ES476863A1 - Un procedimiento para la preparacion de nuevos derivados de anilina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de anilina.Info
- Publication number
- ES476863A1 ES476863A1 ES476863A ES476863A ES476863A1 ES 476863 A1 ES476863 A1 ES 476863A1 ES 476863 A ES476863 A ES 476863A ES 476863 A ES476863 A ES 476863A ES 476863 A1 ES476863 A1 ES 476863A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- image
- carbon atoms
- formula
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Derivados de anilina que presentan actividad tranquilizante mayor, a composiciones farmacéuticas que los contienen, al procedimiento para su preparación y a intermediarios útiles en ese procedimiento. La metoclopramida, que es un derivado de cloroanilina de fórmula (I) **fórmula** ha encontrado gran aplicación clínica debido a su capacidad de aumentar la velocidad de vaciado gástrico. Ahora se ha hallado un grupo estructuralmente distinto de derivados de cloroanilina que posee una actividad farmacológica diferente, es decir, una actividad tranquilizante mayor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB16765/77A GB1561023A (en) | 1977-04-22 | 1977-04-22 | 2-methoxy - 5 - chloro aniline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES476863A1 true ES476863A1 (es) | 1979-06-01 |
Family
ID=10083254
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES469008A Expired ES469008A1 (es) | 1977-04-22 | 1978-04-20 | Un procedimiento para la preparacion de nuevos derivados de anilina |
ES476862A Expired ES476862A1 (es) | 1977-04-22 | 1979-01-15 | Un procedimiento para la preparacion de nuevos derivados de anilina. |
ES476864A Expired ES476864A1 (es) | 1977-04-22 | 1979-01-15 | Un procedimiento para la preparacion de nuevos derivados de anilina |
ES476863A Expired ES476863A1 (es) | 1977-04-22 | 1979-01-15 | Un procedimiento para la preparacion de nuevos derivados de anilina. |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES469008A Expired ES469008A1 (es) | 1977-04-22 | 1978-04-20 | Un procedimiento para la preparacion de nuevos derivados de anilina |
ES476862A Expired ES476862A1 (es) | 1977-04-22 | 1979-01-15 | Un procedimiento para la preparacion de nuevos derivados de anilina. |
ES476864A Expired ES476864A1 (es) | 1977-04-22 | 1979-01-15 | Un procedimiento para la preparacion de nuevos derivados de anilina |
Country Status (15)
Country | Link |
---|---|
US (3) | US4223034A (es) |
JP (1) | JPS53132533A (es) |
AU (1) | AU518729B2 (es) |
BE (1) | BE866057A (es) |
CA (1) | CA1136137A (es) |
DE (1) | DE2816884A1 (es) |
DK (1) | DK172578A (es) |
ES (4) | ES469008A1 (es) |
FR (1) | FR2387955A1 (es) |
GB (1) | GB1561023A (es) |
IE (1) | IE46802B1 (es) |
IL (1) | IL54438A (es) |
NL (1) | NL7804203A (es) |
SE (1) | SE7804483L (es) |
ZA (1) | ZA781831B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE431092B (sv) * | 1979-07-10 | 1984-01-16 | Thuresson Af Ekenstam Bo | Terapeutiskt aktiva, substituerade piperidinkarboxianilider |
IL61972A0 (en) * | 1980-01-30 | 1981-02-27 | Beecham Group Ltd | Azabicyclic compounds,their preparation and pharmaceutical compositions containing them |
NZ196324A (en) | 1980-03-01 | 1983-09-02 | Wyeth John & Brother Ltd | Piperidine derivatives and pharmaceutical compositions piperidine and pyridinium intermediates |
IN156879B (es) * | 1980-09-04 | 1985-11-30 | Westinghouse Brake & Signal | |
EP0047620B1 (en) * | 1980-09-10 | 1985-03-13 | Beecham Group Plc | Aryl diazabicyclyl amides, a process for their preparation and use |
US4409225A (en) * | 1981-03-16 | 1983-10-11 | Beecham Group Limited | Substituted benzamides |
US4585774A (en) * | 1981-05-08 | 1986-04-29 | Otsuka Pharmaceutical Co., Ltd. | Aniline derivatives and cardiotonic composition |
GB8517854D0 (en) * | 1985-07-15 | 1985-08-21 | Roussell Lab Ltd | Chemical compounds |
EP0343307A1 (en) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinealkanamine derivatives |
EP0968200A1 (en) * | 1997-02-24 | 2000-01-05 | ZymoGenetics, Inc. | Calcitonin mimetics |
