JPS5466692A - Sulfonyl derivative of antibiotic substance tylosine - Google Patents

Sulfonyl derivative of antibiotic substance tylosine

Info

Publication number
JPS5466692A
JPS5466692A JP13442877A JP13442877A JPS5466692A JP S5466692 A JPS5466692 A JP S5466692A JP 13442877 A JP13442877 A JP 13442877A JP 13442877 A JP13442877 A JP 13442877A JP S5466692 A JPS5466692 A JP S5466692A
Authority
JP
Japan
Prior art keywords
tylosine
alkanoyl
compound
halo
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13442877A
Other languages
Japanese (ja)
Other versions
JPS6121237B2 (en
Inventor
Toshiaki Mori
Rokuro Okamoto
Taiji Inui
Tomio Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Inc
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc, Sanraku Ocean Co Ltd filed Critical Sanraku Inc
Priority to JP13442877A priority Critical patent/JPS5466692A/en
Priority to US05/954,055 priority patent/US4205163A/en
Priority to EP78101304A priority patent/EP0001841B1/en
Priority to DE7878101304T priority patent/DE2862111D1/en
Publication of JPS5466692A publication Critical patent/JPS5466692A/en
Publication of JPS6121237B2 publication Critical patent/JPS6121237B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Tylosine derivative of formula I (R1 is H, acetyl; R2 is aryl, aralkyl, arylthio-lower-alkyl), or its acid addition salt.
EXAMPLE: 4"-(4-Nitrobenzenesulfonyl)tylosine.
USE: Antibacterial agent effective to gram-positive bacteria, micoplasma, and their resistant variant. Easily absorbed through digestive tract by oral administration. Characterized by the selective sulfonylation of OH at the 4" position.
PROCESS: A compound of formula II (R3 is lower alkanoyl, halo-lower-alkanoyl; R4 is halo-lower-alkanoyl, lower alkoxycarbonyl, aryloxy-alkanoyl) is made to react with a compound III in the presence of a basic reagent to afford a compound IV which is deacylated by hydrolysis, alcoholysis, etc. to obtain the compound IX.
COPYRIGHT: (C)1979,JPO&Japio
JP13442877A 1977-11-08 1977-11-08 Sulfonyl derivative of antibiotic substance tylosine Granted JPS5466692A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP13442877A JPS5466692A (en) 1977-11-08 1977-11-08 Sulfonyl derivative of antibiotic substance tylosine
US05/954,055 US4205163A (en) 1977-11-08 1978-10-23 Tylosin derivatives
EP78101304A EP0001841B1 (en) 1977-11-08 1978-11-03 Tylosin derivatives
DE7878101304T DE2862111D1 (en) 1977-11-08 1978-11-03 Tylosin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13442877A JPS5466692A (en) 1977-11-08 1977-11-08 Sulfonyl derivative of antibiotic substance tylosine

Publications (2)

Publication Number Publication Date
JPS5466692A true JPS5466692A (en) 1979-05-29
JPS6121237B2 JPS6121237B2 (en) 1986-05-26

Family

ID=15128141

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13442877A Granted JPS5466692A (en) 1977-11-08 1977-11-08 Sulfonyl derivative of antibiotic substance tylosine

Country Status (1)

Country Link
JP (1) JPS5466692A (en)

Also Published As

Publication number Publication date
JPS6121237B2 (en) 1986-05-26

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