ES545330A0 - Un procedimiento para preparar derivados de 1,3-difosfonato - Google Patents
Un procedimiento para preparar derivados de 1,3-difosfonatoInfo
- Publication number
- ES545330A0 ES545330A0 ES545330A ES545330A ES545330A0 ES 545330 A0 ES545330 A0 ES 545330A0 ES 545330 A ES545330 A ES 545330A ES 545330 A ES545330 A ES 545330A ES 545330 A0 ES545330 A0 ES 545330A0
- Authority
- ES
- Spain
- Prior art keywords
- preparing
- procedure
- diphosphonate derivatives
- substituted
- diphosphonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VEFLKXRACNJHOV-UHFFFAOYSA-N 1,3-dibromopropane Chemical class BrCCCBr VEFLKXRACNJHOV-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 abstract 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical group OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH3488/84A CH664158A5 (fr) | 1984-07-18 | 1984-07-18 | Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES545330A0 true ES545330A0 (es) | 1986-12-16 |
| ES8702427A1 ES8702427A1 (es) | 1986-12-16 |
Family
ID=4257079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES545330A Expired ES8702427A1 (es) | 1984-07-18 | 1985-07-17 | Un procedimiento para preparar derivados de 1,3-difosfonato |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4696920A (es) |
| EP (1) | EP0173041B1 (es) |
| JP (1) | JPS6140294A (es) |
| KR (1) | KR930005390B1 (es) |
| AT (1) | ATE38991T1 (es) |
| AU (1) | AU581442B2 (es) |
| CA (1) | CA1284320C (es) |
| CH (1) | CH664158A5 (es) |
| CS (1) | CS262421B2 (es) |
| DE (2) | DE173041T1 (es) |
| DK (1) | DK324185A (es) |
| ES (1) | ES8702427A1 (es) |
| FI (1) | FI79327C (es) |
| GR (1) | GR851767B (es) |
| HU (1) | HU193791B (es) |
| IL (1) | IL75807A (es) |
| NO (1) | NO852822L (es) |
| NZ (1) | NZ212768A (es) |
| PT (1) | PT80820B (es) |
| SU (1) | SU1375141A3 (es) |
| YU (1) | YU117185A (es) |
| ZA (1) | ZA855357B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4639338A (en) * | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US5071840A (en) * | 1986-12-19 | 1991-12-10 | Norwich Eaton Pharmaceuticals, Inc. | Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism |
| NZ226378A (en) * | 1987-10-08 | 1989-12-21 | Colgate Palmolive Co | Packaged dental cream containing polyoxyethylene/polyoxypropylene block copolymer |
| CH675422A5 (es) * | 1988-03-31 | 1990-09-28 | Symphar Sa | |
| US5332743A (en) * | 1992-06-12 | 1994-07-26 | Mcneilab, Inc. | Benzyl and benzhydryl alcohols |
| JPH08502287A (ja) * | 1992-10-09 | 1996-03-12 | ジ・アップジョン・カンパニー | 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸 |
| DE19902924A1 (de) * | 1999-01-26 | 2000-08-03 | Hassan Jomaa | Verwendung von phosphororganischen Verbindungen zur prophylaktischen und therapeutischen Behandlung von Infektionen |
| EP1268498B1 (en) | 2000-02-29 | 2005-04-13 | Medicure International Inc. | Cardioprotective phosphonates |
| US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| WO2002004421A2 (en) | 2000-07-07 | 2002-01-17 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
| US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
| EP1773370A1 (en) * | 2004-07-07 | 2007-04-18 | Medicure International Inc. | Combination therapies employing platelet aggregation drugs |
| US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
| AU2005304220A1 (en) * | 2004-10-28 | 2006-05-18 | Medicure International Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
| US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
| US20070149485A1 (en) * | 2005-11-28 | 2007-06-28 | Medicure International, Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3256370A (en) * | 1962-12-13 | 1966-06-14 | Monsanto Co | Process for preparing alkylene-diphosphonates |
