ES499077A0 - Un procedimiento para la preparacion de nuevos compuestos antihipercolesteremicos - Google Patents
Un procedimiento para la preparacion de nuevos compuestos antihipercolesteremicosInfo
- Publication number
- ES499077A0 ES499077A0 ES499077A ES499077A ES499077A0 ES 499077 A0 ES499077 A0 ES 499077A0 ES 499077 A ES499077 A ES 499077A ES 499077 A ES499077 A ES 499077A ES 499077 A0 ES499077 A0 ES 499077A0
- Authority
- ES
- Spain
- Prior art keywords
- antihypercholesteremic
- compounds
- procedure
- preparation
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/62—Unsaturated compounds containing ether groups, groups, groups, or groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11804880A | 1980-02-04 | 1980-02-04 | |
US06/175,459 US4282155A (en) | 1980-02-04 | 1980-08-05 | Antihypercholesterolemic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES499077A0 true ES499077A0 (es) | 1982-02-01 |
ES8202549A1 ES8202549A1 (es) | 1982-02-01 |
Family
ID=26815915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499077A Expired ES8202549A1 (es) | 1980-02-04 | 1981-02-03 | Un procedimiento para la preparacion de nuevos compuestos antihipercolesteremicos |
Country Status (8)
Country | Link |
---|---|
US (1) | US4282155A (es) |
EP (1) | EP0033536B1 (es) |
DE (1) | DE3165894D1 (es) |
DK (1) | DK46081A (es) |
ES (1) | ES8202549A1 (es) |
GR (1) | GR73078B (es) |
IE (1) | IE51476B1 (es) |
PT (1) | PT72393B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4351844A (en) * | 1980-02-04 | 1982-09-28 | Merck & Co., Inc. | Hypocholesterolemic hydrogenation products and process of preparation |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
US4343814A (en) * | 1980-11-17 | 1982-08-10 | Merck & Co., Inc. | Hypocholesterolemic fermentation products |
US4440927A (en) * | 1981-06-19 | 1984-04-03 | Merck & Co., Inc. | Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase via a chiral synthon |
US4490546A (en) * | 1982-03-25 | 1984-12-25 | Merck & Co., Inc. | Process for 4a'(R),5'-dihydromevinolin |
US4499289A (en) * | 1982-12-03 | 1985-02-12 | G. D. Searle & Co. | Octahydronapthalenes |
US4503072A (en) * | 1982-12-22 | 1985-03-05 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US5208258A (en) * | 1985-10-11 | 1993-05-04 | The Regents Of The University Of California | Antihypercholesterolemic compounds and synthesis thereof |
US4950775A (en) * | 1985-10-11 | 1990-08-21 | University Of California | Antihypercholesterolemic compounds and synthesis thereof |
US4841074A (en) * | 1987-12-11 | 1989-06-20 | Merck & Co., Inc. | Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors |
US5001144A (en) * | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
US4863957A (en) * | 1987-12-21 | 1989-09-05 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
US5001128A (en) * | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
US4904692A (en) * | 1987-12-21 | 1990-02-27 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
US4900754A (en) * | 1987-12-21 | 1990-02-13 | Rorer Pharmaceutical Corp. | HMG-COA reductase inhibitors |
US4939143A (en) * | 1987-12-21 | 1990-07-03 | Rorer Pharmaceutical Corporation | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
US4994494A (en) * | 1987-12-21 | 1991-02-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
US4904691A (en) * | 1987-12-21 | 1990-02-27 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
US5132312A (en) * | 1989-03-27 | 1992-07-21 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US4992429A (en) * | 1989-08-24 | 1991-02-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel HMG-COA reductase inhibitors |
US4946860A (en) * | 1989-11-03 | 1990-08-07 | Rorer Pharmaceutical Corporation | Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors |
WO1991013616A1 (en) * | 1990-03-08 | 1991-09-19 | Rorer International (Overseas) Inc. | NOVEL HMG-CoA REDUCTASE INHIBITORS |
US5443771A (en) * | 1992-09-15 | 1995-08-22 | Gupta; Sankar D. | Ceramic fibre and process therefor |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US6391583B1 (en) | 1998-12-18 | 2002-05-21 | Wisconsin Alumni Research Foundation | Method of producing antihypercholesterolemic agents |
SK282679B6 (sk) * | 1999-04-16 | 2002-11-06 | Biotika, A. S. | Spôsob izolácie lovastatínu z vyfermentovanej pôdy |
IN192861B (es) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
AU2003209990B8 (en) * | 2002-02-25 | 2008-10-30 | Kudos Pharmaceuticals Ltd | Pyranones useful as ATM inhibitors |
CN103012344B (zh) * | 2011-09-28 | 2014-11-12 | 北大方正集团有限公司 | 从洛伐他汀结晶母液中回收洛伐他汀的方法 |
CN102875505B (zh) * | 2012-08-02 | 2015-08-05 | 丽珠集团新北江制药股份有限公司 | 一种美伐他汀的提取精制工艺 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049495A (en) * | 1974-06-07 | 1977-09-20 | Sankyo Company Limited | Physiologically active substances and fermentative process for producing the same |
JPS5612114B2 (es) * | 1974-06-07 | 1981-03-18 | ||
US4137322A (en) * | 1976-11-02 | 1979-01-30 | Sankyo Company Limited | ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents |
IL60219A (en) * | 1979-06-15 | 1985-05-31 | Merck & Co Inc | Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them |
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
-
1980
- 1980-08-05 US US06/175,459 patent/US4282155A/en not_active Expired - Lifetime
-
1981
- 1981-01-23 PT PT72393A patent/PT72393B/pt unknown
- 1981-01-29 IE IE167/81A patent/IE51476B1/en unknown
- 1981-02-02 GR GR64030A patent/GR73078B/el unknown
- 1981-02-02 DE DE8181100727T patent/DE3165894D1/de not_active Expired
- 1981-02-02 EP EP81100727A patent/EP0033536B1/en not_active Expired
- 1981-02-03 ES ES499077A patent/ES8202549A1/es not_active Expired
- 1981-02-03 DK DK46081A patent/DK46081A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US4282155A (en) | 1981-08-04 |
EP0033536A3 (en) | 1982-02-24 |
PT72393B (en) | 1982-09-06 |
IE810167L (en) | 1981-08-04 |
EP0033536B1 (en) | 1984-09-12 |
IE51476B1 (en) | 1987-01-07 |
DE3165894D1 (en) | 1984-10-18 |
DK46081A (da) | 1981-08-05 |
PT72393A (en) | 1981-02-01 |
ES8202549A1 (es) | 1982-02-01 |
GR73078B (es) | 1984-01-31 |
EP0033536A2 (en) | 1981-08-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES499077A0 (es) | Un procedimiento para la preparacion de nuevos compuestos antihipercolesteremicos | |
ES499079A0 (es) | Un procedimiento para la preparacion de un compuesto | |
ES502906A0 (es) | Un procedimiento para la preparacion de nuevos derivados de imidazo-rifamicina | |
ES505517A0 (es) | Un procedimiento para la preparacion de un derivado de n- arilbenzamida | |
ES504103A0 (es) | Un procedimiento para la preparacion de derivados de hidan- toina | |
ES524823A0 (es) | Un procedimiento para la preparacion de nuevas fenetanolaminas | |
ES505950A0 (es) | Un procedimiento para la preparacion de un derivado de tia- zol | |
ES505678A0 (es) | Un procedimiento para la preparacion de un derivado de 3- aril-5-isotiazol | |
ES506141A0 (es) | Un procedimiento para la preparacion de piridin- y pira- cin-derivados | |
ES502792A0 (es) | Un procedimiento para la preparacion de derivados de imida- zol | |
ES502994A0 (es) | Un procedimiento para la preparacion de derivados de pirazo-lopiridacina | |
ES499559A0 (es) | Un procedimiento para la preparacion de derivados de pirrol | |
ES534218A0 (es) | Un procedimiento para la preparacion de compuestos de bencimidazol | |
ES504323A0 (es) | Un procedimiento para la preparacion de un compuesto | |
ES522403A0 (es) | Un procedimiento para la preparacion de nuevos compuestos derivados de aziridina. | |
ES504764A0 (es) | Un procedimiento para la preparacion de un derivado 2-tiope-nem | |
ES504758A0 (es) | Un procedimiento para la preparacion de nuevos derivados de imidazoquinazolinas | |
ES506142A0 (es) | Un procedimiento para la preparacion de nuevos acilderivadosde cefalosporina | |
ES502153A0 (es) | Un procedimiento para la preparacion de compuestos n-acil-n- (cicloalquil) aminoacidos. | |
ES492230A0 (es) | Un procedimiento para la preparacion de nuevos derivados de carbostirilo | |
ES504376A0 (es) | Un procedimiento para la preparacion de un derivado de fene-tilamina | |
ES505019A0 (es) | Un procedimiento para la preparacion de compuestos | |
ES501232A0 (es) | Un procedimiento para la preparacion de fenil-quinolicidinas | |
ES529879A0 (es) | Un procedimiento para la preparacion de nuevos benzonitrilos | |
ES500911A0 (es) | Un procedimiento para la preparacion de derivados de ergoli-na |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960401 |