ES471355A1 - Procedimiento de obtencion de r,s-2,3,5,6-tetrahidro-6-fenilimidazo (2,1-b)-tiazole (tetramisole) - Google Patents
Procedimiento de obtencion de r,s-2,3,5,6-tetrahidro-6-fenilimidazo (2,1-b)-tiazole (tetramisole)Info
- Publication number
- ES471355A1 ES471355A1 ES471355A ES471355A ES471355A1 ES 471355 A1 ES471355 A1 ES 471355A1 ES 471355 A ES471355 A ES 471355A ES 471355 A ES471355 A ES 471355A ES 471355 A1 ES471355 A1 ES 471355A1
- Authority
- ES
- Spain
- Prior art keywords
- tetramisole
- preparation
- hydroxyethylaminomethyl
- hydroxyethylamino
- thione
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 title 1
- 229960001614 levamisole Drugs 0.000 title 1
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical compound SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento de obtención de R,S-2,3,5,6- tetrahidro-6-fenil-imidazo (2,1b)- tiazole (Tetramisole). Han sido comunicados un número de métodos de síntesis del tetramisol, en los que, en la mayoría de los casos, tiene lugar la formación de un sistema de anillo tetrahidro-imidazotiazol, formando un enlace entre el átomo de carbono (en la 6ª posición) y el átomo de nitrógeno (en la 7ª posición) (Fórmula I), es decir formación de un enlace (C(6)-N(7), logrado por eliminación de XY en compuestos con la Formula general II **(Fórmula)** en la que X representa OH; -O1, -Br; NHSO2C6CH3-p; -NH2, -NHCOR, mientras que Y muy frecuentemente representa hidrógeno, pero puede representar también RCO- o alquil radical.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG7700036812A BG25138A1 (en) | 1977-07-06 | 1977-07-06 | A method of obtaining of rs-(+/-)-2,3,5,6-tetrahydro-6-phenylimidazo-(2,1-b)-thiazol(tetramizol) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES471355A1 true ES471355A1 (es) | 1979-10-01 |
Family
ID=3903588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471355A Expired ES471355A1 (es) | 1977-07-06 | 1978-07-03 | Procedimiento de obtencion de r,s-2,3,5,6-tetrahidro-6-fenilimidazo (2,1-b)-tiazole (tetramisole) |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5414996A (es) |
| BE (1) | BE868743A (es) |
| BG (1) | BG25138A1 (es) |
| CA (1) | CA1100507A (es) |
| CS (1) | CS199459B1 (es) |
| DE (1) | DE2829823A1 (es) |
| ES (1) | ES471355A1 (es) |
| FR (1) | FR2396760A1 (es) |
| GB (1) | GB2000778B (es) |
| IT (1) | IT1174323B (es) |
| NL (1) | NL7807267A (es) |
| SU (1) | SU920056A1 (es) |
| YU (1) | YU162178A (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105130982B (zh) * | 2015-08-24 | 2017-04-05 | 华南农业大学 | 一种咪唑并杂环氨基二硫代甲酸酯及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3726894A (en) * | 1971-06-24 | 1973-04-10 | American Cyanamid Co | The compound 1-(2-hydroxyethyl)-4-phenyl-2-imidazolidinethione |
| US3865836A (en) * | 1972-12-08 | 1975-02-11 | Janssen Pharmaceutica Nv | Bicyclic imidazoles |
-
1977
- 1977-07-06 BG BG7700036812A patent/BG25138A1/xx unknown
-
1978
- 1978-07-03 ES ES471355A patent/ES471355A1/es not_active Expired
- 1978-07-05 IT IT50169/78A patent/IT1174323B/it active
- 1978-07-05 BE BE2057118A patent/BE868743A/xx not_active IP Right Cessation
- 1978-07-05 SU SU787770242A patent/SU920056A1/ru active
- 1978-07-05 JP JP8247178A patent/JPS5414996A/ja active Pending
- 1978-07-05 NL NL7807267A patent/NL7807267A/xx not_active Application Discontinuation
- 1978-07-05 CA CA306,849A patent/CA1100507A/en not_active Expired
- 1978-07-06 GB GB7829072A patent/GB2000778B/en not_active Expired
- 1978-07-06 DE DE19782829823 patent/DE2829823A1/de not_active Ceased
- 1978-07-06 YU YU01621/78A patent/YU162178A/xx unknown
- 1978-07-06 CS CS784514A patent/CS199459B1/cs unknown
- 1978-07-06 FR FR7820187A patent/FR2396760A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SU920056A1 (ru) | 1982-04-15 |
| CA1100507A (en) | 1981-05-05 |
| IT7850169A0 (it) | 1978-07-05 |
| BG25138A1 (en) | 1978-08-10 |
| FR2396760B1 (es) | 1981-12-18 |
| IT1174323B (it) | 1987-07-01 |
| CS199459B1 (en) | 1980-07-31 |
| GB2000778B (en) | 1982-04-07 |
| FR2396760A1 (fr) | 1979-02-02 |
| JPS5414996A (en) | 1979-02-03 |
| NL7807267A (nl) | 1979-01-09 |
| BE868743A (fr) | 1978-11-03 |
| YU162178A (en) | 1982-08-31 |
| GB2000778A (en) | 1979-01-17 |
| DE2829823A1 (de) | 1979-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001009 |