ES479072A1 - Procedimiento para la obtencion del acetilfenilalanilarginin-etilester. - Google Patents

Procedimiento para la obtencion del acetilfenilalanilarginin-etilester.

Info

Publication number
ES479072A1
ES479072A1 ES479072A ES479072A ES479072A1 ES 479072 A1 ES479072 A1 ES 479072A1 ES 479072 A ES479072 A ES 479072A ES 479072 A ES479072 A ES 479072A ES 479072 A1 ES479072 A1 ES 479072A1
Authority
ES
Spain
Prior art keywords
kallikrein
ethyl ester
arginine
phenylalanine
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479072A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES479072A1 publication Critical patent/ES479072A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96455—Kallikrein (3.4.21.34; 3.4.21.35)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Procedimiento para la obtención del acetilfenilalanil-arginin-etiléster, caracterizado porque N-acetil-L-fenilalanina se hace reaccionar en un disolvente orgánico en presencia de trialquilamina y un reactante aceptor de agua con L-arginetiléster, o bien su hidrocloruro, y el producto de reacción se aisla según métodos usuales.
ES479072A 1978-03-30 1979-03-29 Procedimiento para la obtencion del acetilfenilalanilarginin-etilester. Expired ES479072A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782813772 DE2813772A1 (de) 1978-03-30 1978-03-30 Alpha-n-acetyl-l-phenylalanyl-l- arginin-aethylester

Publications (1)

Publication Number Publication Date
ES479072A1 true ES479072A1 (es) 1979-07-01

Family

ID=6035776

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479072A Expired ES479072A1 (es) 1978-03-30 1979-03-29 Procedimiento para la obtencion del acetilfenilalanilarginin-etilester.

Country Status (7)

Country Link
US (1) US4234477A (es)
EP (1) EP0004589B1 (es)
JP (1) JPS54132549A (es)
AT (1) AT366363B (es)
DE (2) DE2813772A1 (es)
ES (1) ES479072A1 (es)
IL (1) IL56958A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335203A (en) * 1980-07-10 1982-06-15 The Regents Of The University Of California Method for identifying potential contrast media reactors
JPS5753446A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide derivative
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
ITMI20110545A1 (it) * 2011-04-04 2012-10-05 Lundbeck Pharmaceuticals Italy S P A Metodo per la preparazione di intermedi di processo per la sintesi di argatroban monoidrato

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL278010A (es) * 1961-05-04 1900-01-01
US3259617A (en) * 1963-05-24 1966-07-05 Squibb & Sons Inc Process for purification of peptides

Also Published As

Publication number Publication date
JPS54132549A (en) 1979-10-15
ATA230479A (de) 1981-08-15
AT366363B (de) 1982-04-13
US4234477A (en) 1980-11-18
IL56958A0 (en) 1979-05-31
IL56958A (en) 1982-01-31
DE2962080D1 (en) 1982-03-18
EP0004589B1 (de) 1982-02-10
EP0004589A2 (de) 1979-10-17
DE2813772A1 (de) 1979-10-04
EP0004589A3 (en) 1979-10-31

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