ES484283A1 - Procedimiento para la obtencion de 3,4-dihidroisoquinolinas,de efecto antihelmintico - Google Patents
Procedimiento para la obtencion de 3,4-dihidroisoquinolinas,de efecto antihelminticoInfo
- Publication number
- ES484283A1 ES484283A1 ES484283A ES484283A ES484283A1 ES 484283 A1 ES484283 A1 ES 484283A1 ES 484283 A ES484283 A ES 484283A ES 484283 A ES484283 A ES 484283A ES 484283 A1 ES484283 A1 ES 484283A1
- Authority
- ES
- Spain
- Prior art keywords
- production
- dihydroisoquinolin
- benzimidazol
- compounds
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 2
- 229940124339 anthelmintic agent Drugs 0.000 title 1
- 239000000921 anthelmintic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 1
- -1 compound methyl [5-(3,4-dihydroisoquinolin-1-yl)-1H-benzimidazol-2- yl]carbamate Chemical class 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000004987 o-phenylenediamines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1. Procedimiento para la obtención de 3,4- dihidroisoquinolinas, de efecto antihelmintico, de fórmula general: **(Fórmula)** donde R significa alquilo, tal como alquilo C1-C6, R1 y R2 que pueden ser iguales o diferentes significan hidrógeno, halógeno, tal como flúor, cloro y bromo, alquilo, tal como alquilo C1-C6, halogenoalquilo, tal como trifluormetilo, alcoxi, tal como alcoxi C1-C6, alquiltio, alcoxialquiltio, halogenoalcoxi tal como trigluormetoxi o halogenoalquiltio, tal como trifluormetiltio, así como sus sales fisiológicamente compatibles, caracterizado porque se hacen reaccionar en un disolvente o bien mezcla de disolventes adecuada a temperatura de aproximadamente 0 hasta aproximadamente 120ºC ortofenilendiaminas sustituidas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782840927 DE2840927A1 (de) | 1978-09-20 | 1978-09-20 | 3,4-dihydroisochinoline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES484283A1 true ES484283A1 (es) | 1980-05-16 |
Family
ID=6049955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES484283A Expired ES484283A1 (es) | 1978-09-20 | 1979-09-19 | Procedimiento para la obtencion de 3,4-dihidroisoquinolinas,de efecto antihelmintico |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0009174A1 (es) |
| JP (1) | JPS5543094A (es) |
| AU (1) | AU5092679A (es) |
| DE (1) | DE2840927A1 (es) |
| DK (1) | DK391679A (es) |
| ES (1) | ES484283A1 (es) |
| NO (1) | NO792875L (es) |
| ZA (1) | ZA794957B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60131614U (ja) * | 1984-02-14 | 1985-09-03 | ヤンマーディーゼル株式会社 | 内燃機関の排気弁装置 |
| GB9115272D0 (en) * | 1991-07-15 | 1991-08-28 | Pfizer Ltd | Benzimidazole anthelmintics |
| GB9115273D0 (en) * | 1991-07-15 | 1991-08-28 | Pfizer Ltd | Benzimidazole anthelmintics |
| GB9124002D0 (en) * | 1991-11-12 | 1992-01-02 | Pfizer Ltd | Benzimidazole anthelmintic agents |
| JP6161173B2 (ja) * | 2012-04-20 | 2017-07-12 | メリアル インコーポレイテッド | ベンズイミダゾール誘導体を含む殺寄生虫組成物、その方法及び使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE666795A (es) * | 1964-08-04 | 1966-01-13 | ||
| GB1350277A (en) * | 1971-09-22 | 1974-04-18 | Ici Ltd | Process for the manufacture of a benzimidazole derivative |
| IL43396A (en) * | 1972-10-14 | 1976-07-30 | Hoechst Ag | Process for the preparation of 2-benzimidazole-carbamic acid alkyl and benzyl esters |
| US3915986A (en) * | 1974-06-19 | 1975-10-28 | Smithkline Corp | Methyl 5-propylthio-2-benzimidazolecarbamate |
| US4026936A (en) * | 1975-08-07 | 1977-05-31 | Hoffmann-La Roche Inc. | Anthelmintic pyridine and thiazole substituted benzimidazole carbamates |
-
1978
- 1978-09-20 DE DE19782840927 patent/DE2840927A1/de active Pending
-
1979
- 1979-09-05 NO NO792875A patent/NO792875L/no unknown
- 1979-09-05 EP EP79103291A patent/EP0009174A1/de not_active Withdrawn
- 1979-09-18 AU AU50926/79A patent/AU5092679A/en not_active Abandoned
- 1979-09-18 JP JP11888979A patent/JPS5543094A/ja active Pending
- 1979-09-19 ES ES484283A patent/ES484283A1/es not_active Expired
- 1979-09-19 ZA ZA00794957A patent/ZA794957B/xx unknown
- 1979-09-19 DK DK391679A patent/DK391679A/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO792875L (no) | 1980-03-21 |
| EP0009174A1 (de) | 1980-04-02 |
| ZA794957B (en) | 1980-10-29 |
| JPS5543094A (en) | 1980-03-26 |
| DE2840927A1 (de) | 1980-04-10 |
| DK391679A (da) | 1980-03-21 |
| AU5092679A (en) | 1980-03-27 |
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