SE8602492L - INTERMEDIATE - Google Patents

INTERMEDIATE

Info

Publication number
SE8602492L
SE8602492L SE8602492A SE8602492A SE8602492L SE 8602492 L SE8602492 L SE 8602492L SE 8602492 A SE8602492 A SE 8602492A SE 8602492 A SE8602492 A SE 8602492A SE 8602492 L SE8602492 L SE 8602492L
Authority
SE
Sweden
Prior art keywords
alkyl
compounds
hydrogen
alkenyl
different
Prior art date
Application number
SE8602492A
Other languages
Swedish (sv)
Other versions
SE8602492D0 (en
SE463920B (en
Inventor
H Cairns
D Cox
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Ltd filed Critical Fisons Ltd
Publication of SE8602492D0 publication Critical patent/SE8602492D0/en
Publication of SE8602492L publication Critical patent/SE8602492L/en
Publication of SE463920B publication Critical patent/SE463920B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Abstract

DIOXOPYRANOQUINOLINE DICARBOXYLIC ACID DERIVATIVES There are described compounds of formula I I in which an adjacent pair of R5, R6, R7 and R8 form a chain -COCH=CE-O-, and the remainder of R5, R6, R7 and R8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or -NR1R2 in which R1 and R2, which are the same or different, are each hydrogen or alkyl, Rg is hydrogen, alkyl, alkenyl or phenyl-alkyl, and E is -COOH, a 5-tetrazolyl group or an (N-tetra-5-yl) carboxamido group, and phrmaceutically acceptable derivatives thereof. There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
SE8602492A 1977-05-04 1986-06-02 INTERMEDIATE FOR USE IN THE PREPARATION OF THERAPEUTICALLY EFFECTIVE PYRANOKINOLINO DERIVATIVES SE463920B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1859777 1977-05-04
GB4586577 1977-11-04

Publications (3)

Publication Number Publication Date
SE8602492D0 SE8602492D0 (en) 1986-06-02
SE8602492L true SE8602492L (en) 1986-06-02
SE463920B SE463920B (en) 1991-02-11

Family

ID=26253475

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7805105A SE443561B (en) 1977-05-04 1978-05-03 PROCEDURE FOR PREPARING PYRANOQINOLINE DERIVATIVES WITH THERAPEUTIC EFFECT
SE8602492A SE463920B (en) 1977-05-04 1986-06-02 INTERMEDIATE FOR USE IN THE PREPARATION OF THERAPEUTICALLY EFFECTIVE PYRANOKINOLINO DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7805105A SE443561B (en) 1977-05-04 1978-05-03 PROCEDURE FOR PREPARING PYRANOQINOLINE DERIVATIVES WITH THERAPEUTIC EFFECT

Country Status (16)

Country Link
JP (2) JPS53137969A (en)
AU (1) AU520816B2 (en)
CA (1) CA1112644A (en)
CH (1) CH634071A5 (en)
DE (1) DE2819215A1 (en)
DK (1) DK158266C (en)
ES (1) ES469391A1 (en)
FR (1) FR2389627B1 (en)
IE (1) IE47051B1 (en)
IL (2) IL54614A (en)
IT (1) IT1158699B (en)
LU (2) LU79579A1 (en)
NL (2) NL184896C (en)
NO (1) NO154497C (en)
NZ (1) NZ187156A (en)
SE (2) SE443561B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440371A1 (en) * 1978-10-31 1980-05-30 Fisons Ltd NOVEL HETEROCYCLIC NITROGEN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHODS FOR PREPARING THE SAME
ATE11774T1 (en) * 1979-12-07 1985-02-15 Fisons Plc PROCESSES FOR THE PREPARATION OF 1,4-DIHYDRO-4-OXO-QUINOLINE-2-CARBONIC ACIDS OR SALTS, ESTERS OR AMIDES THEREOF AND INTERMEDIATE COMPOUNDS THEREOF.
EP0162556B1 (en) * 1984-04-13 1991-11-06 FISONS plc Novels forms and formulations of nedocromil sodium
EP0279121B1 (en) * 1986-12-23 1993-09-01 FISONS plc Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2054503A1 (en) * 1969-07-18 1971-04-23 Bellon Labor Sa Roger 1, 4-dihydro-4-oxo quinolyl-3-carboxylic aci

Also Published As

Publication number Publication date
NL930050I2 (en) 1993-11-16
NO781549L (en) 1978-11-07
SE8602492D0 (en) 1986-06-02
FR2389627B1 (en) 1981-01-02
IL54614A0 (en) 1978-07-31
NL184896B (en) 1989-07-03
JPH0122276B2 (en) 1989-04-25
CA1112644A (en) 1981-11-17
IL61826A0 (en) 1981-01-30
IT1158699B (en) 1987-02-25
SE7805105L (en) 1978-11-05
NL184896C (en) 1989-12-01
IE780890L (en) 1978-11-04
ES469391A1 (en) 1979-10-01
DK158266C (en) 1990-10-08
SE463920B (en) 1991-02-11
IT7822918A0 (en) 1978-05-02
IL54614A (en) 1983-07-31
SE443561B (en) 1986-03-03
FR2389627A1 (en) 1978-12-01
CH634071A5 (en) 1983-01-14
DK190178A (en) 1978-11-05
NZ187156A (en) 1984-03-30
AU520816B2 (en) 1982-03-04
NL7804749A (en) 1978-11-07
NO154497C (en) 1986-10-01
LU88281I2 (en) 1994-05-04
LU79579A1 (en) 1979-02-02
DE2819215A1 (en) 1978-11-16
DK158266B (en) 1990-04-23
IE47051B1 (en) 1983-12-14
DE2819215C2 (en) 1990-12-13
NO154497B (en) 1986-06-23
NL930050I1 (en) 1993-09-01
JPS53137969A (en) 1978-12-01
JPH01199909A (en) 1989-08-11
AU3573178A (en) 1979-11-08

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