ES453963A2 - Process for the preparation of cyanoacetic acid anilide derivatives - Google Patents
Process for the preparation of cyanoacetic acid anilide derivativesInfo
- Publication number
- ES453963A2 ES453963A2 ES453963A ES453963A ES453963A2 ES 453963 A2 ES453963 A2 ES 453963A2 ES 453963 A ES453963 A ES 453963A ES 453963 A ES453963 A ES 453963A ES 453963 A2 ES453963 A2 ES 453963A2
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- cyanoacetic acid
- acid anilide
- anilide derivatives
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Hydroxyethylidenecyanoacetanilides of the formula Ia or their tautomeric form Ib are prepared by reacting cyanoacetone with an appropriately substituted isocyanate. The reaction is carried out at a temperature between -70 and +140 DEG C. The symbols in the formulae Ia and Ib have the meaning stated in the claim. The compounds of the formula Ia and Ib as well as their physiologically tolerated salts have potent anti-inflammatory and analgesic as well as anthelmintic, antimycotic and fungicidal activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752555685 DE2555685A1 (en) | 1975-12-11 | 1975-12-11 | Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity |
| DE19752557003 DE2557003A1 (en) | 1975-12-18 | 1975-12-18 | Hydroxyethylidene-cyano-acetanilides - with antiinflammatory and analgesic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453963A2 true ES453963A2 (en) | 1978-05-01 |
Family
ID=25769723
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453963A Expired ES453963A2 (en) | 1975-12-11 | 1976-12-04 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES466542A Expired ES466542A2 (en) | 1975-12-11 | 1978-02-01 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475111A Expired ES475111A1 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475108A Expired ES475108A2 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475110A Expired ES475110A1 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475109A Expired ES475109A1 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466542A Expired ES466542A2 (en) | 1975-12-11 | 1978-02-01 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475111A Expired ES475111A1 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475108A Expired ES475108A2 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475110A Expired ES475110A1 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
| ES475109A Expired ES475109A1 (en) | 1975-12-11 | 1978-11-15 | Process for the preparation of cyanoacetic acid anilide derivatives |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5273830A (en) |
| CA (1) | CA1092133A (en) |
| CH (6) | CH632487A5 (en) |
| DK (1) | DK545976A (en) |
| ES (6) | ES453963A2 (en) |
| FR (1) | FR2334350A2 (en) |
| GB (1) | GB1571990A (en) |
| IE (1) | IE44047B1 (en) |
| IT (1) | IT1124789B (en) |
| LU (1) | LU76354A1 (en) |
| MX (1) | MX4758E (en) |
| NL (1) | NL7613547A (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3361451D1 (en) * | 1982-03-05 | 1986-01-23 | Fbc Ltd | Fungicidal cyanopropenoates and compositions containing them |
| DE3534440A1 (en) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | DRUGS AGAINST CHRONIC GRAFT VERSUS HOST DISEASES AND AUTO AUTO DISEASES, IN PARTICULAR SYSTEMIC LUPUS ERYTHEMATODES |
| GB8619433D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| GB8619432D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| US6355678B1 (en) | 1998-06-29 | 2002-03-12 | Parker Hughes Institute | Inhibitors of the EGF-receptor tyrosine kinase and methods for their use |
| EP2303835A1 (en) | 2008-07-29 | 2011-04-06 | Alembic Limited | A process for the preparation of teriflunomide |
-
1976
- 1976-12-03 DK DK545976A patent/DK545976A/en not_active Application Discontinuation
- 1976-12-04 ES ES453963A patent/ES453963A2/en not_active Expired
- 1976-12-06 NL NL7613547A patent/NL7613547A/en not_active Application Discontinuation
- 1976-12-09 IT IT30233/76A patent/IT1124789B/en active
- 1976-12-09 LU LU76354A patent/LU76354A1/xx unknown
- 1976-12-10 CH CH1560476A patent/CH632487A5/en not_active IP Right Cessation
- 1976-12-10 MX MX765215U patent/MX4758E/en unknown
- 1976-12-10 CA CA267,670A patent/CA1092133A/en not_active Expired
- 1976-12-10 IE IE2706/76A patent/IE44047B1/en unknown
- 1976-12-11 JP JP51148336A patent/JPS5273830A/en active Pending
- 1976-12-13 FR FR7637514A patent/FR2334350A2/en active Granted
- 1976-12-13 GB GB51910/76A patent/GB1571990A/en not_active Expired
-
1978
- 1978-02-01 ES ES466542A patent/ES466542A2/en not_active Expired
- 1978-11-15 ES ES475111A patent/ES475111A1/en not_active Expired
- 1978-11-15 ES ES475108A patent/ES475108A2/en not_active Expired
- 1978-11-15 ES ES475110A patent/ES475110A1/en not_active Expired
- 1978-11-15 ES ES475109A patent/ES475109A1/en not_active Expired
-
1981
- 1981-04-14 CH CH250481A patent/CH630341A5/en not_active IP Right Cessation
- 1981-04-14 CH CH250581A patent/CH629755A5/en not_active IP Right Cessation
- 1981-04-14 CH CH250681A patent/CH630342A5/en not_active IP Right Cessation
- 1981-04-14 CH CH250781A patent/CH629756A5/en not_active IP Right Cessation
- 1981-04-14 CH CH250881A patent/CH629757A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH630341A5 (en) | 1982-06-15 |
| IE44047L (en) | 1977-06-11 |
| FR2334350B2 (en) | 1980-03-07 |
| CH629757A5 (en) | 1982-05-14 |
| ES475108A2 (en) | 1979-08-01 |
| LU76354A1 (en) | 1977-06-24 |
| CH632487A5 (en) | 1982-10-15 |
| GB1571990A (en) | 1980-07-23 |
| MX4758E (en) | 1982-09-03 |
| FR2334350A2 (en) | 1977-07-08 |
| ES475111A1 (en) | 1979-05-01 |
| IT1124789B (en) | 1986-05-14 |
| CH629756A5 (en) | 1982-05-14 |
| CA1092133A (en) | 1980-12-23 |
| ES466542A2 (en) | 1979-01-16 |
| NL7613547A (en) | 1977-06-14 |
| ES475109A1 (en) | 1979-04-16 |
| DK545976A (en) | 1977-06-12 |
| JPS5273830A (en) | 1977-06-21 |
| ES475110A1 (en) | 1979-05-01 |
| CH630342A5 (en) | 1982-06-15 |
| IE44047B1 (en) | 1981-07-29 |
| CH629755A5 (en) | 1982-05-14 |
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