ES468241A1 - Un metodo para preparar un peptido - Google Patents
Un metodo para preparar un peptidoInfo
- Publication number
- ES468241A1 ES468241A1 ES468241A ES468241A ES468241A1 ES 468241 A1 ES468241 A1 ES 468241A1 ES 468241 A ES468241 A ES 468241A ES 468241 A ES468241 A ES 468241A ES 468241 A1 ES468241 A1 ES 468241A1
- Authority
- ES
- Spain
- Prior art keywords
- phenylalanine
- group
- cysteine
- tryptophan
- threonine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 229940024606 amino acid Drugs 0.000 abstract 4
- 235000001014 amino acid Nutrition 0.000 abstract 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 2
- 239000004473 Threonine Chemical group 0.000 abstract 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- 229930182827 D-tryptophan Chemical group 0.000 abstract 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical group C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- -1 amino acid ester Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/781,580 US4105603A (en) | 1977-03-28 | 1977-03-28 | Peptides which effect release of hormones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES468241A1 true ES468241A1 (es) | 1978-12-01 |
Family
ID=25123228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES468241A Expired ES468241A1 (es) | 1977-03-28 | 1978-03-27 | Un metodo para preparar un peptido |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4105603A (enExample) |
| JP (1) | JPS53130687A (enExample) |
| AT (1) | AT366026B (enExample) |
| AU (1) | AU519122B2 (enExample) |
| BE (1) | BE865380A (enExample) |
| CA (1) | CA1102314A (enExample) |
| CH (1) | CH639361A5 (enExample) |
| DE (1) | DE2813327A1 (enExample) |
| DK (1) | DK131878A (enExample) |
| ES (1) | ES468241A1 (enExample) |
| FI (1) | FI780907A7 (enExample) |
| FR (1) | FR2385688A1 (enExample) |
| GB (1) | GB1564191A (enExample) |
| IE (1) | IE46862B1 (enExample) |
| IT (1) | IT1105152B (enExample) |
| LU (1) | LU79320A1 (enExample) |
| NL (1) | NL7803289A (enExample) |
| SE (1) | SE446190B (enExample) |
| ZA (1) | ZA781599B (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211693A (en) * | 1977-09-20 | 1980-07-08 | The Salk Institute For Biological Studies | Peptides with para-substituted phenylalanine |
| US4185010A (en) * | 1978-12-12 | 1980-01-22 | American Home Products Corporation | Nonapeptides |
| US4225472A (en) * | 1979-05-29 | 1980-09-30 | American Home Products Corporation | Truncated somatostatin analogs |
| USRE30548E (en) * | 1979-08-31 | 1981-03-17 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
| DE19375086I2 (de) * | 1979-11-27 | 2003-01-09 | Novartis Ag | Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung |
| FR2523125A1 (fr) * | 1982-03-08 | 1983-09-16 | Sanofi Sa | Analogues de la somatostatine a activite biologique modifiee et medicaments en contenant |
| US4428942A (en) | 1982-05-17 | 1984-01-31 | The Salk Institute For Biological Studies | Analogs of somatostatin |
| US4443368A (en) * | 1982-11-01 | 1984-04-17 | The Salk Institute For Biological Studies | Peptides affecting gonadal function |
| US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
| US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US4880777A (en) * | 1987-09-01 | 1989-11-14 | Eastman Kodak Company | Synthetic peptides having growth hormone releasing activity |
| AU637316B2 (en) * | 1988-01-28 | 1993-05-27 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| US6737408B1 (en) | 1997-08-07 | 2004-05-18 | University Of Cincinnati | Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm |
| EP1203014B1 (en) * | 1999-08-06 | 2004-10-13 | Genentech, Inc. | Peptide antagonists of factor viia |
| US20040001827A1 (en) * | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| EP1757311B1 (en) | 1999-12-24 | 2009-02-11 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20060228364A1 (en) * | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| US20050287153A1 (en) * | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| ES2270893T3 (es) | 1999-12-24 | 2007-04-16 | Genentech, Inc. | Procedimiento y composiciones para prolongar la vida media de compuestos bioactivos. |
