ES485989A1 - Procedimiento para la obtencion de esteres cuajacolicos de acido acetilsalicilico. - Google Patents
Procedimiento para la obtencion de esteres cuajacolicos de acido acetilsalicilico.Info
- Publication number
- ES485989A1 ES485989A1 ES485989A ES485989A ES485989A1 ES 485989 A1 ES485989 A1 ES 485989A1 ES 485989 A ES485989 A ES 485989A ES 485989 A ES485989 A ES 485989A ES 485989 A1 ES485989 A1 ES 485989A1
- Authority
- ES
- Spain
- Prior art keywords
- gaiacol
- salicylic acid
- prod
- pref
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 title abstract 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 title abstract 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- 238000010438 heat treatment Methods 0.000 title abstract 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004889 salicylic acid Drugs 0.000 title abstract 2
- 230000000397 acetylating effect Effects 0.000 title 1
- 229960001138 acetylsalicylic acid Drugs 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 238000005660 chlorination reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 239000012320 chlorinating reagent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/90—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl and carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT29875/78A IT1101712B (it) | 1978-11-16 | 1978-11-16 | Procedimento perfezionato per la preparazione di guaiacolo acetil-salicilato |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES485989A1 true ES485989A1 (es) | 1980-09-01 |
Family
ID=11228593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485989A Expired ES485989A1 (es) | 1978-11-16 | 1979-11-15 | Procedimiento para la obtencion de esteres cuajacolicos de acido acetilsalicilico. |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR223017A1 (fr) |
| ES (1) | ES485989A1 (fr) |
| FR (1) | FR2441606A1 (fr) |
| GR (1) | GR70673B (fr) |
| IT (1) | IT1101712B (fr) |
| PT (1) | PT70451A (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1144813B (it) * | 1981-06-22 | 1986-10-29 | Unione Chimica Medicamenti Dif | Acetilsalicilato di 2 o metossi fenossi etanolo ad attivita analgesica antipiretica ed antiflogistica e suo metodo di preparazione |
| IT1213579B (it) * | 1986-07-03 | 1989-12-20 | Angelo Signor Marino Nicolini | Flogistica. esteri di salsalato con guaiacolo atti al trattamento di broncopneumapatie a base |
| CN103102271B (zh) * | 2012-02-29 | 2014-09-03 | 大连名森制药有限公司 | 一种呱西替柳的工业化制备方法及干混悬剂的医药用途 |
| CN106966899A (zh) * | 2017-03-01 | 2017-07-21 | 山东裕欣药业有限公司 | 一种呱西替柳的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1371887A (fr) * | 1963-07-20 | 1964-09-11 | Ile De France | Nouvel ester de l'acide acétylsalicylique et son procédé de préparation |
-
1978
- 1978-11-16 IT IT29875/78A patent/IT1101712B/it active
-
1979
- 1979-11-14 PT PT70451A patent/PT70451A/pt unknown
- 1979-11-15 GR GR60517A patent/GR70673B/el unknown
- 1979-11-15 ES ES485989A patent/ES485989A1/es not_active Expired
- 1979-11-15 FR FR7928237A patent/FR2441606A1/fr active Granted
- 1979-11-16 AR AR278923A patent/AR223017A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| GR70673B (fr) | 1982-12-06 |
| FR2441606A1 (fr) | 1980-06-13 |
| FR2441606B1 (fr) | 1982-07-16 |
| IT1101712B (it) | 1985-10-07 |
| AR223017A1 (es) | 1981-07-15 |
| IT7829875A0 (it) | 1978-11-16 |
| PT70451A (de) | 1979-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970505 |