ES469391A1 - Novel pyranoquinoline derivative and method for its production and composition containing same - Google Patents

Novel pyranoquinoline derivative and method for its production and composition containing same

Info

Publication number
ES469391A1
ES469391A1 ES469391A ES469391A ES469391A1 ES 469391 A1 ES469391 A1 ES 469391A1 ES 469391 A ES469391 A ES 469391A ES 469391 A ES469391 A ES 469391A ES 469391 A1 ES469391 A1 ES 469391A1
Authority
ES
Spain
Prior art keywords
compound
novel
production
composition containing
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469391A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of ES469391A1 publication Critical patent/ES469391A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PURPOSE: To obtain a medicinal composition useful for inhibiting an obstruction of airway or an excessive secretion of mucus, containing a specific pyranoquinoline derivative. CONSTITUTION: This composition contains 9-ethyl-6,9-dihydro-4,6-dioxo-10propyl-4 H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid as an active component. An administration dose is 0.001-50mg per 1kg of body weight or 0.01-1,000mg, especially 1-60mg per 1 day for a person. The compound of formula I is produced by selectively hydrolyzing or oxidizing a compound of formula II (D and D) are each a group capable of being hydrolyzed or oxidized to COOH, or either is the above group and the other is COOH), or cyclizing a compound of formula III or IV.
ES469391A 1977-05-04 1978-05-03 Novel pyranoquinoline derivative and method for its production and composition containing same Expired ES469391A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1859777 1977-05-04
GB4586577 1977-11-04

Publications (1)

Publication Number Publication Date
ES469391A1 true ES469391A1 (en) 1979-10-01

Family

ID=26253475

Family Applications (1)

Application Number Title Priority Date Filing Date
ES469391A Expired ES469391A1 (en) 1977-05-04 1978-05-03 Novel pyranoquinoline derivative and method for its production and composition containing same

Country Status (16)

Country Link
JP (2) JPS53137969A (en)
AU (1) AU520816B2 (en)
CA (1) CA1112644A (en)
CH (1) CH634071A5 (en)
DE (1) DE2819215A1 (en)
DK (1) DK158266C (en)
ES (1) ES469391A1 (en)
FR (1) FR2389627B1 (en)
IE (1) IE47051B1 (en)
IL (2) IL54614A (en)
IT (1) IT1158699B (en)
LU (2) LU79579A1 (en)
NL (2) NL184896C (en)
NO (1) NO154497C (en)
NZ (1) NZ187156A (en)
SE (2) SE443561B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440371A1 (en) * 1978-10-31 1980-05-30 Fisons Ltd NOVEL HETEROCYCLIC NITROGEN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHODS FOR PREPARING THE SAME
ATE11774T1 (en) * 1979-12-07 1985-02-15 Fisons Plc PROCESSES FOR THE PREPARATION OF 1,4-DIHYDRO-4-OXO-QUINOLINE-2-CARBONIC ACIDS OR SALTS, ESTERS OR AMIDES THEREOF AND INTERMEDIATE COMPOUNDS THEREOF.
EP0162556B1 (en) * 1984-04-13 1991-11-06 FISONS plc Novels forms and formulations of nedocromil sodium
EP0279121B1 (en) * 1986-12-23 1993-09-01 FISONS plc Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2054503A1 (en) * 1969-07-18 1971-04-23 Bellon Labor Sa Roger 1, 4-dihydro-4-oxo quinolyl-3-carboxylic aci

Also Published As

Publication number Publication date
IE47051B1 (en) 1983-12-14
SE463920B (en) 1991-02-11
IT7822918A0 (en) 1978-05-02
AU520816B2 (en) 1982-03-04
FR2389627B1 (en) 1981-01-02
AU3573178A (en) 1979-11-08
NL184896B (en) 1989-07-03
DK158266C (en) 1990-10-08
DK158266B (en) 1990-04-23
IL54614A (en) 1983-07-31
NL930050I1 (en) 1993-09-01
NL930050I2 (en) 1993-11-16
LU79579A1 (en) 1979-02-02
SE8602492L (en) 1986-06-02
NZ187156A (en) 1984-03-30
IL61826A0 (en) 1981-01-30
NL184896C (en) 1989-12-01
JPH01199909A (en) 1989-08-11
NO154497B (en) 1986-06-23
LU88281I2 (en) 1994-05-04
CA1112644A (en) 1981-11-17
IT1158699B (en) 1987-02-25
CH634071A5 (en) 1983-01-14
FR2389627A1 (en) 1978-12-01
NO154497C (en) 1986-10-01
JPH0122276B2 (en) 1989-04-25
DE2819215A1 (en) 1978-11-16
IE780890L (en) 1978-11-04
NL7804749A (en) 1978-11-07
NO781549L (en) 1978-11-07
IL54614A0 (en) 1978-07-31
SE7805105L (en) 1978-11-05
DE2819215C2 (en) 1990-12-13
SE443561B (en) 1986-03-03
DK190178A (en) 1978-11-05
SE8602492D0 (en) 1986-06-02
JPS53137969A (en) 1978-12-01

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