ES475111A1 - Process for the preparation of cyanoacetic acid anilide derivatives - Google Patents

Process for the preparation of cyanoacetic acid anilide derivatives

Info

Publication number
ES475111A1
ES475111A1 ES475111A ES475111A ES475111A1 ES 475111 A1 ES475111 A1 ES 475111A1 ES 475111 A ES475111 A ES 475111A ES 475111 A ES475111 A ES 475111A ES 475111 A1 ES475111 A1 ES 475111A1
Authority
ES
Spain
Prior art keywords
preparation
cyanoacetic acid
acid anilide
anilide derivatives
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475111A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19752555685 external-priority patent/DE2555685A1/en
Priority claimed from DE19752557003 external-priority patent/DE2557003A1/en
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES475111A1 publication Critical patent/ES475111A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Hydroxyethylidenecyanoacetanilides of the formula Ia or their tautomeric form Ib are prepared by reacting cyanoacetone with an appropriately substituted isocyanate. The reaction is carried out at a temperature between -70 and +140 DEG C. The symbols in the formulae Ia and Ib have the meaning stated in the claim. The compounds of the formula Ia and Ib as well as their physiologically tolerated salts have potent anti-inflammatory and analgesic as well as anthelmintic, antimycotic and fungicidal activity.
ES475111A 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives Expired ES475111A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19752555685 DE2555685A1 (en) 1975-12-11 1975-12-11 Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
DE19752557003 DE2557003A1 (en) 1975-12-18 1975-12-18 Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity

Publications (1)

Publication Number Publication Date
ES475111A1 true ES475111A1 (en) 1979-05-01

Family

ID=25769723

Family Applications (6)

Application Number Title Priority Date Filing Date
ES453963A Expired ES453963A2 (en) 1975-12-11 1976-12-04 Process for the preparation of cyanoacetic acid anilide derivatives
ES466542A Expired ES466542A2 (en) 1975-12-11 1978-02-01 Process for the preparation of cyanoacetic acid anilide derivatives
ES475111A Expired ES475111A1 (en) 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives
ES475109A Expired ES475109A1 (en) 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives
ES475108A Expired ES475108A2 (en) 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives
ES475110A Expired ES475110A1 (en) 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES453963A Expired ES453963A2 (en) 1975-12-11 1976-12-04 Process for the preparation of cyanoacetic acid anilide derivatives
ES466542A Expired ES466542A2 (en) 1975-12-11 1978-02-01 Process for the preparation of cyanoacetic acid anilide derivatives

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES475109A Expired ES475109A1 (en) 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives
ES475108A Expired ES475108A2 (en) 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives
ES475110A Expired ES475110A1 (en) 1975-12-11 1978-11-15 Process for the preparation of cyanoacetic acid anilide derivatives

Country Status (12)

Country Link
JP (1) JPS5273830A (en)
CA (1) CA1092133A (en)
CH (6) CH632487A5 (en)
DK (1) DK545976A (en)
ES (6) ES453963A2 (en)
FR (1) FR2334350A2 (en)
GB (1) GB1571990A (en)
IE (1) IE44047B1 (en)
IT (1) IT1124789B (en)
LU (1) LU76354A1 (en)
MX (1) MX4758E (en)
NL (1) NL7613547A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088545B1 (en) * 1982-03-05 1985-12-11 Fbc Limited Fungicidal cyanopropenoates and compositions containing them
DE3534440A1 (en) * 1985-09-27 1987-04-02 Hoechst Ag DRUGS AGAINST CHRONIC GRAFT VERSUS HOST DISEASES AND AUTO AUTO DISEASES, IN PARTICULAR SYSTEMIC LUPUS ERYTHEMATODES
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US6355678B1 (en) 1998-06-29 2002-03-12 Parker Hughes Institute Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
EP2303835A1 (en) * 2008-07-29 2011-04-06 Alembic Limited A process for the preparation of teriflunomide

Also Published As

Publication number Publication date
CH630341A5 (en) 1982-06-15
ES475108A2 (en) 1979-08-01
CA1092133A (en) 1980-12-23
GB1571990A (en) 1980-07-23
IE44047L (en) 1977-06-11
ES475109A1 (en) 1979-04-16
ES453963A2 (en) 1978-05-01
FR2334350B2 (en) 1980-03-07
IT1124789B (en) 1986-05-14
CH632487A5 (en) 1982-10-15
DK545976A (en) 1977-06-12
JPS5273830A (en) 1977-06-21
LU76354A1 (en) 1977-06-24
ES475110A1 (en) 1979-05-01
MX4758E (en) 1982-09-03
IE44047B1 (en) 1981-07-29
FR2334350A2 (en) 1977-07-08
NL7613547A (en) 1977-06-14
CH629756A5 (en) 1982-05-14
CH629755A5 (en) 1982-05-14
ES466542A2 (en) 1979-01-16
CH629757A5 (en) 1982-05-14
CH630342A5 (en) 1982-06-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201