FR2821356A1 (fr) | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
EP1603899B1 (en) | 2003-03-06 | 2009-08-26 | Glaxo Group Limited | Heterocyclic urea derivatives for the treatment of pain |
JP2006519806A (ja) | 2003-03-07 | 2006-08-31 | グラクソ グループ リミテッド | 尿素誘導体および疼痛治療におけるバニロイド受容体拮抗剤としてのそれらの使用。 |
GB0305426D0 (en) * | 2003-03-08 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1189553B (de) * | 1962-08-09 | 1965-03-25 | Degussa | Verfahren zur Herstellung von racemischen und optisch aktiven Piperazinderivaten |
DE1445672A1 (de) * | 1962-08-09 | 1968-12-12 | Degussa | Verfahren zur Herstellung neuer 2-Aryl-alkyl-1-Basen |
US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
US3856857A (en) * | 1970-02-13 | 1974-12-24 | En Nom Collectif Science Union | Amino acids and their derivatives |
US3647877A (en) * | 1970-04-13 | 1972-03-07 | Mead Johnson & Co | Aminopropionanilides |
GB1459506A (en) * | 1974-02-18 | 1976-12-22 | Wyeth John & Brother Ltd | Piperidine derivatives |
GB1458898A (en) * | 1974-03-18 | 1976-12-15 | Science Union & Cie | Ortho alkoxyanilides a process for their preparation and pharmaceutical compositions containing them |
AR216043A1 (es) * | 1974-03-21 | 1979-11-30 | Anphar Sa | Procedimiento para la preparacion de 1-derivados de benzoilamino-4-piperidina y sus sales fisiologicamente aceptables |
JPS518283A (en) * | 1974-07-09 | 1976-01-23 | Kyorin Seiyaku Kk | 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho |
JPS5152176A (es) * | 1974-10-12 | 1976-05-08 | Yoshitomi Pharmaceutical | |
GB1520584A (en) * | 1975-04-02 | 1978-08-09 | Yamanouchi Pharma Co Ltd | 2 - alkoxy - 5 substituted benzamide derivatives and their use in pharmaceutical compositions |
GB1498884A (en) * | 1975-04-15 | 1978-01-25 | Wyeth John & Brother Ltd | Aminoacetamide-pyridyl-tetrahydropyridyl and-piperidyl derivatives |
-
1977
- 1977-04-22 GB GB16765/77A patent/GB1561023A/en not_active Expired
-
1978
- 1978-03-30 ZA ZA00781831A patent/ZA781831B/xx unknown
- 1978-04-03 IL IL54438A patent/IL54438A/xx unknown
- 1978-04-05 CA CA000300476A patent/CA1136137A/en not_active Expired
- 1978-04-10 US US05/894,942 patent/US4223034A/en not_active Expired - Lifetime
- 1978-04-17 BE BE186853A patent/BE866057A/xx unknown
- 1978-04-17 AU AU35169/78A patent/AU518729B2/en not_active Expired
- 1978-04-18 DE DE19782816884 patent/DE2816884A1/de not_active Withdrawn
- 1978-04-18 FR FR7811309A patent/FR2387955A1/fr active Granted
- 1978-04-19 SE SE7804483A patent/SE7804483L/xx unknown
- 1978-04-20 NL NL7804203A patent/NL7804203A/xx not_active Application Discontinuation
- 1978-04-20 DK DK172578A patent/DK172578A/da not_active IP Right Cessation
- 1978-04-20 ES ES469008A patent/ES469008A1/es not_active Expired
- 1978-04-21 JP JP4763078A patent/JPS53132533A/ja active Pending
- 1978-04-21 IE IE791/78A patent/IE46802B1/en unknown
-
1979
- 1979-01-15 ES ES476862A patent/ES476862A1/es not_active Expired
- 1979-01-15 ES ES476864A patent/ES476864A1/es not_active Expired
- 1979-01-15 ES ES476863A patent/ES476863A1/es not_active Expired
-
1980
- 1980-05-12 US US06/148,778 patent/US4331816A/en not_active Expired - Lifetime
- 1980-05-12 US US06/149,182 patent/US4329344A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS53132533A (en) | 1978-11-18 |
ES469008A1 (es) | 1979-09-01 |
DE2816884A1 (de) | 1978-11-02 |
NL7804203A (nl) | 1978-10-24 |
IE780791L (en) | 1978-10-22 |
ZA781831B (en) | 1979-03-28 |
AU518729B2 (en) | 1981-10-15 |
FR2387955B1 (es) | 1982-05-14 |
SE7804483L (sv) | 1978-10-23 |
DK172578A (da) | 1978-10-23 |
CA1136137A (en) | 1982-11-23 |
IL54438A (en) | 1981-10-30 |
BE866057A (fr) | 1978-10-17 |
US4223034A (en) | 1980-09-16 |
AU3516978A (en) | 1979-10-25 |
ES476862A1 (es) | 1979-06-01 |
GB1561023A (en) | 1980-02-13 |
US4329344A (en) | 1982-05-11 |
US4331816A (en) | 1982-05-25 |
ES476864A1 (es) | 1980-06-16 |
IE46802B1 (en) | 1983-09-21 |
IL54438A0 (en) | 1978-07-31 |
FR2387955A1 (fr) | 1978-11-17 |
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