ES476866A1 - Procedimiento de preparacion de isomeros a de nuevos deriva-dos de 20,21-dinoreburnamenina. - Google Patents

Procedimiento de preparacion de isomeros a de nuevos deriva-dos de 20,21-dinoreburnamenina.

Info

Publication number
ES476866A1
ES476866A1 ES476866A ES476866A ES476866A1 ES 476866 A1 ES476866 A1 ES 476866A1 ES 476866 A ES476866 A ES 476866A ES 476866 A ES476866 A ES 476866A ES 476866 A1 ES476866 A1 ES 476866A1
Authority
ES
Spain
Prior art keywords
molecule
formula
dinoreburnamenine
derivatives
dinoreburnamenine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476866A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES476866A1 publication Critical patent/ES476866A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento de preparación de isómeros A de nuevos derivados de 20,21-dinoreburnamenina de la fórmula I: **(Fórmula)** pudiendo tomar el átomo de hidrógeno y el radical hidroxilo en posición 14, una u otra de las orientaciones posibles, a las cuales corresponden los isómeros A y B, estando dichos productos de fórmula I en sus formas racémicas u ópticamente activas, así como de las sales de adición con los ácidos minerales u orgánicos de dichos productos de fórmula I, caracterizado porque se hace reaccionar con un agente básico, bien sea la mezcla de los epímeros A y B, bien sea el epímero B propiamente dicho, llevándose a cabo esta reacción en el seno de un disolvente orgánico a temperatura comprendida entre -20º y la temperatura de reflujo del medio de reacción.
ES476866A 1977-02-22 1979-01-15 Procedimiento de preparacion de isomeros a de nuevos deriva-dos de 20,21-dinoreburnamenina. Expired ES476866A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7705067A FR2381048A1 (fr) 1977-02-22 1977-02-22 Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
ES476866A1 true ES476866A1 (es) 1980-03-01

Family

ID=9187054

Family Applications (2)

Application Number Title Priority Date Filing Date
ES467185A Expired ES467185A1 (es) 1977-02-22 1978-02-21 Procedimiento de preparacion de nuevos derivados de 20,21. dinoreburnamenina.
ES476866A Expired ES476866A1 (es) 1977-02-22 1979-01-15 Procedimiento de preparacion de isomeros a de nuevos deriva-dos de 20,21-dinoreburnamenina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES467185A Expired ES467185A1 (es) 1977-02-22 1978-02-21 Procedimiento de preparacion de nuevos derivados de 20,21. dinoreburnamenina.

Country Status (20)

Country Link
US (1) US4291038A (es)
JP (1) JPS6031833B2 (es)
AT (1) AT357274B (es)
BE (1) BE864173A (es)
CA (1) CA1095520A (es)
CH (1) CH627648A5 (es)
DE (1) DE2807643A1 (es)
DK (1) DK151805C (es)
ES (2) ES467185A1 (es)
FR (1) FR2381048A1 (es)
GB (1) GB1596207A (es)
HU (1) HU176707B (es)
IE (1) IE46466B1 (es)
IL (1) IL54069A (es)
LU (1) LU79099A1 (es)
MX (1) MX5256E (es)
NL (1) NL187397C (es)
PT (1) PT67686B (es)
SE (1) SE436356B (es)
ZA (1) ZA781020B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2433528A2 (fr) * 1978-08-16 1980-03-14 Roussel Uclaf Nouveaux derives de 20,21-dinoreburnamenine, un procede pour leur preparation et leur application comme medicaments
JPS55100383A (en) * 1979-01-25 1980-07-31 Sumitomo Chem Co Ltd Preparation of novel nitrogen-containing polycyclic compound
FR2514357A1 (fr) * 1981-10-08 1983-04-15 Roussel Uclaf Nouveaux derives de 20,21-dinoreburnamenine eventuellement substitues sur le cycle e, procede de preparation et application comme medicaments
HU187139B (en) * 1982-06-30 1985-11-28 Richter Gedeon Vegyeszet Process for preparing new eburnan derivatives
JPH0523158Y2 (es) * 1986-01-28 1993-06-14
FR2623503B1 (es) * 1987-11-19 1991-04-05 Roussel Uclaf
FR2623501B1 (fr) * 1987-11-19 1990-03-16 Roussel Uclaf Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2731154B1 (fr) * 1995-03-03 1997-05-09 Roussel Uclaf Compositions pharmaceutiques comprenant des derives de dinoreburnamenine
FR2865650B1 (fr) * 2004-01-30 2008-06-13 Biocortech Utilisation du 14,15 dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures et les desordres du cycle veille-sommeil
FR2865649A1 (fr) * 2004-01-30 2005-08-05 Biocortech Utilisation du 14,15-dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures
FR2869034B1 (fr) * 2004-04-14 2008-04-04 Biocortech Soc Par Actions Sim Derive du 14,15-dihydro 20,21-dinoreburnamenin 14-ol et leur utilisation pour le traitement des depressions
FR2926077A1 (fr) 2008-01-04 2009-07-10 Servier Lab Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118770B (da) * 1967-08-23 1970-10-05 Richter Gedeon Vegyeszet Fremgangsmåde til fremstilling af vincanol.
US3542796A (en) * 1969-07-07 1970-11-24 Miles Lab Certain hexahydro-1,12-trimethylene-indolo(2,3-a)quinolizines
FR2081587B1 (es) * 1970-03-26 1973-04-06 Anvar
FR2168853B1 (es) * 1972-01-24 1975-04-25 Centre Etd Ind Pharma
HU166766B (es) * 1972-12-08 1975-05-28
JPS5147720A (es) * 1974-10-22 1976-04-23 Komatsu Mfg Co Ltd

Also Published As

Publication number Publication date
AT357274B (de) 1980-06-25
ES467185A1 (es) 1979-06-16
ATA121178A (de) 1979-11-15
CH627648A5 (fr) 1982-01-29
DE2807643A1 (de) 1978-08-24
IL54069A (en) 1982-01-31
SE436356B (sv) 1984-12-03
ZA781020B (en) 1979-03-28
NL187397C (nl) 1991-09-16
DE2807643C2 (es) 1992-04-09
MX5256E (es) 1983-05-23
GB1596207A (en) 1981-08-19
DK75878A (da) 1978-08-23
SE7801153L (sv) 1978-08-23
CA1095520A (fr) 1981-02-10
BE864173A (fr) 1978-08-21
IE46466B1 (en) 1983-06-15
FR2381048A1 (fr) 1978-09-15
AU3346978A (en) 1979-08-30
JPS6031833B2 (ja) 1985-07-24
IE780377L (en) 1978-08-22
FR2381048B1 (es) 1980-12-19
JPS53103500A (en) 1978-09-08
US4291038A (en) 1981-09-22
PT67686A (fr) 1979-05-16
NL187397B (nl) 1991-04-16
IL54069A0 (en) 1978-04-30
HU176707B (en) 1981-04-28
DK151805B (da) 1988-01-04
DK151805C (da) 1988-06-13
LU79099A1 (fr) 1978-09-28
PT67686B (fr) 1980-03-04
NL7801887A (nl) 1978-08-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990301