JPS5470291A - Antibiotics; tyrosine derivatives - Google Patents

Antibiotics; tyrosine derivatives

Info

Publication number
JPS5470291A
JPS5470291A JP13496177A JP13496177A JPS5470291A JP S5470291 A JPS5470291 A JP S5470291A JP 13496177 A JP13496177 A JP 13496177A JP 13496177 A JP13496177 A JP 13496177A JP S5470291 A JPS5470291 A JP S5470291A
Authority
JP
Japan
Prior art keywords
formula
compound
antibiotics
lower alkyl
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13496177A
Other languages
Japanese (ja)
Other versions
JPS6121238B2 (en
Inventor
Toshiaki Mori
Rokuro Okamoto
Taiji Inui
Tomio Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Inc
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc, Sanraku Ocean Co Ltd filed Critical Sanraku Inc
Priority to JP13496177A priority Critical patent/JPS5470291A/en
Priority to US05/954,055 priority patent/US4205163A/en
Priority to EP78101304A priority patent/EP0001841B1/en
Priority to DE7878101304T priority patent/DE2862111D1/en
Publication of JPS5470291A publication Critical patent/JPS5470291A/en
Publication of JPS6121238B2 publication Critical patent/JPS6121238B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (R1 is H, acetyl; R2 is H, hydroxyl, lower lower alkanoylxy R3 is lower alkyl, aryl, arylsulfonyl or lower alkyl substituted with a specific heterocycle).
EXAMPLE: 4"-Cyclohexylthioacetyltyrosine.
USE: Antibiotics: being effctive against gram-positive bacteria, Mycoplasma and a variery of bacteria resisting medicines and characterized by the selective acylation of the hydroxyl group in 4"-position.
PREPARATION: The compound of formula IV resulting from the reaction between a compound of formula II (R4 is lower alkanoyl; R5 is halogenated lower alkanoyl) and another compound of formula III (X is halogen, pivaloyloxy) in the presence of a basic reagent is hydrolyzed to eliminate acyl groups in 2',4" positions, thereby giving the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP13496177A 1977-11-08 1977-11-09 Antibiotics; tyrosine derivatives Granted JPS5470291A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP13496177A JPS5470291A (en) 1977-11-09 1977-11-09 Antibiotics; tyrosine derivatives
US05/954,055 US4205163A (en) 1977-11-08 1978-10-23 Tylosin derivatives
EP78101304A EP0001841B1 (en) 1977-11-08 1978-11-03 Tylosin derivatives
DE7878101304T DE2862111D1 (en) 1977-11-08 1978-11-03 Tylosin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13496177A JPS5470291A (en) 1977-11-09 1977-11-09 Antibiotics; tyrosine derivatives

Publications (2)

Publication Number Publication Date
JPS5470291A true JPS5470291A (en) 1979-06-05
JPS6121238B2 JPS6121238B2 (en) 1986-05-26

Family

ID=15140619

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13496177A Granted JPS5470291A (en) 1977-11-08 1977-11-09 Antibiotics; tyrosine derivatives

Country Status (1)

Country Link
JP (1) JPS5470291A (en)

Also Published As

Publication number Publication date
JPS6121238B2 (en) 1986-05-26

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