ES8104280A1 - Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina - Google Patents
Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidinaInfo
- Publication number
- ES8104280A1 ES8104280A1 ES489627A ES489627A ES8104280A1 ES 8104280 A1 ES8104280 A1 ES 8104280A1 ES 489627 A ES489627 A ES 489627A ES 489627 A ES489627 A ES 489627A ES 8104280 A1 ES8104280 A1 ES 8104280A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- rats
- acid addition
- addition salts
- brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TETRAHIDROPIRIDINA Y PIPERIDINA, DE FORMULA GENERAL (I), DONDE R1 Y R2 SIGNIFICAN HIDROGENO O ALQUILO INFERIOR; Y1 E Y2 PUEDEN SER HIDROGENO O, JUNTOS, UN ENLACE ADICIONAL; EL ANILLO A NO ESTA ULTERIORMENTE SUSTITUIDO O ESTA SUSTITUIDO. SE CARACTERIZA PORQUE EN EL COMPUESTO (II), EL RESTO X SE SUSTITUYE POR HIDROGENO. ESTOS COMPUESTOS TIENEN APLICACION COMO ANTIDEPRESIVOS. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH682378 | 1978-06-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES489627A0 ES489627A0 (es) | 1981-04-01 |
ES8104280A1 true ES8104280A1 (es) | 1981-04-01 |
Family
ID=4315581
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES481714A Expired ES481714A1 (es) | 1978-06-22 | 1979-06-20 | Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina. |
ES489628A Expired ES8104281A1 (es) | 1978-06-22 | 1980-03-17 | Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina |
ES489627A Expired ES8104280A1 (es) | 1978-06-22 | 1980-03-17 | Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES481714A Expired ES481714A1 (es) | 1978-06-22 | 1979-06-20 | Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina. |
ES489628A Expired ES8104281A1 (es) | 1978-06-22 | 1980-03-17 | Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina |
Country Status (10)
Country | Link |
---|---|
US (1) | US4259338A (es) |
EP (1) | EP0006524A1 (es) |
JP (1) | JPS552697A (es) |
AU (1) | AU523656B2 (es) |
CA (1) | CA1119601A (es) |
DD (1) | DD144545A5 (es) |
DK (1) | DK259879A (es) |
ES (3) | ES481714A1 (es) |
NZ (1) | NZ190784A (es) |
ZA (1) | ZA793091B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4455427A (en) * | 1981-07-01 | 1984-06-19 | The Upjohn Company | Pyridyl-substituted-benzofurans |
US4495357A (en) * | 1981-07-01 | 1985-01-22 | The Upjohn Company | Pyridyl-substituted-benzofurans |
US4490531A (en) * | 1981-07-01 | 1984-12-25 | The Upjohn Company | Pyridyl-substituted-benzofurans |
US4447620A (en) * | 1982-06-08 | 1984-05-08 | The Upjohn Company | Imidazolyl-substituted benzothiophenes |
US4452986A (en) * | 1982-06-08 | 1984-06-05 | The Upjohn Company | Imidazolyl-substituted benzofurans |
DD212962A5 (de) * | 1982-10-08 | 1984-08-29 | Ciba Geigy Ag | Verfahren zur herstellung von benzofuranen |
US4855435A (en) * | 1982-10-12 | 1989-08-08 | The Upjohn Company | Pyridyl-substituted benzothiophenes |
US4611059A (en) * | 1982-10-12 | 1986-09-09 | The Upjohn Company | Pyridyl-substituted benzothiophenes |
EP0398413A1 (en) * | 1989-05-16 | 1990-11-22 | Duphar International Research B.V | "3,4-dehydropiperidine derivatives having psychotropic activity |
US5296497A (en) * | 1989-05-16 | 1994-03-22 | Duphar International Research B.V. | 3,4-dehydropiperidine derivatives having psychotropic activity |
EP0404721A3 (de) * | 1989-06-20 | 1991-12-27 | Ciba-Geigy Ag | Mikrobizide Mittel |
DE4017211A1 (de) * | 1990-05-29 | 1991-12-05 | Merck Patent Gmbh | Oxazolidinone |
TW222631B (es) * | 1991-07-15 | 1994-04-21 | Duphar Int Res | |
DK0637586T3 (da) * | 1993-08-05 | 1999-12-06 | Hoechst Marion Roussel Inc | 2-(Piperidin-4-yl, pyridin-4-yl og tetrahydropyridin-4-yl)-benzofuran-7-carbamatderivater, deres fremstilling og anvendelse |
JPH07320652A (ja) * | 1994-05-27 | 1995-12-08 | Toshiba Corp | カラー受像管及びシャドウマスクの製造方法 |
FR2751653B1 (fr) * | 1996-07-25 | 1998-09-04 | Synthelabo | Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique |
