ES8104308A1 - Procedimiento para preparar compuestos de cefem - Google Patents
Procedimiento para preparar compuestos de cefemInfo
- Publication number
- ES8104308A1 ES8104308A1 ES492032A ES492032A ES8104308A1 ES 8104308 A1 ES8104308 A1 ES 8104308A1 ES 492032 A ES492032 A ES 492032A ES 492032 A ES492032 A ES 492032A ES 8104308 A1 ES8104308 A1 ES 8104308A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- amino
- protected
- hydroxy
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE CEFEM, DE FORMULA (I), O SUS SALES ACEPTABLES FARMACEUTICAMENTE, DONDE R ELEVADO A 1, R ELEVADO A 2, R ELEVADO A 3 Y R ELEVADO A 4 SON DISTINTOS TIPOS DE RADICALES. SE OBTIENE HACIENDO REACCIONAR UN COMPUESTO DE FORMULA (IV) CON UN COMPUESTO DE TIOL DE FORMULA R ELEVADO A 3 -SH O SU SAL. SE OBTIENEN DISTINTOS TIPOS DE COMPUESTOS SEGUN SE ELIMINAN LOS DISTINTOS GRUPOS PROTECTORES QUE LLEVAN EN LOS DISTINTOS RADICALES. R ELEVADO A 5 SON DISTINTOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACION EN EL TRATAMIENTO DE ENFERMEDADES INFECCIOSAS CAUSADAS POR MICROORGANISMOS PATOGENOS, EN SERES HUMANOS Y ANIMALES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7836399 | 1978-09-11 | ||
GB7908799 | 1979-03-13 | ||
GB7910499 | 1979-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8104308A1 true ES8104308A1 (es) | 1981-04-01 |
ES492032A0 ES492032A0 (es) | 1981-04-01 |
Family
ID=27260589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES483901A Expired ES483901A1 (es) | 1978-09-11 | 1979-09-05 | Un procedimiento para preparar compuestos de cefem |
ES492032A Granted ES492032A0 (es) | 1978-09-11 | 1980-05-30 | Procedimiento para preparar compuestos de cefem |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES483901A Expired ES483901A1 (es) | 1978-09-11 | 1979-09-05 | Un procedimiento para preparar compuestos de cefem |
Country Status (8)
Country | Link |
---|---|
US (3) | US4341775A (es) |
CH (1) | CH650786A5 (es) |
DE (1) | DE2936434A1 (es) |
ES (2) | ES483901A1 (es) |
FR (1) | FR2435479A1 (es) |
IT (1) | IT1123120B (es) |
NL (1) | NL7906780A (es) |
SE (1) | SE450384B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4431643A (en) * | 1976-04-12 | 1984-02-14 | Fujisawa Pharmaceutical Co., Ltd. | Syn-isomer of 3-substituted-7-[2-cyclopentyloxyimino-2-(2-aminothiazol-4-yl)-acetamido]-3 |
BE878433A (fr) * | 1978-08-31 | 1980-02-25 | Fujisawa Pharmaceutical Co | Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
US4458072A (en) * | 1980-10-10 | 1984-07-03 | Hoffmann-La Roche Inc. | Acyl derivatives |
US4618606A (en) * | 1982-11-17 | 1986-10-21 | Toyama Chemical Co., Ltd. | Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins |
FR2546520B1 (fr) * | 1983-05-27 | 1985-08-30 | Sanofi Sa | Nouveaux composes antibiotiques derives des cephalosporines |
GB8401093D0 (en) * | 1984-01-16 | 1984-02-15 | Fujisawa Pharmaceutical Co | Cephem compounds |
GB8504072D0 (en) * | 1985-02-18 | 1985-03-20 | Fujisawa Pharmaceutical Co | Cephem compounds |
AU1630988A (en) * | 1987-05-30 | 1988-12-01 | Kyoto Pharmaceutical Industries, Ltd. | Cephalosporin compound and pharmaceutical composition thereof |
AU617377B2 (en) * | 1987-11-10 | 1991-11-28 | Pharmacia & Upjohn Company | Cephalosporin antibiotics |
US5223496A (en) * | 1987-11-10 | 1993-06-29 | The Upjohn Company | Cephalosporin antibiotics |
