ES8104281A1 - Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina - Google Patents

Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina

Info

Publication number
ES8104281A1
ES8104281A1 ES489628A ES489628A ES8104281A1 ES 8104281 A1 ES8104281 A1 ES 8104281A1 ES 489628 A ES489628 A ES 489628A ES 489628 A ES489628 A ES 489628A ES 8104281 A1 ES8104281 A1 ES 8104281A1
Authority
ES
Spain
Prior art keywords
lower alkyl
rats
acid addition
addition salts
brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489628A
Other languages
English (en)
Other versions
ES489628A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES489628A0 publication Critical patent/ES489628A0/es
Publication of ES8104281A1 publication Critical patent/ES8104281A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TETRAHIDROPIRIDINA Y PIPERIDINA DE FORMULA (I), DONDE R1 Y R2 SIGNIFICAN HIDROGENO O ALQUILO INFERIOR O ALQUILENO INFERIOR; R3 PUEDE SER ALQUILO INFERIOR, ALQUENILO, AQUINILO INFERIOR O CICLOALQUIL-ALQUILO INFERIOR; A NO ESTA ULTERIORMENTE SUSTITUIDO. SE CARACTERIZA PORQUE EN UN COMPUESTO DE FORMULA (II), SE INTRODUCE EL RESTO R3, QUE POSTERIORMENTE SE TRANSFORMA EN UNA SAL. Y1 E Y2 SON DISTINTOS TIPOS DE RADICALES. ESTOS DERIVADOS TIENEN APLICACIONES FARMACOLOGICAS. *FORMULA*
ES489628A 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina Expired ES8104281A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH682378 1978-06-22

Publications (2)

Publication Number Publication Date
ES489628A0 ES489628A0 (es) 1981-04-01
ES8104281A1 true ES8104281A1 (es) 1981-04-01

Family

ID=4315581

Family Applications (3)

Application Number Title Priority Date Filing Date
ES481714A Expired ES481714A1 (es) 1978-06-22 1979-06-20 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina.
ES489627A Expired ES8104280A1 (es) 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina
ES489628A Expired ES8104281A1 (es) 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES481714A Expired ES481714A1 (es) 1978-06-22 1979-06-20 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina.
ES489627A Expired ES8104280A1 (es) 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina

Country Status (10)

