ES553529A0 - Un procedimiento para preparar derivados de 4'-desmetil-4-epipodofilotoxina - Google Patents
Un procedimiento para preparar derivados de 4'-desmetil-4-epipodofilotoxinaInfo
- Publication number
- ES553529A0 ES553529A0 ES553529A ES553529A ES553529A0 ES 553529 A0 ES553529 A0 ES 553529A0 ES 553529 A ES553529 A ES 553529A ES 553529 A ES553529 A ES 553529A ES 553529 A0 ES553529 A0 ES 553529A0
- Authority
- ES
- Spain
- Prior art keywords
- epipodofilotoxin
- desmetil
- derivatives
- preparing
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60068424A JPS61227590A (ja) | 1985-04-02 | 1985-04-02 | 新規４′−デメチル−４−エピポドフイロトキシン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES553529A0 true ES553529A0 (es) | 1987-06-16 |
| ES8706713A1 ES8706713A1 (es) | 1987-06-16 |
Family
ID=13373287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES553529A Expired ES8706713A1 (es) | 1985-04-02 | 1986-03-31 | Un procedimiento para preparar derivados de 4'-desmetil-4-epipodofilotoxina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4716221A (es) |
| EP (1) | EP0196618B1 (es) |
| JP (1) | JPS61227590A (es) |
| KR (1) | KR920002140B1 (es) |
| CN (1) | CN1012174B (es) |
| AR (1) | AR242034A1 (es) |
| AT (1) | ATE40826T1 (es) |
| AU (1) | AU574911B2 (es) |
| CA (1) | CA1274510A (es) |
| DE (1) | DE3662104D1 (es) |
| DK (1) | DK169745B1 (es) |
| ES (1) | ES8706713A1 (es) |
| GR (1) | GR860849B (es) |
| IE (1) | IE59046B1 (es) |
| PT (1) | PT82307B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772589A (en) * | 1986-10-29 | 1988-09-20 | Bristol-Myers | Etoposide solution in NMP |
| US4874851A (en) * | 1987-07-01 | 1989-10-17 | Bristol-Meyers Company | 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives |
| US4868291A (en) * | 1987-08-20 | 1989-09-19 | Bristol-Myers Company | 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use |
| US4912204A (en) * | 1988-09-06 | 1990-03-27 | Bristol-Myers Company | Fluoro-substituted epipodophyllotoxin glucosides |
| ES2061891T3 (es) * | 1988-11-16 | 1994-12-16 | Nippon Kayaku Kk | Cristales de dihidrato de dihidrocloruro de compuesto de etoposido-2-dimetilamina y un procedimiento para su produccion. |
| DE3913327A1 (de) * | 1989-04-22 | 1990-10-25 | Behringwerke Ag | Verfahren zur herstellung von glucosaminyl-epi-podo-phyllotoxin-derivaten |
| US4965348A (en) * | 1989-05-19 | 1990-10-23 | Bristol-Myers Company | Dimeric epipodophyllotoxin glucoside derivatives |
| US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
| US5066645A (en) * | 1989-09-01 | 1991-11-19 | Bristol-Myers Company | Epipodophyllotoxin altroside derivatives |
| US5034380A (en) * | 1989-11-20 | 1991-07-23 | Bristol-Myers Squibb Company | Alkoxymethylidene epipodophyllotoxin glucosides |
| KR910014122A (ko) * | 1990-01-19 | 1991-08-31 | 디께다 가즈히꼬 | 에토포시드-2-디메틸아미노 화합물의 동결건조 제제 |
| US5081234A (en) * | 1990-04-30 | 1992-01-14 | Bristol-Myers Squibb Co. | 4'-demethylepipodophyllotoxin glycosides |
| US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