| US7164002B2 (en) | 2002-02-06 | 2007-01-16 | Genentech, Inc. | FVIIa antagonists |
| CN101048425B (zh) * | 2003-09-18 | 2012-12-26 | 雷文生物技术公司 | Kid3及与其结合的kid3抗体 |
| JP4390568B2 (ja) * | 2004-01-19 | 2009-12-24 | 富士通株式会社 | 遅延測定システム |
| KR101295139B1 (ko) * | 2004-06-07 | 2013-08-12 | 레이븐 바이오테크놀로지스, 인코퍼레이티드 | 트랜스페린 리셉터 항체 |
| BRPI0516577A (pt) * | 2004-10-05 | 2008-09-16 | Genentech Inc | agentes terapêuticos com toxicidade diminuìda |
| US7687242B2 (en) * | 2005-01-12 | 2010-03-30 | Raven Biotechnologies, Inc. | KID31 and antibodies that bind thereto |
| JP2008538173A (ja) * | 2005-01-31 | 2008-10-16 | レイベン バイオテクノロジーズ，インコーポレイティド | Ｌｕｃａ２およびそれに結合する抗体 |
| WO2006084075A2 (en) | 2005-02-02 | 2006-08-10 | Raven Biotechnologies, Inc. | Adam-9 modulators |
| US20060171952A1 (en) * | 2005-02-02 | 2006-08-03 | Mather Jennie P | JAM-3 and antibodies that bind thereto |
| EP1846455A4 (en) * | 2005-02-03 | 2010-02-17 | Raven Biotechnologies Inc | ANTIBODY TO THE ONKOSTATIN M RECEPTOR |
| US20070197445A1 (en) * | 2006-01-18 | 2007-08-23 | University Of Cincinnati | Compounds for control of appetite |
| WO2008066691A2 (en) * | 2006-11-08 | 2008-06-05 | Macrogenics West, Inc. | Tes7 and antibodies that bind thereto |
| ES2414879T4 (es) | 2009-04-20 | 2013-10-30 | Allergan, Inc. | Hidrogeles de fibroína de seda y usos de éstos |
| PL219569B1 (pl) | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| ME03447B (me) | 2010-03-04 | 2020-01-20 | Macrogenics Inc | Anтitela reakтivna sa b7-нз, njihovi imunološki akтivni fragmenтi i upotreba |
| MX369220B (es) | 2011-05-21 | 2019-10-31 | Macrogenics Inc | Moleculas que enlazan cd3 capaces de enlazar a cd3 humano y no humano. |
| KR20140068087A (ko) | 2011-08-23 | 2014-06-05 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 펩티드 나노입자 및 이의 용도 |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| BR112015022790A8 (pt) | 2013-03-14 | 2020-01-21 | Univ Duke | molécula biespecífica, composição farmacêutica, método de tratamento de uma infecção por vírus latente em um indivíduo em necessidade de tal tratamento, método de tratamento de uma infecção por vírus persistente em um indivíduo em necessidade de tal tratamento, método de tratamento de uma infecção por vírus inativo em um indivíduo em necessidade de tal tratamento, método para exterminar uma célula que contém um genoma viral, e, método para exterminar uma célula que expressa uma proteína viral |
| CA2911613A1 (en) | 2013-03-29 | 2014-10-02 | Centre National De La Recherche Scientifique (Cnrs) | Cgrp receptor agonist for hiv treatment or prevention |
| WO2015184207A1 (en) | 2014-05-29 | 2015-12-03 | Macrogenics, Inc. | Tri-specific binding molecules that specifically bind to multiple cancer antigens and methods of use thereof |
| SG11201702544WA (en) | 2014-09-29 | 2017-04-27 | Univ Duke | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| RU2017129236A (ru) | 2015-01-26 | 2019-03-07 | Макродженикс, Инк. | Мультивалентные молекулы, содержащие dr5-связывающие домены |
| TWI773646B (zh) | 2015-06-08 | 2022-08-11 | 美商宏觀基因股份有限公司 | 結合lag-3的分子和其使用方法 |
| IL287916B2 (en) | 2015-07-30 | 2023-09-01 | Macrogenics Inc | Molecules that bind pd-1 and methods of using them |
| KR20250079249A (ko) | 2015-10-08 | 2025-06-04 | 마크로제닉스, 인크. | 암 치료를 위한 조합 치료법 |
| KR102815803B1 (ko) | 2015-12-02 | 2025-06-05 | 주식회사 에스티사이언스 | 당화된 btla(b- 및 t-림프구 약화인자)에 특이적인 항체 |
| SG11201804839WA (en) | 2015-12-14 | 2018-07-30 | Macrogenics Inc | Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof |
| WO2017180813A1 (en) | 2016-04-15 | 2017-10-19 | Macrogenics, Inc. | Novel b7-h3 binding molecules, antibody drug conjugates thereof and methods of use thereof |
