 ES 498074 A ES498074 A ES 498074A ES 498074 A ES498074 A ES 498074A ES 8200900 A1 ES8200900 A1 ES 8200900A1
Authority
ES
Spain
Prior art keywords
esters
processes
preparation
pharmaceutical compositions
water soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498074A
Other languages
English (en)
Other versions
ES498074A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Dumex AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex AS filed Critical Dumex AS
Publication of ES498074A0 publication Critical patent/ES498074A0/es
Publication of ES8200900A1 publication Critical patent/ES8200900A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

PROCEDIMIENTO DE PREPARACION DE UNN DERIVADO DE GUANIDINA DE UNA POLIENMACROLIDA O UNO DE SUS ESTERES. SE OBTIENE POR LA REACCION A TEMPERATURA DE 0 A 10C EN PRESENCIA DE N-METILPIRROLIDONA, DE UNA MACROLIDA POLIENICA CONTENIENDO AL MENOS UN GRUPO AMINO LIBRE Y OTRO CARBOXILO LIBRE, CON UNA CARBODIIMIDA DE FORMULA (I), EN QUE R1, Y R2 SON UN GRUPO ALCOHILO SUSTITUIDO O NO, ARALCOHILO, ARILO OARAOIALCOHILO. PARA OBTENER EL COMPUESTO ENFORMA DE ESTER, LA REACCION SE EFECTUA EN UN COMPUESTO DE FORMULA (II), EN QUE R ES UN GRUPO ALCOHILO, CICLOALCOHILO, ARALCOHILO O ARILO, Y EN PRESENCIA DE UN ACIDO QUE NO SEA ESTERIFICADO. SE USAN COMO AGENTES ANTIMICOTICOS.
ES498074A 1979-12-24 1980-12-23 Un procedimiento para la preparacion de un derivado de gua- nidina de una polien-macrolida o uno de sus esteres Expired ES8200900A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7944360 1979-12-24

Publications (2)

Publication Number Publication Date
ES498074A0 ES498074A0 (es) 1981-11-16
ES8200900A1 true ES8200900A1 (es) 1981-11-16

Family

ID=10510052

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498074A Expired ES8200900A1 (es) 1979-12-24 1980-12-23 Un procedimiento para la preparacion de un derivado de gua- nidina de una polien-macrolida o uno de sus esteres

Country Status (11)

Country Link
US (1) US4396610A (es)
EP (1) EP0031722B1 (es)
JP (1) JPS56127394A (es)
AT (1) ATE6864T1 (es)
CA (1) CA1159053A (es)
DE (1) DE3067300D1 (es)
DK (1) DK538680A (es)
ES (1) ES8200900A1 (es)
FI (1) FI804004L (es)
NO (1) NO149390C (es)
ZA (1) ZA807892B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826822A (en) * 1986-04-22 1989-05-02 Ecolab Inc. Liquid suspensions of polyene antibiotics and use thereof for slime control in industrial waters
HU205366B (en) * 1988-11-18 1992-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing water-soluble primycin complexes and pharmaceutical compositions comprising such active ingredient
US5607691A (en) * 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US8217013B2 (en) * 2007-07-30 2012-07-10 Shanghai Institute Of Pharmaceutical Industry Polyene diester antibiotics
EP2852601A1 (en) 2012-03-09 2015-04-01 Blirt S.A. Semisynthetic derivatives of nystatin a1
WO2013186384A1 (en) 2012-06-15 2013-12-19 Blirt S.A. N-substituted second generation derivatives of antifungal antibiotic amphotericin b and methods of their preparation and application
BR112016028890A8 (pt) 2014-06-12 2021-03-23 Shionogi & Co composto derivado de macrolídeo de polieno, composição farmacêutica compreendendo o referido composto e processo para a preparação do mesmo

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957754A (en) * 1970-12-21 1976-05-18 E. R. Squibb & Sons, Inc. Complexes of antifungal polyene antibiotics
US3945993A (en) * 1971-06-07 1976-03-23 Rutgers Research And Educational Foundation Derivatives of polyene macrolide antibiotics
FI60877C (fi) * 1971-08-13 1982-04-13 Politechnika Gdanska Foerfarande foer framstaellning av terapeutiskt aktiva i vatten laett dispergerbara polyenmakrolidantibiot-n-glykosylderivat
US4195172A (en) * 1976-04-22 1980-03-25 Politechnika Gdanska Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their preparation
US4272525A (en) * 1978-10-23 1981-06-09 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
PL124710B1 (en) * 1979-07-18 1983-02-28 Politechnika Gdanska Process for preparing esters of antibiotics from polyene macrolids group and their n-substituted derivatives

Also Published As

Publication number Publication date
ES498074A0 (es) 1981-11-16
US4396610A (en) 1983-08-02
ZA807892B (en) 1981-12-30
NO803922L (no) 1981-06-25
EP0031722A1 (en) 1981-07-08
DE3067300D1 (en) 1984-05-03
FI804004L (fi) 1981-06-25
DK538680A (da) 1981-06-25
CA1159053A (en) 1983-12-20
JPS56127394A (en) 1981-10-06
NO149390B (no) 1984-01-02
NO149390C (no) 1984-04-11
EP0031722B1 (en) 1984-03-28
ATE6864T1 (de) 1984-04-15

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