| CA770642A (en) * | 1965-12-02 | 1967-10-31 | Union Carbide Corporation | Phosphine oxides |
| DE2535685A1 (de) * | 1975-08-09 | 1977-02-17 | Bayer Ag | Verfahren zur herstellung von propan-1,3-bis-phosphonyl-verbindungen |
| DE2621604A1 (de) * | 1976-05-14 | 1977-12-01 | Bayer Ag | Substituierte propan-1,3-diphosphonsaeuren und -phosphinsaeuren |
| US4416877A (en) * | 1979-02-13 | 1983-11-22 | Symphar S.A. | Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds |
| GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
| DE3065878D1 (en) * | 1979-07-09 | 1984-01-19 | Elf Aquitaine | Diphosphonic and triphosphonic acid esters, their preparation and applications |
| GB2079285B (en) * | 1980-07-09 | 1984-05-23 | Symphar Sa | Dipthosphonate derivatives and pahrmaceutical compositions containing them |
| US4639338A (en) * | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
-
1984
- 1984-07-18 CH CH3488/84A patent/CH664158A5/fr not_active IP Right Cessation
-
1985
- 1985-07-11 DE DE198585108670T patent/DE173041T1/de active Pending
- 1985-07-11 EP EP85108670A patent/EP0173041B1/en not_active Expired
- 1985-07-11 DE DE8585108670T patent/DE3566545D1/de not_active Expired
- 1985-07-11 AT AT85108670T patent/ATE38991T1/de active
- 1985-07-15 HU HU852714A patent/HU193791B/hu unknown
- 1985-07-15 NO NO852822A patent/NO852822L/no unknown
- 1985-07-15 IL IL75807A patent/IL75807A/xx unknown
- 1985-07-16 ZA ZA855357A patent/ZA855357B/xx unknown
- 1985-07-16 GR GR851767A patent/GR851767B/el unknown
- 1985-07-16 US US06/755,712 patent/US4696920A/en not_active Expired - Fee Related
- 1985-07-17 ES ES545330A patent/ES8702427A1/es not_active Expired
- 1985-07-17 FI FI852806A patent/FI79327C/fi not_active IP Right Cessation
- 1985-07-17 PT PT80820A patent/PT80820B/pt not_active IP Right Cessation
- 1985-07-17 AU AU45114/85A patent/AU581442B2/en not_active Ceased
- 1985-07-17 YU YU01171/85A patent/YU117185A/xx unknown
- 1985-07-17 CS CS855305A patent/CS262421B2/cs unknown
- 1985-07-17 NZ NZ212768A patent/NZ212768A/xx unknown
- 1985-07-17 DK DK324185A patent/DK324185A/da not_active Application Discontinuation
- 1985-07-17 SU SU853926752A patent/SU1375141A3/ru active
- 1985-07-17 CA CA000486929A patent/CA1284320C/en not_active Expired - Fee Related
- 1985-07-18 JP JP15708185A patent/JPS6140294A/ja active Pending
- 1985-07-18 KR KR1019850005129A patent/KR930005390B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| FI79327B (fi) | 1989-08-31 |
| HU193791B (en) | 1987-11-30 |
| SU1375141A3 (ru) | 1988-02-15 |
| DE3566545D1 (en) | 1989-01-05 |
| CS262421B2 (en) | 1989-03-14 |
| FI79327C (fi) | 1989-12-11 |
| FI852806L (fi) | 1986-01-19 |
| AU4511485A (en) | 1986-01-23 |
| EP0173041A1 (en) | 1986-03-05 |
| IL75807A0 (en) | 1985-11-29 |
| US4696920A (en) | 1987-09-29 |
| CA1284320C (en) | 1991-05-21 |
| HUT38950A (en) | 1986-07-28 |
| PT80820B (pt) | 1988-04-21 |
| GR851767B (es) | 1985-11-26 |
| EP0173041B1 (en) | 1988-11-30 |
| ZA855357B (en) | 1986-02-26 |
| ATE38991T1 (de) | 1988-12-15 |
| NZ212768A (en) | 1988-06-30 |
| AU581442B2 (en) | 1989-02-23 |
| CH664158A5 (fr) | 1988-02-15 |
| FI852806A0 (fi) | 1985-07-17 |
| DE173041T1 (de) | 1986-06-12 |
| PT80820A (en) | 1985-08-01 |
| CS530585A2 (en) | 1988-07-15 |
| YU117185A (en) | 1987-10-31 |
| KR860001117A (ko) | 1986-02-22 |
| DK324185D0 (da) | 1985-07-17 |
| JPS6140294A (ja) | 1986-02-26 |
| KR930005390B1 (ko) | 1993-06-19 |
| IL75807A (en) | 1989-09-10 |
| DK324185A (da) | 1986-01-19 |
| ES8702427A1 (es) | 1986-12-16 |
| NO852822L (no) | 1986-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |