ES486536A0 - Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico - Google Patents

Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico

Info

Publication number
ES486536A0
ES486536A0 ES486536A ES486536A ES486536A0 ES 486536 A0 ES486536 A0 ES 486536A0 ES 486536 A ES486536 A ES 486536A ES 486536 A ES486536 A ES 486536A ES 486536 A0 ES486536 A0 ES 486536A0
Authority
ES
Spain
Prior art keywords
amino
carboxylic
thioureid
anilids
pirimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES486536A
Other languages
English (en)
Spanish (es)
Other versions
ES8102121A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8102121A1 publication Critical patent/ES8102121A1/es
Publication of ES486536A0 publication Critical patent/ES486536A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pyrrole Compounds (AREA)
ES486536A 1978-12-09 1979-12-03 Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico Granted ES486536A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782853220 DE2853220A1 (de) 1978-12-09 1978-12-09 Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung

Publications (2)

Publication Number Publication Date
ES8102121A1 ES8102121A1 (es) 1980-12-16
ES486536A0 true ES486536A0 (es) 1980-12-16

Family

ID=6056720

Family Applications (3)

Application Number Title Priority Date Filing Date
ES486536A Granted ES486536A0 (es) 1978-12-09 1979-12-03 Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico
ES491224A Expired ES8101068A1 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos
ES491225A Expired ES8101069A1 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de 2,4-diamino-pirimidin-5-carbanilidas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES491224A Expired ES8101068A1 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos
ES491225A Expired ES8101069A1 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de 2,4-diamino-pirimidin-5-carbanilidas

Country Status (9)

Country Link
US (1) US4285946A (member.php)
EP (1) EP0012361B1 (member.php)
JP (1) JPS5581863A (member.php)
AT (1) ATE1288T1 (member.php)
AU (1) AU529426B2 (member.php)
CA (1) CA1136623A (member.php)
DE (2) DE2853220A1 (member.php)
ES (3) ES486536A0 (member.php)
ZA (1) ZA796651B (member.php)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436911A (en) * 1981-05-12 1984-03-13 William H. Rorer, Inc. Heterocyclic amidinoureas
WO1983000627A1 (en) * 1981-08-24 1983-03-03 Studt, William, Lyon Heterocyclic amidino substituted ureas and their pharmaceutical uses
DE3522940A1 (de) * 1985-06-27 1987-01-08 Hoechst Ag 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln
DK0557879T3 (da) * 1992-02-22 1997-06-16 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse
ES2109382T3 (es) * 1992-02-22 1998-01-16 Hoechst Ag Sales solubles de n-metil-n-(3-trifluorometil-fenil)-amida del acido 4-amino-2-(4,4'-dimetil-imidazolidin-2-on-1-il)-pirimidin-5-carboxilico, procedimiento para su preparacion, su utilizacion como medicamento y productos de partida.
DE19625088A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625089A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
ATE314362T1 (de) 1999-10-12 2006-01-15 Takeda Pharmaceutical Pyrimidin-5-carboximidverbindungen, verfahren zur herstellung derselben und deren verwendung
US7176310B1 (en) * 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
US8193206B2 (en) * 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
EP1890703B1 (en) * 2005-06-14 2016-05-11 Taigen Biotechnology Pyrimidine compounds as chemokine receptors inhibitors
AU2009225869B2 (en) 2008-03-18 2014-01-23 Merck Sharp & Dohme Llc Substituted 4-hydroxypyrimidine-5-carboxamides
JP5317263B2 (ja) * 2008-09-24 2013-10-16 株式会社ユニバーサルエンターテインメント 紙葉類処理装置
JP5957537B2 (ja) * 2011-12-21 2016-07-27 ビオタ ヨーロッパ リミテッドＢｉｏｔａ Ｅｕｒｏｐｅ Ｌｔｄ 複素環式ウレア化合物
WO2016161268A1 (en) 2015-04-01 2016-10-06 Enanta Pharmaceuticals, Inc. Hepatitis b antviral agents
US10738035B2 (en) * 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10280175B2 (en) 2016-02-02 2019-05-07 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
MY198617A (en) 2016-03-07 2023-09-11 Enanta Pharm Inc Hepatitis b antiviral agents
BR112018075465A2 (pt) 2016-06-10 2019-03-19 Enanta Pharmaceuticals, Inc. agentes antivirais de hepatite b
WO2019046271A1 (en) 2017-08-28 2019-03-07 Enanta Pharmaceuticals, Inc. ANTIVIRAL AGENTS AGAINST HEPATITIS B
WO2019113175A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TW201927789A (zh) 2017-12-06 2019-07-16 美商因那塔製藥公司 B型肝炎抗病毒試劑
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
TW202024093A (zh) 2018-09-21 2020-07-01 美商安塔製藥公司 作為抗病毒劑之官能化雜環
BR112021009854A2 (pt) 2018-11-21 2021-08-17 Enanta Pharmaceuticals, Inc. heterociclos funcionalizados como agentes antivirais
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031265A (en) * 1963-11-12 1966-06-02 Geigy Co Ltd Tri-tertiary aminopyrimidines and their production
US3479357A (en) * 1967-10-20 1969-11-18 Searle & Co (6 - phenylpyrimidine)mono/bis(1h - 1,2,3-triazole- 4,5-dicarboxylic acid) lower alkyl esters

Also Published As

Publication number Publication date
US4285946A (en) 1981-08-25
ES8102121A1 (es) 1980-12-16
JPS5581863A (en) 1980-06-20
DE2963278D1 (en) 1982-08-19
EP0012361B1 (de) 1982-06-30
AU5357179A (en) 1980-06-12
AU529426B2 (en) 1983-06-09
ATE1288T1 (de) 1982-07-15
EP0012361A1 (de) 1980-06-25
ES491224A0 (es) 1980-12-01
CA1136623A (en) 1982-11-30
DE2853220A1 (de) 1980-07-03
ES491225A0 (es) 1980-12-01
ES8101068A1 (es) 1980-12-01
ZA796651B (en) 1981-05-27
ES8101069A1 (es) 1980-12-01
JPH0457675B2 (member.php) 1992-09-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301