| US10111929B1 (en) | 2017-04-07 | 2018-10-30 | Ez Ip, Llc | Growth hormone releasing factor analogs and uses |
| US20220411511A1 (en) | 2019-09-26 | 2022-12-29 | Stcube & Co. | Antibodies specific to glycosylated ctla-4 and methods of use thereof |
| KR20220088438A (ko) | 2019-10-09 | 2022-06-27 | 주식회사 에스티큐브앤컴퍼니 | 글리코실화된 lag3에 대해 특이적인 항체 및 이의 사용 방법 |
| US11596665B2 (en) | 2020-06-23 | 2023-03-07 | Chanda Zaveri | Skin lightening formulations |
| US11951203B2 (en) | 2020-08-26 | 2024-04-09 | Chanda Zaveri | Deep wrinkle vanishing compositions |
| US11793746B2 (en) | 2020-10-01 | 2023-10-24 | Chanda Zaveri | Intense skin hydration systems and methods |
| US20220110852A1 (en) | 2020-10-14 | 2022-04-14 | Chanda Zaveri | Pigment Stabilizers |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904594A (en) * | 1973-07-02 | 1975-09-09 | Salk Inst For Biological Studi | Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof |
| US3842067A (en) * | 1973-07-27 | 1974-10-15 | American Home Prod | Synthesis of(des-asn5)-srif and intermediates |
| US3917578A (en) * | 1973-12-10 | 1975-11-04 | Ayerst Mckenna & Harrison | Process for producing somatostatin and intermediates |
| US3882098A (en) * | 1974-01-03 | 1975-05-06 | American Home Prod | Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates |
| US4011207A (en) * | 1974-12-27 | 1977-03-08 | American Home Products Corporation | Des-(Ala1, Gly2,Lys4 -Srif, Des-(Ala1, Gly2, Lys4)-D-Trp8 -Srif and intermediates |
| US3933784A (en) * | 1975-01-27 | 1976-01-20 | American Home Products Corporation | Des-(ser13)-srif and intermediates |
-
1977
- 1977-03-28 US US05/781,580 patent/US4105603A/en not_active Expired - Lifetime
-
1978
- 1978-03-13 CA CA298,777A patent/CA1102314A/en not_active Expired
- 1978-03-14 IE IE511/78A patent/IE46862B1/en unknown
- 1978-03-17 GB GB10712/78A patent/GB1564191A/en not_active Expired
- 1978-03-20 ZA ZA00781599A patent/ZA781599B/xx unknown
- 1978-03-20 AU AU34307/78A patent/AU519122B2/en not_active Expired
- 1978-03-22 FI FI780907A patent/FI780907A7/fi not_active Application Discontinuation
- 1978-03-22 DK DK131878A patent/DK131878A/da not_active Application Discontinuation
- 1978-03-22 SE SE7803318A patent/SE446190B/sv not_active IP Right Cessation
- 1978-03-23 IT IT48586/78A patent/IT1105152B/it active
- 1978-03-24 AT AT0213878A patent/AT366026B/de not_active IP Right Cessation
- 1978-03-27 ES ES468241A patent/ES468241A1/es not_active Expired
- 1978-03-28 NL NL7803289A patent/NL7803289A/xx not_active Application Discontinuation
- 1978-03-28 LU LU79320A patent/LU79320A1/xx unknown
- 1978-03-28 CH CH330078A patent/CH639361A5/de not_active IP Right Cessation
- 1978-03-28 JP JP3591778A patent/JPS53130687A/ja active Granted
- 1978-03-28 BE BE186325A patent/BE865380A/xx not_active IP Right Cessation
- 1978-03-28 FR FR7808850A patent/FR2385688A1/fr active Granted
- 1978-03-28 DE DE19782813327 patent/DE2813327A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NL7803289A (nl) | 1978-10-02 |
| DK131878A (da) | 1978-09-29 |
| IE780511L (en) | 1978-09-28 |
| BE865380A (fr) | 1978-07-17 |
| GB1564191A (en) | 1980-04-02 |
| AU519122B2 (en) | 1981-11-12 |
| DE2813327C2 (enExample) | 1988-08-18 |
| ATA213878A (de) | 1981-07-15 |
| IE46862B1 (en) | 1983-10-19 |
| IT1105152B (it) | 1985-10-28 |
| SE446190B (sv) | 1986-08-18 |
| CA1102314A (en) | 1981-06-02 |
| JPS53130687A (en) | 1978-11-14 |
| CH639361A5 (de) | 1983-11-15 |
| AT366026B (de) | 1982-03-10 |
| LU79320A1 (fr) | 1978-06-29 |
| DE2813327A1 (de) | 1978-10-05 |
| ZA781599B (en) | 1979-10-31 |
| IT7848586A0 (it) | 1978-03-23 |
| SE7803318L (sv) | 1978-09-29 |
| US4105603A (en) | 1978-08-08 |
| JPS6141920B2 (enExample) | 1986-09-18 |
| AU3430778A (en) | 1979-09-27 |
| FR2385688A1 (fr) | 1978-10-27 |
| FI780907A7 (fi) | 1978-09-29 |
| FR2385688B1 (enExample) | 1983-10-07 |
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