Country Link
US (1) US4259338A (es)
EP (1) EP0006524A1 (es)
JP (1) JPS552697A (es)
AU (1) AU523656B2 (es)
CA (1) CA1119601A (es)
DD (1) DD144545A5 (es)
DK (1) DK259879A (es)
ES (3) ES481714A1 (es)
NZ (1) NZ190784A (es)
ZA (1) ZA793091B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455427A (en) * 1981-07-01 1984-06-19 The Upjohn Company Pyridyl-substituted-benzofurans
US4495357A (en) * 1981-07-01 1985-01-22 The Upjohn Company Pyridyl-substituted-benzofurans
US4490531A (en) * 1981-07-01 1984-12-25 The Upjohn Company Pyridyl-substituted-benzofurans
US4452986A (en) * 1982-06-08 1984-06-05 The Upjohn Company Imidazolyl-substituted benzofurans
US4447620A (en) * 1982-06-08 1984-05-08 The Upjohn Company Imidazolyl-substituted benzothiophenes
DD212962A5 (de) * 1982-10-08 1984-08-29 Ciba Geigy Ag Verfahren zur herstellung von benzofuranen
US4611059A (en) * 1982-10-12 1986-09-09 The Upjohn Company Pyridyl-substituted benzothiophenes
US4855435A (en) * 1982-10-12 1989-08-08 The Upjohn Company Pyridyl-substituted benzothiophenes
EP0398413A1 (en) * 1989-05-16 1990-11-22 Duphar International Research B.V "3,4-dehydropiperidine derivatives having psychotropic activity
US5296497A (en) * 1989-05-16 1994-03-22 Duphar International Research B.V. 3,4-dehydropiperidine derivatives having psychotropic activity
EP0404721A3 (de) * 1989-06-20 1991-12-27 Ciba-Geigy Ag Mikrobizide Mittel
DE4017211A1 (de) * 1990-05-29 1991-12-05 Merck Patent Gmbh Oxazolidinone
TW222631B (es) * 1991-07-15 1994-04-21 Duphar Int Res
ES2132284T3 (es) * 1993-08-05 1999-08-16 Hoechst Marion Roussel Inc Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
JPH07320652A (ja) * 1994-05-27 1995-12-08 Toshiba Corp カラー受像管及びシャドウマスクの製造方法
FR2751653B1 (fr) * 1996-07-25 1998-09-04 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
AU7135996A (en) * 1995-10-11 1997-04-30 Synthelabo Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof
FR2739856B1 (fr) * 1995-10-11 1997-11-14 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
FR2741071B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique
FR2741072B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives d'oxazolidin-2-one, leur preparation et leur application en therapeutique
CA2336117A1 (en) 1998-06-30 2000-01-06 Sidney Xi Liang Piperidine derivatives having effects on serotonin related systems
US6881733B1 (en) 1999-07-29 2005-04-19 Eli Lilly And Company Serotonergic benzofurans
JP2003506365A (ja) * 1999-07-29 2003-02-18 イーライ・リリー・アンド・カンパニー ベンゾフリルピペラジンおよびベンゾフリルホモピペラジン：セロトニンアゴニスト
AU768339B2 (en) * 1999-07-29 2003-12-11 Eli Lilly And Company Serotonergic benzofurans
CA2380531A1 (en) * 1999-07-29 2001-02-08 Mark Louis Heiman Benzofurylpiperazine serotonin agonists
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
WO2004106317A1 (ja) * 2003-05-29 2004-12-09 The New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
EP2110374A1 (en) * 2008-04-18 2009-10-21 Merck Sante Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
CN101810606A (zh) * 2010-03-12 2010-08-25 南方医科大学 2-(6-羟基-2′,3′-二甲氧基苯基)-6-羟基-7-甲氧基苯骈呋喃在制备单胺氧化酶抑制剂中的应用
CN102381961B (zh) * 2011-09-03 2014-01-15 四川大学 3-苯基戊二酸类化合物、其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2633468A (en) * 1951-07-26 1953-03-31 Lilly Co Eli Benzooxaheterocyclic bases and acid addition salts thereof
GB1041525A (en) * 1964-11-11 1966-09-07 Belge Produits Chimiques Sa Benzofuran derivatives and processes for preparing the same
US3751390A (en) * 1971-05-19 1973-08-07 Aldrich Chem Co Inc Substituted dibenzofuran
BE794630A (fr) * 1972-01-26 1973-07-26 Beecham Group Ltd Composes polycycliques antihypertenseurs
CH592656A5 (es) * 1973-03-02 1977-10-31 Ciba Geigy Ag
IE39264B1 (en) * 1973-05-25 1978-08-30 Ciba Geigy Ag New pharmaceutical preparations
CH609054A5 (en) * 1975-11-26 1979-02-15 Ciba Geigy Ag Process for the preparation of a novel piperidine derivative
CH605925A5 (es) * 1974-08-30 1978-10-13 Ciba Geigy Ag
LU76756A1 (es) * 1977-02-11 1978-10-18

Also Published As

Publication number Publication date
ZA793091B (en) 1980-06-25
CA1119601A (en) 1982-03-09
NZ190784A (en) 1982-03-16
ES489627A0 (es) 1981-04-01
EP0006524A1 (de) 1980-01-09
ES489628A0 (es) 1981-04-01
JPS552697A (en) 1980-01-10
AU523656B2 (en) 1982-08-05
DK259879A (da) 1979-12-23
US4259338A (en) 1981-03-31
AU4825779A (en) 1980-01-03
ES8104280A1 (es) 1981-04-01
ES481714A1 (es) 1980-06-16
DD144545A5 (de) 1980-10-22

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