KR100449775B1 (ko) * | 1995-11-28 | 2005-08-17 | 동아제약주식회사 | 신규세팔로스포린유도체및그중간체 |
GB0010475D0 (en) * | 2000-04-28 | 2000-06-14 | Biochemie Gmbh | Organic compounds |
TWI335332B (en) | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
WO2003099858A1 (en) * | 2002-05-24 | 2003-12-04 | Theravance, Inc. | Cross-linked glycopeptide-cephalosporin antibiotics |
DE602004024393D1 (de) * | 2003-05-23 | 2010-01-14 | Theravance Inc | Quervernetzte glycopeptid-cephalosporin-antibiotika |
ES2302034T3 (es) * | 2003-07-11 | 2008-07-01 | Theravance, Inc. | Antibioticos de cefalosporina-glicopeptido reticulados. |
UA115087C2 (uk) | 2013-03-13 | 2017-09-11 | ТЕРЕВАНС БАЙОФАРМА АНТІБАЙОТІКС АйПІ, ЕлЕлСі | Кристалічна форма триетиламінової солі заміщеної тіазолілоцтової кислоти |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
BE845338A (fr) * | 1975-09-02 | 1977-02-21 | Nouvelles cephalosporines, procede pour leur obtention et application pharmaceutique | |
US4202893A (en) * | 1976-03-25 | 1980-05-13 | Roussel Uclaf | Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids |
FR2345153A1 (fr) * | 1976-03-25 | 1977-10-21 | Roussel Uclaf | Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
DK162391C (da) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser |
DE2715385A1 (de) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
FR2381053A1 (fr) * | 1977-02-18 | 1978-09-15 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
SE439312B (sv) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
DE2716677C2 (de) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
JPS609719B2 (ja) * | 1977-08-06 | 1985-03-12 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
SE7901262L (sv) * | 1978-02-15 | 1979-08-16 | Fujisawa Pharmaceutical Co | 3,7-disubstituerade 3-cefem-4-karboxylsyraforeningar och forfarande for deras framstellning |
US4220761A (en) * | 1978-09-12 | 1980-09-02 | Fujisawa Pharmaceutical Co., Ltd. | 7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives |
-
1979
- 1979-08-30 US US06/071,302 patent/US4341775A/en not_active Expired - Lifetime
- 1979-09-05 ES ES483901A patent/ES483901A1/es not_active Expired
- 1979-09-07 FR FR7922462A patent/FR2435479A1/fr active Granted
- 1979-09-08 DE DE19792936434 patent/DE2936434A1/de not_active Ceased
- 1979-09-10 CH CH8165/79A patent/CH650786A5/de not_active IP Right Cessation
- 1979-09-10 SE SE7907502A patent/SE450384B/sv not_active IP Right Cessation
- 1979-09-11 IT IT25621/79A patent/IT1123120B/it active
- 1979-09-11 NL NL7906780A patent/NL7906780A/xx not_active Application Discontinuation
-
1980
- 1980-02-20 US US06/123,165 patent/US4366153A/en not_active Expired - Lifetime
- 1980-05-30 ES ES492032A patent/ES492032A0/es active Granted
-
1982
- 1982-05-19 US US06/379,729 patent/US4487767A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2435479A1 (fr) | 1980-04-04 |
US4341775A (en) | 1982-07-27 |
US4487767A (en) | 1984-12-11 |
IT7925621A0 (it) | 1979-09-11 |
IT1123120B (it) | 1986-04-30 |
SE450384B (sv) | 1987-06-22 |
NL7906780A (nl) | 1980-03-13 |
CH650786A5 (de) | 1985-08-15 |
FR2435479B1 (es) | 1983-05-13 |
US4366153A (en) | 1982-12-28 |
ES492032A0 (es) | 1981-04-01 |
SE7907502L (sv) | 1980-04-01 |
ES483901A1 (es) | 1980-10-01 |
DE2936434A1 (de) | 1980-03-20 |
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