ES8502987A1 - Benzo(b)thiophenes. - Google Patents

Benzo(b)thiophenes.

Info

Publication number
ES8502987A1
ES8502987A1 ES524980A ES524980A ES8502987A1 ES 8502987 A1 ES8502987 A1 ES 8502987A1 ES 524980 A ES524980 A ES 524980A ES 524980 A ES524980 A ES 524980A ES 8502987 A1 ES8502987 A1 ES 8502987A1
Authority
ES
Spain
Prior art keywords
thiophenes
benzo
compositions
chem
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524980A
Other languages
Spanish (es)
Other versions
ES524980A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of ES524980A0 publication Critical patent/ES524980A0/en
Publication of ES8502987A1 publication Critical patent/ES8502987A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes

Abstract

Benzo (b) thiophenes, compositions containing same, process for the preparation thereof, methods of reducing blood pressure and producing diuresis by the administration of the compounds, compositions and various intermediates, the benzo (b) thiophenes having the formula < CHEM >
ES524980A 1980-10-20 1983-08-16 Benzo(b)thiophenes. Expired ES8502987A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19873680A 1980-10-20 1980-10-20
US06/256,470 US4436748A (en) 1980-10-20 1981-04-22 Benzo[b]thiophenes

Publications (2)

Publication Number Publication Date
ES524980A0 ES524980A0 (en) 1985-02-01
ES8502987A1 true ES8502987A1 (en) 1985-02-01

Family

ID=26894105

Family Applications (3)

Application Number Title Priority Date Filing Date
ES506228A Granted ES506228A0 (en) 1980-10-20 1981-10-14 PROCEDURE FOR THE PREPARATION OF NEW BENZO (B) TIOFE-NOS
ES515436A Granted ES515436A0 (en) 1980-10-20 1982-09-01 "PROCEDURE TO PREPARE NEW BENZO B THIOPHENES".
ES524980A Expired ES8502987A1 (en) 1980-10-20 1983-08-16 Benzo(b)thiophenes.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES506228A Granted ES506228A0 (en) 1980-10-20 1981-10-14 PROCEDURE FOR THE PREPARATION OF NEW BENZO (B) TIOFE-NOS
ES515436A Granted ES515436A0 (en) 1980-10-20 1982-09-01 "PROCEDURE TO PREPARE NEW BENZO B THIOPHENES".

Country Status (13)

Country Link
US (1) US4436748A (en)
EP (2) EP0050326B1 (en)
JP (1) JPS57122080A (en)
AU (1) AU7654781A (en)
CA (1) CA1196923A (en)
DE (1) DE3173647D1 (en)
DK (1) DK460681A (en)
ES (3) ES506228A0 (en)
FI (1) FI813246L (en)
GR (1) GR74692B (en)
IL (1) IL64080A0 (en)
NO (4) NO813526L (en)
PT (1) PT73845B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537976A (en) * 1981-04-22 1985-08-27 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
US4710876A (en) * 1985-06-05 1987-12-01 General Electric Company System and method for the display of surface structures contained within the interior region of a solid body
US5554781A (en) * 1994-03-30 1996-09-10 Reierson; Robert L. Monoalkyl phosphonic acid ester production process
ES2173182T3 (en) * 1994-04-11 2002-10-16 Chugai Pharmaceutical Co Ltd DERIVED FROM 4,6-DL-BUTIL-2,3-DIHYDROBENZOTIOPHENES AS AN LDL ANTIOXIDANTS.
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
JP3280578B2 (en) * 1996-08-30 2002-05-13 シャープ株式会社 Electrophotographic photoreceptor
IN183239B (en) * 1996-09-25 1999-10-09 Lilly Co Eli
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
US20030032779A1 (en) * 1997-06-10 2003-02-13 Lars Ohman Estrogen receptor ligands
KR20010013631A (en) * 1997-06-10 2001-02-26 오테스코그 페르 Estrogen receptor ligands
US6420391B1 (en) 1998-04-01 2002-07-16 Ono Pharmaceutical Co., Ltd. Fused thiophone derivatives and drugs containing the same as the active ingredient
US6569879B2 (en) * 2000-02-18 2003-05-27 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders
DE102007044832A1 (en) 2007-09-18 2009-04-02 Otto Bock Healthcare Ip Gmbh & Co. Kg Stand-up wheelchair
JO3805B1 (en) 2013-10-10 2021-01-31 Araxes Pharma Llc Inhibitors of kras g12c
EP3573954A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
EP3573964A1 (en) * 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophene and benzothiazole compounds and methods of use thereof
US11639346B2 (en) 2017-05-25 2023-05-02 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
BR112019024674A2 (en) 2017-05-25 2020-06-16 Araxes Pharma Llc COVALENT KRAS INHIBITORS
JP7187819B2 (en) * 2018-05-22 2022-12-13 Jnc株式会社 Liquid crystalline compound, liquid crystal composition and liquid crystal display element

