IE44047L - Cyanoacetanilide derivatives. - Google Patents

Cyanoacetanilide derivatives.

Info

Publication number
IE44047L
IE44047L IE762706A IE270676A IE44047L IE 44047 L IE44047 L IE 44047L IE 762706 A IE762706 A IE 762706A IE 270676 A IE270676 A IE 270676A IE 44047 L IE44047 L IE 44047L
Authority
IE
Ireland
Prior art keywords
formula
well
cyanoacetanilide
derivatives
hydroxyethylidenecyanoacetanilides
Prior art date
Application number
IE762706A
Other versions
IE44047B1 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19752555685 external-priority patent/DE2555685A1/en
Priority claimed from DE19752557003 external-priority patent/DE2557003A1/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IE44047L publication Critical patent/IE44047L/en
Publication of IE44047B1 publication Critical patent/IE44047B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Hydroxyethylidenecyanoacetanilides of the formula Ia or their tautomeric form Ib are prepared by reacting cyanoacetone with an appropriately substituted isocyanate. The reaction is carried out at a temperature between -70 and +140 DEG C. The symbols in the formulae Ia and Ib have the meaning stated in the claim. The compounds of the formula Ia and Ib as well as their physiologically tolerated salts have potent anti-inflammatory and analgesic as well as anthelmintic, antimycotic and fungicidal activity. <IMAGE> [GB1571990A]
IE2706/76A 1975-12-11 1976-12-10 Process for the preparation of cyanoacetic acid anilide derivatives IE44047B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19752555685 DE2555685A1 (en) 1975-12-11 1975-12-11 Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity
DE19752557003 DE2557003A1 (en) 1975-12-18 1975-12-18 Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity

Publications (2)

Publication Number Publication Date
IE44047L true IE44047L (en) 1977-06-11
IE44047B1 IE44047B1 (en) 1981-07-29

Family

ID=25769723

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2706/76A IE44047B1 (en) 1975-12-11 1976-12-10 Process for the preparation of cyanoacetic acid anilide derivatives

Country Status (12)

Country Link
JP (1) JPS5273830A (en)
CA (1) CA1092133A (en)
CH (6) CH632487A5 (en)
DK (1) DK545976A (en)
ES (6) ES453963A2 (en)
FR (1) FR2334350A2 (en)
GB (1) GB1571990A (en)
IE (1) IE44047B1 (en)
IT (1) IT1124789B (en)
LU (1) LU76354A1 (en)
MX (1) MX4758E (en)
NL (1) NL7613547A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3361451D1 (en) * 1982-03-05 1986-01-23 Fbc Ltd Fungicidal cyanopropenoates and compositions containing them
DE3534440A1 (en) * 1985-09-27 1987-04-02 Hoechst Ag DRUGS AGAINST CHRONIC GRAFT VERSUS HOST DISEASES AND AUTO AUTO DISEASES, IN PARTICULAR SYSTEMIC LUPUS ERYTHEMATODES
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US6355678B1 (en) 1998-06-29 2002-03-12 Parker Hughes Institute Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
EP2303835A1 (en) 2008-07-29 2011-04-06 Alembic Limited A process for the preparation of teriflunomide

Also Published As

Publication number Publication date
CH630341A5 (en) 1982-06-15
FR2334350B2 (en) 1980-03-07
CH629757A5 (en) 1982-05-14
ES475108A2 (en) 1979-08-01
LU76354A1 (en) 1977-06-24
CH632487A5 (en) 1982-10-15
GB1571990A (en) 1980-07-23
MX4758E (en) 1982-09-03
FR2334350A2 (en) 1977-07-08
ES475111A1 (en) 1979-05-01
IT1124789B (en) 1986-05-14
CH629756A5 (en) 1982-05-14
CA1092133A (en) 1980-12-23
ES466542A2 (en) 1979-01-16
NL7613547A (en) 1977-06-14
ES475109A1 (en) 1979-04-16
DK545976A (en) 1977-06-12
ES453963A2 (en) 1978-05-01
JPS5273830A (en) 1977-06-21
ES475110A1 (en) 1979-05-01
CH630342A5 (en) 1982-06-15
IE44047B1 (en) 1981-07-29
CH629755A5 (en) 1982-05-14

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