| WO1999032499A1 (en) * | 1997-12-23 | 1999-07-01 | Korea Research Institute Of Chemical Technology | 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| FR2800374B1 (fr) * | 1999-10-28 | 2002-06-28 | Adir | Nouveaux derives de 9-(3,5-dimethoxyphenyl)-5,8,8a,9- tetrahydrofuro[3',4':6,7]naphto[2,3-d] [1,3]dioxol-6(5ah)- one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| KR100418183B1 (ko) * | 2000-01-03 | 2004-02-11 | 한국화학연구원 | 4-Ｏ-[2-(Ｎ,Ｎ-디알킬아미노)-2-데옥시-4,6-Ｏ,Ｏ-(알케닐리덴 또는알키닐리덴)-β-Ｄ-글루코실]-4'-Ｏ-데메틸-에피-포도필로톡신 화합물, 이의 제조방법 및 이를 포함하는 항암제 조성물 |
| KR102378151B1 (ko) | 2020-05-11 | 2022-03-24 | 주식회사 제이앤씨사이언스 | 베타-아포피크로포도필린의 신규한 유도체 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6613143A (es) * | 1965-09-21 | 1967-03-22 | ||
| US4275192A (en) * | 1979-05-03 | 1981-06-23 | G. D. Searle & Co. | Bis(4-demethoxydaunorubicin)dihydrazone derivatives and pharmacologically acceptable salts thereof |
| AU559498B2 (en) * | 1982-02-10 | 1987-03-12 | Nippon Kayaku Kabushiki Kaisha | Production of 4:-demethyl-epipodophyllotoxin-beta-d- ethylidene-glucoside, and derivatives |
| JPS6032799A (ja) * | 1983-07-29 | 1985-02-19 | Microbial Chem Res Found | 新規４′−デメチル−４−エピポドフィロトキシン誘導体 |
-
1985
- 1985-04-02 JP JP60068424A patent/JPS61227590A/ja active Granted
-
1986
- 1986-03-17 KR KR1019860001948A patent/KR920002140B1/ko not_active IP Right Cessation
- 1986-03-21 US US06/842,286 patent/US4716221A/en not_active Expired - Fee Related
- 1986-03-26 DE DE8686104163T patent/DE3662104D1/de not_active Expired
- 1986-03-26 AT AT86104163T patent/ATE40826T1/de not_active IP Right Cessation
- 1986-03-26 EP EP86104163A patent/EP0196618B1/en not_active Expired
- 1986-03-27 IE IE83886A patent/IE59046B1/en not_active IP Right Cessation
- 1986-03-27 CN CN86101960A patent/CN1012174B/zh not_active Expired
- 1986-03-31 AR AR86303522A patent/AR242034A1/es active
- 1986-03-31 GR GR860849A patent/GR860849B/el unknown
- 1986-03-31 ES ES553529A patent/ES8706713A1/es not_active Expired
- 1986-04-01 PT PT82307A patent/PT82307B/pt not_active IP Right Cessation
- 1986-04-01 DK DK146786A patent/DK169745B1/da not_active IP Right Cessation
- 1986-04-01 CA CA000505527A patent/CA1274510A/en not_active Expired - Fee Related
- 1986-04-02 AU AU55574/86A patent/AU574911B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU574911B2 (en) | 1988-07-14 |
| EP0196618B1 (en) | 1989-02-15 |
| CN1012174B (zh) | 1991-03-27 |
| JPS61227590A (ja) | 1986-10-09 |
| AR242034A1 (es) | 1993-02-26 |
| AU5557486A (en) | 1986-10-09 |
| CN86101960A (zh) | 1986-11-12 |
| PT82307B (pt) | 1988-07-29 |
| DK169745B1 (da) | 1995-02-13 |
| KR860008200A (ko) | 1986-11-12 |
| KR920002140B1 (ko) | 1992-03-12 |
| ES8706713A1 (es) | 1987-06-16 |
| ATE40826T1 (de) | 1989-03-15 |
| DK146786A (da) | 1986-10-03 |
| CA1274510A (en) | 1990-09-25 |
| US4716221A (en) | 1987-12-29 |
| IE860838L (en) | 1986-10-02 |
| GR860849B (en) | 1986-07-29 |
| DE3662104D1 (en) | 1989-03-23 |
| IE59046B1 (en) | 1993-12-15 |
| JPH0121155B2 (es) | 1989-04-19 |
| PT82307A (en) | 1986-05-01 |
| EP0196618A1 (en) | 1986-10-08 |
| DK146786D0 (da) | 1986-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990405 |