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2645572A (en) 1949-12-22 1953-07-14 Univ Michigan 3-thianaphthenyloxyacetic acid, its salts and esters, and herbicidal composition thereof
ES291167A1 (en) 1962-08-28 1969-12-01 Mobil Oil Corp Procedure for preparation of benzotiofen carbamates. (Machine-translation by Google Translate, not legally binding)
US3288808A (en) 1965-01-21 1966-11-29 Mobil Oil Corp Benzothienyl carbamates
DE1300575B (en) 1965-05-21 1969-08-07 Bristol Myers Co Benzo [b] thiophenes
US3636050A (en) 1968-02-07 1972-01-18 Mobil Oil Corp N-benzothienylchloroacetamides
US3480671A (en) 1969-01-16 1969-11-25 Stauffer Chemical Co Alpha-naphthoxy acetamide compositions
US3952013A (en) * 1969-02-12 1976-04-20 Fisons Limited 1-Thiachromone-2-carboxylic acids and derivatives
CH530389A (en) 1970-03-20 1972-11-15 Ciba Geigy Ag Lipid-lowering aryloxy(thio)alkanoic acidderivs
US3836542A (en) 1971-06-07 1974-09-17 Mobil Oil Corp Derivatives of hydroxybenzo(b)thiophene
FR2221445B1 (en) * 1973-03-12 1979-04-20 Crown Zellerbach Corp
US3953601A (en) 1973-03-16 1976-04-27 Aktiebolaget Astra Dibenzothiophene derivatives as serum lipid lowering agents
DE2442829A1 (en) * 1974-09-06 1976-03-18 Merck Patent Gmbh TETRACYCLIC COMPOUNDS AND PROCEDURES FOR THEIR PRODUCTION
AU509682B2 (en) 1975-10-28 1980-05-22 Eli Lilly And Company 2-Aroyl-3-Phenylbenzothiophene Derivatives
DE2909754A1 (en) 1979-03-13 1980-09-18 Thomae Gmbh Dr K Benzofuranyl:oxy or benzothienyl:oxy substd. alkanoic acid derivs. - with hypolipidaemic activity, useful as anti-atherosclerosis agents

Also Published As

Publication number Publication date
FI813246L (en) 1982-04-21
EP0050326B1 (en) 1986-01-29
ES8301961A1 (en) 1983-01-01
NO844957L (en) 1982-04-21
EP0050326A3 (en) 1982-07-21
CA1196923A (en) 1985-11-19
NO844043L (en) 1982-04-21
GR74692B (en) 1984-08-04
ES506228A0 (en) 1983-01-01
ES8406467A1 (en) 1984-07-01
EP0155981A3 (en) 1985-10-30
NO813526L (en) 1982-04-21
DK460681A (en) 1982-04-21
EP0155981A2 (en) 1985-10-02
EP0050326A2 (en) 1982-04-28
NO844042L (en) 1982-04-21
AU7654781A (en) 1982-04-29
PT73845A (en) 1981-11-01
DE3173647D1 (en) 1986-03-13
ES524980A0 (en) 1985-02-01
IL64080A0 (en) 1982-01-31
US4436748A (en) 1984-03-13
JPS57122080A (en) 1982-07-29
PT73845B (en) 1983-06-28
ES515436A0 (en) 1984-07-01

Similar Documents

Publication Publication Date Title
ES8502987A1 (en) Benzo(b)thiophenes.
HUT42080A (en) Process for producing labdane derivatives and pharmaceutical compositions containing them
GR78987B (en)
EP0165458A3 (en) (+)-ambrox, process for production thereof and use thereof
JPS52250A (en) Process for preparation of 8-exo-hydroxy-endo-tricyclo-(5,2,2,02,6) ) unde cane
JPS52108991A (en) Purification of lactam
ES8307739A1 (en) Thiolactime ethers of delta-1-pyrrolidine, and their preparation.
JPS51138664A (en) Process for preparing 4-exo-hydroxy-endo-tri cyclo 95.2.2.02,6)-undeca-8-ene
JPS51141855A (en) Process for preparing exo-hydroxy-endo-tricyclo-(5,2,2,02,6)undecane
ES8203087A1 (en) Imidazolyl-indene-thiophenes, process for their preparation and their use as medicaments.
JPS52251A (en) Process for preparation of endo-tricyclo (5,2,2,02,6)-undecane-8-one
JPS53141261A (en) Intermediates for prostaglandins and process for their preparation
JPS51131825A (en) Process for preparation of cystindialkylester-n,n&#39;-disuccinate
JPS51127060A (en) Process for preparing 4-homoisotwistane- exo-2-ol
JPS5414961A (en) Novel 3-hydroxyazetidine-3-carboxylic derivative
JPS532476A (en) Synthesis of 4-substituted-dithio-2-azetidinone derivatives
JPS5223067A (en) Novel synthesis of 2-aminomethyl-1- ethylpyrrolidine
JPS525734A (en) Process for preparation of 5**aminoo3**5* dideoxyribostamycin
JPS5321169A (en) Novel lactone derivatives
JPS51146450A (en) Process for preparing 4-homoisotwistyl-3 -cyanide
JPS5242854A (en) Process for preparation of 2-oxyethylcyclopenta necarboxylic acid derivatives
ES8606375A1 (en) Novel 3-(4&#39;-aminobutylamino)-propylamino-bleomycin derivatives, a process for their preparation and their use as medicaments.
JPS53137933A (en) Novel cyclic sestaterpeneketones
JPS51141858A (en) Process for preparing novel 1alpha,2alpha-epoxycholest-5-ene-3-one.
JPS5318507A (en) Preparation of 2,6-dimethyl-1,3-octadiene-6-ol

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000601