ES478011A1 - Un procedimiento de preparacion de nuevos derivados de la bencenopropanamina. - Google Patents
Un procedimiento de preparacion de nuevos derivados de la bencenopropanamina.Info
- Publication number
- ES478011A1 ES478011A1 ES478011A ES478011A ES478011A1 ES 478011 A1 ES478011 A1 ES 478011A1 ES 478011 A ES478011 A ES 478011A ES 478011 A ES478011 A ES 478011A ES 478011 A1 ES478011 A1 ES 478011A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- group
- bromine
- chlorine
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- LYUQWQRTDLVQGA-UHFFFAOYSA-N 3-phenylpropylamine Chemical class NCCCC1=CC=CC=C1 LYUQWQRTDLVQGA-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002891 anorexigenic effect Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000013275 serotonin uptake Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7805335A FR2432500A1 (fr) | 1978-02-24 | 1978-02-24 | Nouveaux derives de la benzene propanamine et leurs sels, procede de preparation et application a titre de medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES478011A1 true ES478011A1 (es) | 1979-07-01 |
Family
ID=9205011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES478011A Expired ES478011A1 (es) | 1978-02-24 | 1979-02-23 | Un procedimiento de preparacion de nuevos derivados de la bencenopropanamina. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4296126A (en, 2012) |
| JP (1) | JPS54122236A (en, 2012) |
| AT (1) | AT362347B (en, 2012) |
| BE (1) | BE874416A (en, 2012) |
| CA (1) | CA1116635A (en, 2012) |
| CH (1) | CH639637A5 (en, 2012) |
| DE (1) | DE2907217C2 (en, 2012) |
| ES (1) | ES478011A1 (en, 2012) |
| FR (1) | FR2432500A1 (en, 2012) |
| GB (1) | GB2017681B (en, 2012) |
| IT (1) | IT1114717B (en, 2012) |
| NL (1) | NL7901457A (en, 2012) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4330546A (en) | 1979-09-14 | 1982-05-18 | John Wyeth & Brother Limited | 3-Aryl-3-aryloxypropylamines |
| US4824868A (en) * | 1982-09-07 | 1989-04-25 | Ciba-Geigy Corporation | Propylamine derivatives useful for the treatment of dementia |
| US4692469A (en) * | 1982-09-07 | 1987-09-08 | Ciba-Geigy Corporation | Propylamine derivatives |
| DK630987D0 (da) * | 1987-12-01 | 1987-12-01 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
| US5166437A (en) * | 1989-03-03 | 1992-11-24 | Orion-Yhtyma Oy | Process for the preparation of fluoxetine |
| DK258389D0 (da) * | 1989-05-26 | 1989-05-26 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
| US5320825A (en) * | 1991-05-01 | 1994-06-14 | Trustees Of The University Of Pennsylvania | Serotonin reuptake inhibitors for S.P.E.C.T. imaging |
| EP0576766A1 (en) * | 1992-06-29 | 1994-01-05 | Novo Nordisk A/S | Propanolamine derivatives, their preparation and use |
| GB0004151D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004153D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004149D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004152D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| US6316672B1 (en) | 2001-01-31 | 2001-11-13 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| US6310250B1 (en) | 2001-01-31 | 2001-10-30 | Grayson Walker Stowell | Form A of fluoxetine hydrochloride |
| US6313350B1 (en) | 2001-01-31 | 2001-11-06 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| US6310251B1 (en) | 2001-01-31 | 2001-10-30 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| US6258853B1 (en) | 2001-01-31 | 2001-07-10 | Grayson Walker Stowell | Form a of fluoxetine hydrochloride |
| LU91038B1 (fr) * | 2001-03-06 | 2003-09-11 | Lilly Co Eli | Inhibiteur d'absorption de monoamines |
| AR035700A1 (es) * | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
| SE0102640D0 (sv) * | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| SE0203304D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Coumpounds |
| US6846957B2 (en) * | 2002-11-22 | 2005-01-25 | Board Of Regents, The University Of Texas System | Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor |
| WO2008081477A1 (en) * | 2007-01-04 | 2008-07-10 | Natco Pharma Limited | 3-aryloxy 3-substituted propanamines |
| US8183266B2 (en) | 2007-06-04 | 2012-05-22 | Intra-Cellular Therapies, Inc. | Methods |
| WO2014046544A1 (en) * | 2012-09-21 | 2014-03-27 | Aapa B.V. | Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2683742A (en) * | 1951-02-23 | 1954-07-13 | Searle & Co | Nu, nu-disubstituted omega-arylmethoxy-omega-arylalkylamine derivatives |
| ES251290A1 (es) * | 1958-08-21 | 1960-04-01 | Parke Davis & Co | Un procedimiento para la producciën de alcohilaminas arilsustituidas |
| US3496195A (en) * | 1966-05-11 | 1970-02-17 | Chinoin Gyogyszer Es Vegyeszet | D-o-bromo-phenyl-isopropyl-methylpropinylamine and its salts |
| GB1343527A (en) * | 1971-07-30 | 1974-01-10 | Cerm Cent Europ Rech Mauvernay | Amino-propanol derivatives |
| US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
| US4018895A (en) * | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
-
1978
- 1978-02-24 FR FR7805335A patent/FR2432500A1/fr active Granted
-
1979
- 1979-02-22 US US06/013,831 patent/US4296126A/en not_active Expired - Lifetime
- 1979-02-23 CA CA000322221A patent/CA1116635A/fr not_active Expired
- 1979-02-23 IT IT48102/79A patent/IT1114717B/it active
- 1979-02-23 BE BE0/193668A patent/BE874416A/xx not_active IP Right Cessation
- 1979-02-23 DE DE2907217A patent/DE2907217C2/de not_active Expired
- 1979-02-23 AT AT143379A patent/AT362347B/de not_active IP Right Cessation
- 1979-02-23 CH CH181979A patent/CH639637A5/fr not_active IP Right Cessation
- 1979-02-23 NL NL7901457A patent/NL7901457A/xx not_active Application Discontinuation
- 1979-02-23 ES ES478011A patent/ES478011A1/es not_active Expired
- 1979-02-23 JP JP1989479A patent/JPS54122236A/ja active Granted
- 1979-02-26 GB GB7906712A patent/GB2017681B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA143379A (de) | 1980-10-15 |
| DE2907217A1 (de) | 1979-08-30 |
| CA1116635A (fr) | 1982-01-19 |
| NL7901457A (nl) | 1979-08-28 |
| BE874416A (fr) | 1979-08-23 |
| FR2432500B1 (en, 2012) | 1981-01-16 |
| IT1114717B (it) | 1986-01-27 |
| FR2432500A1 (fr) | 1980-02-29 |
| JPS638935B2 (en, 2012) | 1988-02-25 |
| GB2017681A (en) | 1979-10-10 |
| US4296126A (en) | 1981-10-20 |
| IT7948102A0 (it) | 1979-02-23 |
| CH639637A5 (fr) | 1983-11-30 |
| JPS54122236A (en) | 1979-09-21 |
| DE2907217C2 (de) | 1985-12-12 |
| GB2017681B (en) | 1982-08-04 |
| AT362347B (de) | 1981-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960506 |