AU574911B2 - 4' - demethyl - epipodophyllotoxin derivatives - Google Patents

4' - demethyl - epipodophyllotoxin derivatives

Info

Publication number
AU574911B2
AU574911B2 AU55574/86A AU5557486A AU574911B2 AU 574911 B2 AU574911 B2 AU 574911B2 AU 55574/86 A AU55574/86 A AU 55574/86A AU 5557486 A AU5557486 A AU 5557486A AU 574911 B2 AU574911 B2 AU 574911B2
Authority
AU
Australia
Prior art keywords
demethyl
epipodophyllotoxin derivatives
epipodophyllotoxin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU55574/86A
Other versions
AU5557486A (en
Inventor
Shinichi Kondo
Yoshio Nishimura
Tomio Takeuchi
Tomohisa Takita
Wataru Tanaka
Hamao Umezawa
Hiroshi Yoshikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of AU5557486A publication Critical patent/AU5557486A/en
Application granted granted Critical
Publication of AU574911B2 publication Critical patent/AU574911B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU55574/86A 1985-04-02 1986-04-02 4' - demethyl - epipodophyllotoxin derivatives Ceased AU574911B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60-68424 1985-04-02
JP60068424A JPS61227590A (en) 1985-04-02 1985-04-02 Novel 4'-epopodophyllotoxin derivative

Publications (2)

Publication Number Publication Date
AU5557486A AU5557486A (en) 1986-10-09
AU574911B2 true AU574911B2 (en) 1988-07-14

Family

ID=13373287

Family Applications (1)

Application Number Title Priority Date Filing Date
AU55574/86A Ceased AU574911B2 (en) 1985-04-02 1986-04-02 4' - demethyl - epipodophyllotoxin derivatives

Country Status (15)

Country Link
US (1) US4716221A (en)
EP (1) EP0196618B1 (en)
JP (1) JPS61227590A (en)
KR (1) KR920002140B1 (en)
CN (1) CN1012174B (en)
AR (1) AR242034A1 (en)
AT (1) ATE40826T1 (en)
AU (1) AU574911B2 (en)
CA (1) CA1274510A (en)
DE (1) DE3662104D1 (en)
DK (1) DK169745B1 (en)
ES (1) ES8706713A1 (en)
GR (1) GR860849B (en)
IE (1) IE59046B1 (en)
PT (1) PT82307B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622869B2 (en) * 1987-08-20 1992-04-30 Bristol-Myers Squibb Company 4'deshydroxyepipodophyllotoxin glucosides: synthesis and use

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772589A (en) * 1986-10-29 1988-09-20 Bristol-Myers Etoposide solution in NMP
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
DE68912721T2 (en) * 1988-11-16 1994-05-11 Nippon Kayaku Kk Crystalline hydrochloride of an etoposide-2-dimethylamino compound and process for producing the same.
DE3913327A1 (en) * 1989-04-22 1990-10-25 Behringwerke Ag METHOD FOR PRODUCING GLUCOSAMINYL-EPI-PODO-PHYLLOTOXIN DERIVATIVES
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
KR910014122A (en) 1990-01-19 1991-08-31 디께다 가즈히꼬 Lyophilized Formulation of Etoposide-2-dimethylamino Compound
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
FR2800374B1 (en) * 1999-10-28 2002-06-28 Adir NEW DERIVATIVES OF 9- (3,5-DIMETHOXYPHENYL) -5,8,8A, 9- TETRAHYDROFURO [3 ', 4': 6.7] NAPHTO [2,3-D] [1,3] DIOXOL-6 ( 5AH) - ONE, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
KR100418183B1 (en) * 2000-01-03 2004-02-11 한국화학연구원 4-o-[2-(n,n-dialkylamino)-2-deoxy-4,6-o,o-(alkenylidene- or alkynylidene)-beta-d-glucosyl]-4'-o-demethyl-epi-podophyllotoxins, preparation thereof and antitumor composition containing same
KR102378151B1 (en) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 New derivatives of β-apopicropodophyllin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3122484A (en) * 1983-07-29 1985-01-31 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 4:-demethyl - 4 - epipodophyllotoxin derivatives
AU559498B2 (en) * 1982-02-10 1987-03-12 Nippon Kayaku Kabushiki Kaisha Production of 4:-demethyl-epipodophyllotoxin-beta-d- ethylidene-glucoside, and derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (en) * 1965-09-21 1967-03-22
US4275192A (en) * 1979-05-03 1981-06-23 G. D. Searle & Co. Bis(4-demethoxydaunorubicin)dihydrazone derivatives and pharmacologically acceptable salts thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU559498B2 (en) * 1982-02-10 1987-03-12 Nippon Kayaku Kabushiki Kaisha Production of 4:-demethyl-epipodophyllotoxin-beta-d- ethylidene-glucoside, and derivatives
AU3122484A (en) * 1983-07-29 1985-01-31 Zaidan Hojin Biseibutsu Kagaku Kenkyukai 4:-demethyl - 4 - epipodophyllotoxin derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622869B2 (en) * 1987-08-20 1992-04-30 Bristol-Myers Squibb Company 4'deshydroxyepipodophyllotoxin glucosides: synthesis and use

Also Published As

Publication number Publication date
JPS61227590A (en) 1986-10-09
GR860849B (en) 1986-07-29
CN86101960A (en) 1986-11-12
EP0196618B1 (en) 1989-02-15
ES553529A0 (en) 1987-06-16
IE860838L (en) 1986-10-02
CN1012174B (en) 1991-03-27
ATE40826T1 (en) 1989-03-15
PT82307B (en) 1988-07-29
CA1274510A (en) 1990-09-25
DK169745B1 (en) 1995-02-13
AU5557486A (en) 1986-10-09
KR920002140B1 (en) 1992-03-12
DK146786A (en) 1986-10-03
IE59046B1 (en) 1993-12-15
JPH0121155B2 (en) 1989-04-19
KR860008200A (en) 1986-11-12
PT82307A (en) 1986-05-01
EP0196618A1 (en) 1986-10-08
DE3662104D1 (en) 1989-03-23
DK146786D0 (en) 1986-04-01
US4716221A (en) 1987-12-29
ES8706713A1 (en) 1987-06-16
AR242034A1 (en) 1993-02-26

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