JPS5470291A - Antibiotics; tyrosine derivatives - Google Patents
Antibiotics; tyrosine derivativesInfo
- Publication number
- JPS5470291A JPS5470291A JP13496177A JP13496177A JPS5470291A JP S5470291 A JPS5470291 A JP S5470291A JP 13496177 A JP13496177 A JP 13496177A JP 13496177 A JP13496177 A JP 13496177A JP S5470291 A JPS5470291 A JP S5470291A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- antibiotics
- lower alkyl
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
NEW MATERIAL:Compounds of formula I (R1 is H, acetyl; R2 is H, hydroxyl, lower lower alkanoylxy R3 is lower alkyl, aryl, arylsulfonyl or lower alkyl substituted with a specific heterocycle).
EXAMPLE: 4"-Cyclohexylthioacetyltyrosine.
USE: Antibiotics: being effctive against gram-positive bacteria, Mycoplasma and a variery of bacteria resisting medicines and characterized by the selective acylation of the hydroxyl group in 4"-position.
PREPARATION: The compound of formula IV resulting from the reaction between a compound of formula II (R4 is lower alkanoyl; R5 is halogenated lower alkanoyl) and another compound of formula III (X is halogen, pivaloyloxy) in the presence of a basic reagent is hydrolyzed to eliminate acyl groups in 2',4" positions, thereby giving the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13496177A JPS5470291A (en) | 1977-11-09 | 1977-11-09 | Antibiotics; tyrosine derivatives |
US05/954,055 US4205163A (en) | 1977-11-08 | 1978-10-23 | Tylosin derivatives |
EP78101304A EP0001841B1 (en) | 1977-11-08 | 1978-11-03 | Tylosin derivatives |
DE7878101304T DE2862111D1 (en) | 1977-11-08 | 1978-11-03 | Tylosin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13496177A JPS5470291A (en) | 1977-11-09 | 1977-11-09 | Antibiotics; tyrosine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5470291A true JPS5470291A (en) | 1979-06-05 |
JPS6121238B2 JPS6121238B2 (en) | 1986-05-26 |
Family
ID=15140619
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13496177A Granted JPS5470291A (en) | 1977-11-08 | 1977-11-09 | Antibiotics; tyrosine derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5470291A (en) |
-
1977
- 1977-11-09 JP JP13496177A patent/JPS5470291A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6121238B2 (en) | 1986-05-26 |
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