ES535491A0 - Un metodo de preparar nuevos derivados de benzoil-urea que tienen actividad anti-tumoral - Google Patents

Un metodo de preparar nuevos derivados de benzoil-urea que tienen actividad anti-tumoral

Info

Publication number
ES535491A0
ES535491A0 ES535491A ES535491A ES535491A0 ES 535491 A0 ES535491 A0 ES 535491A0 ES 535491 A ES535491 A ES 535491A ES 535491 A ES535491 A ES 535491A ES 535491 A0 ES535491 A0 ES 535491A0
Authority
ES
Spain
Prior art keywords
urea derivatives
tumor activity
benzoil
compounds
preparing new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES535491A
Other languages
English (en)
Spanish (es)
Other versions
ES8505338A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Publication of ES8505338A1 publication Critical patent/ES8505338A1/es
Publication of ES535491A0 publication Critical patent/ES535491A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/26—Y being a hydrogen or a carbon atom, e.g. benzoylthioureas

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES535491A 1983-09-01 1984-08-29 Un metodo de preparar nuevos derivados de benzoil-urea que tienen actividad anti-tumoral Granted ES535491A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8303043 1983-09-01

Publications (2)

Publication Number Publication Date
ES8505338A1 ES8505338A1 (es) 1985-05-16
ES535491A0 true ES535491A0 (es) 1985-05-16

Family

ID=19842331

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535491A Granted ES535491A0 (es) 1983-09-01 1984-08-29 Un metodo de preparar nuevos derivados de benzoil-urea que tienen actividad anti-tumoral

Country Status (13)

Country Link
EP (1) EP0136745B1 (da)
JP (1) JPS60120847A (da)
AT (1) ATE43788T1 (da)
AU (1) AU572549B2 (da)
CA (1) CA1252791A (da)
DE (1) DE3478573D1 (da)
DK (1) DK412084A (da)
ES (1) ES535491A0 (da)
GR (1) GR80221B (da)
IL (1) IL72818A0 (da)
NZ (1) NZ209365A (da)
PH (1) PH23038A (da)
ZA (1) ZA846767B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0167197B1 (en) * 1984-07-05 1989-01-18 Duphar International Research B.V Benzoylurea compounds, and insecticidal and acaricidal compositions comprising same
DE3575919D1 (en) * 1984-08-24 1990-03-15 Ciba Geigy Ag Benzoylphenylharnstoffe.
TR23048A (tr) * 1984-08-31 1989-02-14 Ciba Geigy Ag Fenilbenzoiluereler,bunlarin im aline mahsus usul ve bunlarin zararhlarla muecadelede kullanimi
DE3580444D1 (en) * 1984-10-18 1990-12-13 Ciba Geigy Ag Benzoylphenylharnstoffe.
US5153224A (en) * 1984-10-18 1992-10-06 Ciba-Geigy Corporation Benzoylphenylureas
EP0179021A3 (de) * 1984-10-18 1987-05-13 Ciba-Geigy Ag Benzoylphenylharnstoffe
US5135953A (en) * 1984-12-28 1992-08-04 Ciba-Geigy Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals
AU601145B2 (en) * 1985-03-01 1990-09-06 Duphar International Research B.V. Benzoyl urea derivatives having anti-tumor activity
AU602305B2 (en) * 1985-03-14 1990-10-11 Istituto Guido Donegani S.P.A. N-(halobenzoyl)-N-(polyhaloalkoxyphenyl) urea derivatives
JPH0742267B2 (ja) * 1985-06-04 1995-05-10 日本曹達株式会社 ベンゾイルウレア誘導体、その製造方法及び殺虫剤
DE3741062A1 (de) * 1987-12-04 1989-08-31 Hoechst Ag (thio)benzoylharnstoffe und deren funktionelle derivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schaedlingsbekaempfungsmittel
AU642524B2 (en) * 1990-09-10 1993-10-21 Duphar International Research B.V. Pharmaceutical formulation containing a benzoyl urea derivative
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
YU91002A (sh) * 2000-06-09 2006-05-25 Aventis Pharma Deutschland Derivati acilfenil-karbamida, postupak za njihovu proizvodnju i njihova primena kao leka
PE20021091A1 (es) 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
US7223796B2 (en) 2002-04-11 2007-05-29 Sanofi-Aventis Deutschland Gmbh Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use
DE10215907A1 (de) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
US7297709B2 (en) 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
DE10335092B3 (de) * 2003-08-01 2005-02-03 Aventis Pharma Deutschland Gmbh Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
JP5506386B2 (ja) 2006-09-04 2014-05-28 ユニバーシティー・コート・オブ・ザ・ユニバーシティー・オブ・ダンディー Ｐ５３活性化化合物
CN101880246B (zh) * 2009-05-05 2012-10-03 中国科学院上海药物研究所 取代苯甲酰脲类化合物及其制备方法和用途
GB0909912D0 (en) 2009-06-09 2009-07-22 Univ Dundee Compounds
PL2917212T3 (pl) * 2012-11-08 2020-03-31 Rutgers, The State University Of New Jersey Środki przeciwdrobnoustrojowe
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
US10513528B2 (en) 2016-02-25 2019-12-24 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
CA3058183A1 (en) 2017-03-30 2018-10-04 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates
CN113004183B (zh) * 2021-02-08 2023-03-14 中山大学附属第三医院（中山大学肝脏病医院） 一种索拉非尼抗肿瘤抑制助剂化合物及其组合物和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640667A (en) * 1979-09-11 1981-04-16 Ishihara Sangyo Kaisha Ltd Urea derivative
AU1862083A (en) * 1982-09-02 1984-03-08 Duphar International Research B.V. Tumor growth inhibitors
ATE28862T1 (de) * 1983-01-24 1987-08-15 Duphar Int Res Aktive kompositionen gegen motten, weisse fliegen und holzwuermer, pharmazeutische kompositionen und benzoylharnstoffderivaten.
DK147084A (da) * 1983-03-19 1984-09-20 Bayer Ag 1-phenyl-3-benzoyl-(thio)-urinstoffer, deres fremstilling og anvendelse som skadedyrsbekaempelsesmidler
IT1161228B (it) * 1983-04-22 1987-03-18 Montedison Spa Benzoil-uree ad attivita' insetticida

Also Published As

Publication number Publication date
EP0136745A3 (en) 1986-01-22
AU572549B2 (en) 1988-05-12
NZ209365A (en) 1989-07-27
JPS60120847A (ja) 1985-06-28
EP0136745B1 (en) 1989-06-07
GR80221B (en) 1984-12-14
ATE43788T1 (de) 1989-06-15
DE3478573D1 (en) 1989-07-13
ES8505338A1 (es) 1985-05-16
ZA846767B (en) 1985-04-24
DK412084D0 (da) 1984-08-29
CA1252791A (en) 1989-04-18
PH23038A (en) 1989-03-10
EP0136745A2 (en) 1985-04-10
IL72818A0 (en) 1984-11-30
AU3250484A (en) 1985-03-07
DK412084A (da) 1985-03-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505