ES8105012A1 - Procedimiento para la preparacion de derivados 17-beta de 4-diazo-5- alfa-androstan-3-onas - Google Patents
Procedimiento para la preparacion de derivados 17-beta de 4-diazo-5- alfa-androstan-3-onasInfo
- Publication number
- ES8105012A1 ES8105012A1 ES491010A ES491010A ES8105012A1 ES 8105012 A1 ES8105012 A1 ES 8105012A1 ES 491010 A ES491010 A ES 491010A ES 491010 A ES491010 A ES 491010A ES 8105012 A1 ES8105012 A1 ES 8105012A1
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- alpha
- testosterone
- diazo
- reductase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS 17-BETA DE 4-DIAZO-5-ALFA-ANDROSTAN-3-ONAS DE FORMULA (I), EN DONDE R PUEDE SER DISTINTOS TIPOS DE RADICALES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON CLORURO DE TRIMETILSILILO Y POSTERIOR TRATAMIENTO CON UN AGENTE HIDROGENADOR, CON LO CUAL SE OBTIENE EL COMPUESTO (III); ESTE DERIVADO REACCIONA CON UN ALQUIL LITIO Y CON CLORURO DE BENZOILO O UN CLORURO DE ACIDO ALQUILO INFERIOR, Y EL PRODUCTO OBTENIDO REACCIONA CON HIDRURO DE SODIO O UNA TRIALQUILAMINA INFERIOR Y P-TOLUENSULFONIL AZIURO; DE ESTA FORMA SE PREPARA EL DERIVADO DESEADO. ESTOS COMPUESTOS SE UTILIZAN PARA EL TRATAMIENTO DE ACNE Y DE PIEL GRASA. *FORMULA*
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3535779A | 1979-05-02 | 1979-05-02 | |
US6974179A | 1979-08-27 | 1979-08-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES491010A0 ES491010A0 (es) | 1981-05-16 |
ES8105012A1 true ES8105012A1 (es) | 1981-05-16 |
Family
ID=26712031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES491010A Expired ES8105012A1 (es) | 1979-05-02 | 1980-04-29 | Procedimiento para la preparacion de derivados 17-beta de 4-diazo-5- alfa-androstan-3-onas |
Country Status (16)
Country | Link |
---|---|
AT (1) | AT390794B (es) |
AU (1) | AU532558B2 (es) |
CA (1) | CA1154008A (es) |
CH (1) | CH643863A5 (es) |
DE (1) | DE3017015A1 (es) |
DK (1) | DK166501B1 (es) |
ES (1) | ES8105012A1 (es) |
FR (1) | FR2455610A1 (es) |
GB (1) | GB2048888B (es) |
IE (1) | IE49704B1 (es) |
IL (1) | IL59934A (es) |
IT (1) | IT1188932B (es) |
NL (1) | NL191387C (es) |
NO (1) | NO154884C (es) |
NZ (1) | NZ193527A (es) |
SE (1) | SE448097B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8503940D0 (en) * | 1985-02-15 | 1985-03-20 | Erba Farmitalia | 4-substituted androstendione derivatives |
NZ239141A (en) * | 1990-08-01 | 1994-04-27 | Merrell Dow Pharma | 4-amino-delta-4,6-steroids; preparatory processes and pharmaceutical compositions |
NZ239142A (en) * | 1990-08-01 | 1994-05-26 | Merrell Dow Pharma | 4-amino-delta-4-steroids; preparatory processes and pharmaceutical compositions |
US5143909A (en) * | 1991-03-19 | 1992-09-01 | Merrell Dow Pharmaceuticals Inc. | Aminosteroids in a method for inhibiting c17-20 lyase |
EP0794456B1 (en) | 1996-03-07 | 2003-01-29 | Agfa-Gevaert | Method of reproducing an electronically stored medical image on a light-sensitive photographic material |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3917829A (en) * | 1971-11-08 | 1975-11-04 | Research Corp | Novel methods of inhibiting the activity of testosterone 5{60 -reductase |
US4088760A (en) * | 1976-06-23 | 1978-05-09 | Richardson-Merrell Inc. | Testosterone 5α-reductase inhibitors |
-
1980
- 1980-04-21 CA CA000350283A patent/CA1154008A/en not_active Expired
- 1980-04-22 IE IE806/80A patent/IE49704B1/en not_active IP Right Cessation
- 1980-04-23 AU AU57747/80A patent/AU532558B2/en not_active Expired
- 1980-04-24 NZ NZ193527A patent/NZ193527A/xx unknown
- 1980-04-25 GB GB8013775A patent/GB2048888B/en not_active Expired
- 1980-04-28 IL IL59934A patent/IL59934A/xx unknown
- 1980-04-29 SE SE8003242A patent/SE448097B/sv not_active IP Right Cessation
- 1980-04-29 ES ES491010A patent/ES8105012A1/es not_active Expired
- 1980-04-30 AT AT0232880A patent/AT390794B/de not_active IP Right Cessation
- 1980-04-30 CH CH335980A patent/CH643863A5/de not_active IP Right Cessation
- 1980-04-30 FR FR8009848A patent/FR2455610A1/fr active Granted
- 1980-04-30 IT IT48559/80A patent/IT1188932B/it active
- 1980-04-30 NO NO801254A patent/NO154884C/no unknown
- 1980-05-01 DK DK194180A patent/DK166501B1/da not_active IP Right Cessation
- 1980-05-01 NL NL8002529A patent/NL191387C/xx not_active IP Right Cessation
- 1980-05-02 DE DE19803017015 patent/DE3017015A1/de active Granted
Also Published As
Publication number | Publication date |
---|---|
IE49704B1 (en) | 1985-11-27 |
DK194180A (da) | 1980-11-03 |
ES491010A0 (es) | 1981-05-16 |
AU5774780A (en) | 1980-11-06 |
SE8003242L (sv) | 1980-11-03 |
FR2455610A1 (fr) | 1980-11-28 |
ATA232880A (de) | 1989-12-15 |
SE448097B (sv) | 1987-01-19 |
CA1154008A (en) | 1983-09-20 |
DK166501B1 (da) | 1993-06-01 |
IT1188932B (it) | 1988-01-28 |
NO154884C (no) | 1987-01-07 |
IT8048559A1 (it) | 1981-10-30 |
IL59934A (en) | 1983-06-15 |
NL8002529A (nl) | 1980-11-04 |
AT390794B (de) | 1990-06-25 |
NO801254L (no) | 1980-11-03 |
IT8048559A0 (it) | 1980-04-30 |
NO154884B (no) | 1986-09-29 |
NL191387C (nl) | 1995-07-03 |
DE3017015C2 (es) | 1989-04-20 |
IL59934A0 (en) | 1980-06-30 |
DE3017015A1 (de) | 1980-11-20 |
IE800806L (en) | 1980-11-02 |
AU532558B2 (en) | 1983-10-06 |
NZ193527A (en) | 1984-10-19 |
NL191387B (nl) | 1995-02-01 |
CH643863A5 (de) | 1984-06-29 |
GB2048888B (en) | 1983-05-25 |
FR2455610B1 (es) | 1982-04-30 |
GB2048888A (en) | 1980-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20020304 |