FR2739856B1 (fr) * | 1995-10-11 | 1997-11-14 | Synthelabo | Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique |
US5969146A (en) * | 1995-10-11 | 1999-10-19 | Synthelabo | Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof |
FR2741071B1 (fr) * | 1995-11-09 | 1997-12-12 | Synthelabo | Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique |
FR2741072B1 (fr) * | 1995-11-09 | 1997-12-12 | Synthelabo | Derives d'oxazolidin-2-one, leur preparation et leur application en therapeutique |
AU4726699A (en) * | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | Piperidine derivatives having effects on serotonin related systems |
US6881733B1 (en) | 1999-07-29 | 2005-04-19 | Eli Lilly And Company | Serotonergic benzofurans |
JP2003506365A (ja) * | 1999-07-29 | 2003-02-18 | イーライ・リリー・アンド・カンパニー | ベンゾフリルピペラジンおよびベンゾフリルホモピペラジン:セロトニンアゴニスト |
EP1204658B1 (en) * | 1999-07-29 | 2003-05-07 | Eli Lilly And Company | Benzofurylpiperazine serotonin agonists |
JP2003506369A (ja) * | 1999-07-29 | 2003-02-18 | イーライ・リリー・アンド・カンパニー | セロトニン作動性のベンゾフラン |
JP2005008631A (ja) * | 2003-05-29 | 2005-01-13 | New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
US7638540B2 (en) | 2003-05-29 | 2009-12-29 | The New Industry Research Organization | Benzofuran compound and medicinal composition containing the same |
EP2110374A1 (en) * | 2008-04-18 | 2009-10-21 | Merck Sante | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators |
CN101810606A (zh) * | 2010-03-12 | 2010-08-25 | 南方医科大学 | 2-(6-羟基-2′,3′-二甲氧基苯基)-6-羟基-7-甲氧基苯骈呋喃在制备单胺氧化酶抑制剂中的应用 |
CN102381961B (zh) * | 2011-09-03 | 2014-01-15 | 四川大学 | 3-苯基戊二酸类化合物、其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2633468A (en) * | 1951-07-26 | 1953-03-31 | Lilly Co Eli | Benzooxaheterocyclic bases and acid addition salts thereof |
GB1041525A (en) * | 1964-11-11 | 1966-09-07 | Belge Produits Chimiques Sa | Benzofuran derivatives and processes for preparing the same |
US3751390A (en) * | 1971-05-19 | 1973-08-07 | Aldrich Chem Co Inc | Substituted dibenzofuran |
BE794630A (fr) * | 1972-01-26 | 1973-07-26 | Beecham Group Ltd | Composes polycycliques antihypertenseurs |
CH592656A5 (es) * | 1973-03-02 | 1977-10-31 | Ciba Geigy Ag | |
IE39264B1 (en) * | 1973-05-25 | 1978-08-30 | Ciba Geigy Ag | New pharmaceutical preparations |
CH609054A5 (en) * | 1975-11-26 | 1979-02-15 | Ciba Geigy Ag | Process for the preparation of a novel piperidine derivative |
CH605925A5 (es) * | 1974-08-30 | 1978-10-13 | Ciba Geigy Ag | |
LU76756A1 (es) * | 1977-02-11 | 1978-10-18 |
-
1979
- 1979-06-11 EP EP79101887A patent/EP0006524A1/de not_active Withdrawn
- 1979-06-19 DD DD79213724A patent/DD144545A5/de unknown
- 1979-06-20 CA CA000330210A patent/CA1119601A/en not_active Expired
- 1979-06-20 ES ES481714A patent/ES481714A1/es not_active Expired
- 1979-06-21 AU AU48257/79A patent/AU523656B2/en not_active Expired - Fee Related
- 1979-06-21 DK DK259879A patent/DK259879A/da unknown
- 1979-06-21 ZA ZA793091A patent/ZA793091B/xx unknown
- 1979-06-21 NZ NZ190784A patent/NZ190784A/xx unknown
- 1979-06-22 JP JP7828279A patent/JPS552697A/ja active Pending
-
1980
- 1980-03-17 ES ES489628A patent/ES8104281A1/es not_active Expired
- 1980-03-17 ES ES489627A patent/ES8104280A1/es not_active Expired
- 1980-04-14 US US06/140,405 patent/US4259338A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA1119601A (en) | 1982-03-09 |
JPS552697A (en) | 1980-01-10 |
DK259879A (da) | 1979-12-23 |
ES489628A0 (es) | 1981-04-01 |
ES489627A0 (es) | 1981-04-01 |
NZ190784A (en) | 1982-03-16 |
AU4825779A (en) | 1980-01-03 |
DD144545A5 (de) | 1980-10-22 |
EP0006524A1 (de) | 1980-01-09 |
ES8104281A1 (es) | 1981-04-01 |
US4259338A (en) | 1981-03-31 |
ES481714A1 (es) | 1980-06-16 |
AU523656B2 (en) | 1982-08-05 |
ZA793091B (en) | 1980-06-25 |
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