GB1455522A - Benzopyrano-3,4-c pyridines - Google Patents

Benzopyrano-3,4-c pyridines

Info

Publication number
GB1455522A
GB1455522A GB1095574A GB1095574A GB1455522A GB 1455522 A GB1455522 A GB 1455522A GB 1095574 A GB1095574 A GB 1095574A GB 1095574 A GB1095574 A GB 1095574A GB 1455522 A GB1455522 A GB 1455522A
Authority
GB
United Kingdom
Prior art keywords
compounds
benzopyrano
substituted
alkyl
march
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1095574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority to GB1095574A priority Critical patent/GB1455522A/en
Publication of GB1455522A publication Critical patent/GB1455522A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1455522 Benzopyrano[3,4-c]pyridine derivatives WARNER-LAMBERT CO 12 March 1974 [21 March 1973] 10955/74 Heading C2C The invention comprises compounds of formula and their acid addition salts, wherein R 1 and R 2 are each H, OH or C 1-6 alkoxy; R 3 is H or C 1-6 alkyl; and X is O, S, CH 2 or N-R 4 where R 4 is H or C 1-6 alkyl or alkanoyl. In examples, these compounds are prepared by (1) introducing the heterocyclyl-alkyl group into the 3- position of the corresponding 3-substituted benzopyrano[3,4-c]pyridines [when R 3 #H is desired in the end-product, the starting material is an N - (2 - chloro - 2 - R3 - ethyl) - heterocyclic whereby rearrangement occurs in the course of the reaction]; (2) reacting the methoxysubstituted compounds with HBr to give the corresponding hydroxy-substituted compounds (Ia); or (3) reacting Ia with Et 2 SO 4 to give the corresponding ethoxy-substituted compounds. Therapeutic compositions having bronchodilator activity comprise compounds of the above formula and may be administered orally or parenterally.
GB1095574A 1974-03-12 1974-03-12 Benzopyrano-3,4-c pyridines Expired GB1455522A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1095574A GB1455522A (en) 1974-03-12 1974-03-12 Benzopyrano-3,4-c pyridines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1095574A GB1455522A (en) 1974-03-12 1974-03-12 Benzopyrano-3,4-c pyridines

Publications (1)

Publication Number Publication Date
GB1455522A true GB1455522A (en) 1976-11-10

Family

ID=9977391

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1095574A Expired GB1455522A (en) 1974-03-12 1974-03-12 Benzopyrano-3,4-c pyridines

Country Status (1)

Country Link
GB (1) GB1455522A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087280A2 (en) * 1982-02-23 1983-08-31 Warner-Lambert Company 3-(2-Mono-and dialkylamino)propyl(-1,2,3,4-tetrahydro-5H-(1) benzopyrano(3,4-c)pyridin-5-ones and derivatives thereof, a process for their production, and pharmaceutical compositions containing such compounds
CN113200989A (en) * 2021-05-18 2021-08-03 云南民族大学 Preparation method and application of chromone alkaloid compound

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0087280A2 (en) * 1982-02-23 1983-08-31 Warner-Lambert Company 3-(2-Mono-and dialkylamino)propyl(-1,2,3,4-tetrahydro-5H-(1) benzopyrano(3,4-c)pyridin-5-ones and derivatives thereof, a process for their production, and pharmaceutical compositions containing such compounds
EP0087280A3 (en) * 1982-02-23 1984-07-18 Warner-Lambert Company 3-(2-mono-and dialkylamino)propyl(-1,2,3,4-tetrahydro-5h-(1) benzopyrano(3,4-c)pyridin-5-ones and derivatives thereof, a process for their production, and pharmaceutical compositions containing such compounds
CN113200989A (en) * 2021-05-18 2021-08-03 云南民族大学 Preparation method and application of chromone alkaloid compound

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee