ES461100A2 - Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina. - Google Patents
Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina.Info
- Publication number
- ES461100A2 ES461100A2 ES461100A ES461100A ES461100A2 ES 461100 A2 ES461100 A2 ES 461100A2 ES 461100 A ES461100 A ES 461100A ES 461100 A ES461100 A ES 461100A ES 461100 A2 ES461100 A2 ES 461100A2
- Authority
- ES
- Spain
- Prior art keywords
- substd
- opt
- methyl
- lower alkyl
- imidazolylmethylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Mejoras introducidas en el objeto de la patente principal nº 434.542 por procedimiento para preparar compuestos antagonistas de receptores H-2 de histamina, de fórmula 1 : **fórmula** en la que X3 y X4 , que pueden ser iguales o diferentes, son cada uno azufre, CHNO2 o NY en donde Y es hidrógeno, hidroxi, alquilo inferior, ciano o CONH, R3 y R4 que pueden ser iguales o diferentes son cada uno una agrupación de fórmula 3: Het-(CH2)mZ(CH2)n en la que Het es un anillo 2- o 4-imidazolilo opcionalmente sustituido por alquilo inferior (preferiblemente metilo), halógeno (preferiblemente cloro o bromo), trifluormetilo o hidroximetilo; un anillo 2- piridilo opcionalmente sustituido por alquilo inferior ( con preferencia metilo), halógeno (con preferencia cloro o bromo), amino, hidroxi o alcoxi inferior (con preferencia metoxi), un anillo 2-tiazolilo; un anillo 3-isotiazolilo opcionalmente sustituido por cloro o amino; Z es azufre o un grupo metileno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB3139176 | 1976-07-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES461100A2 true ES461100A2 (es) | 1978-12-01 |
Family
ID=10322405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES461100A Expired ES461100A2 (es) | 1976-07-28 | 1977-07-28 | Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina. |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS5315370A (es) |
AU (1) | AU2734677A (es) |
BE (1) | BE857218A (es) |
CA (1) | CA1070315A (es) |
DE (1) | DE2733953A1 (es) |
DK (1) | DK331877A (es) |
ES (1) | ES461100A2 (es) |
FI (1) | FI772293A (es) |
FR (1) | FR2359840A1 (es) |
IL (1) | IL52544A0 (es) |
LU (1) | LU77845A1 (es) |
NL (1) | NL7708375A (es) |
NO (1) | NO772668L (es) |
PL (1) | PL107847B1 (es) |
ZA (1) | ZA774552B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4309435A (en) | 1978-10-16 | 1982-01-05 | Imperial Chemical Industries Ltd. | Antisecretory guanidine derivatives and pharmaceutical compositions containing them |
FR2446829A1 (fr) * | 1978-11-16 | 1980-08-14 | Glaxo Group Ltd | Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant |
JPS57102852A (en) * | 1980-12-19 | 1982-06-26 | Shionogi & Co Ltd | Dicarboxylic acid diamide |
EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
-
1977
- 1977-07-18 IL IL52544A patent/IL52544A0/xx unknown
- 1977-07-22 DK DK331877A patent/DK331877A/da not_active Application Discontinuation
- 1977-07-26 LU LU77845A patent/LU77845A1/xx unknown
- 1977-07-26 AU AU27346/77A patent/AU2734677A/en active Pending
- 1977-07-27 FI FI772293A patent/FI772293A/fi not_active Application Discontinuation
- 1977-07-27 ZA ZA00774552A patent/ZA774552B/xx unknown
- 1977-07-27 NO NO772668A patent/NO772668L/no unknown
- 1977-07-27 BE BE179687A patent/BE857218A/xx unknown
- 1977-07-27 DE DE19772733953 patent/DE2733953A1/de not_active Withdrawn
- 1977-07-27 CA CA283,619A patent/CA1070315A/en not_active Expired
- 1977-07-27 FR FR7723079A patent/FR2359840A1/fr not_active Withdrawn
- 1977-07-28 JP JP9132477A patent/JPS5315370A/ja active Pending
- 1977-07-28 ES ES461100A patent/ES461100A2/es not_active Expired
- 1977-07-28 NL NL7708375A patent/NL7708375A/xx not_active Application Discontinuation
- 1977-07-28 PL PL1977199908A patent/PL107847B1/pl unknown
Also Published As
Publication number | Publication date |
---|---|
DE2733953A1 (de) | 1978-02-02 |
FR2359840A1 (fr) | 1978-02-24 |
ZA774552B (en) | 1978-06-28 |
DK331877A (da) | 1978-01-29 |
BE857218A (fr) | 1978-01-27 |
IL52544A0 (en) | 1977-10-31 |
AU2734677A (en) | 1979-02-01 |
NL7708375A (nl) | 1978-01-31 |
PL107847B1 (pl) | 1980-03-31 |
FI772293A (es) | 1978-01-29 |
LU77845A1 (es) | 1977-10-25 |
JPS5315370A (en) | 1978-02-13 |
PL199908A1 (pl) | 1978-11-20 |
NO772668L (no) | 1978-01-31 |
CA1070315A (en) | 1980-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES468985A1 (es) | Procedimiento para preparar derivados de guanidina | |
EP0254259A3 (en) | P-aminophenol derivatives | |
FI940680A0 (fi) | Menetelmä sulfamoyyli- ja amidinoryhmän sisältävien yhdisteiden valmistamiseksi | |
ES8704925A1 (es) | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno | |
NO20005881L (no) | Heterocykliske forbindelser og metoder for å behandle kardialsvikt og andre sykdommer | |
HUP0204081A2 (en) | 4-pyrimidinyl-n-acyl-l-phenylalanines, pharmaceutical compositions containing them and their use | |
CA1272482C (en) | QUINOLINECARBOXYLIC ACID DERIVATIVES | |
DK539983D0 (da) | Benzoxazolinoner og fremgangsmade til fremstilling deraf | |
KR910007883A (ko) | 퀴놀린 유도체, 그의 제조방법 및 용도 | |
ES461100A2 (es) | Procedimiento para preparar compuestos antagonistas de re- ceptores h-2 de histamina. | |
GB2001624A (en) | Guanidine derivatives | |
ES8603443A1 (es) | Procedimiento para la obtencion de derivados piperazinicos | |
TR21759A (tr) | Suebstituee edilmis fenilsuelfoniluere tuerevleri,bunlarin meydana getirilmesine mahsus usul ve herbisid olarak kullanimlari ve bunlarin meydana getirilmesine mahsus yeni ara ueruenler | |
ES405982A1 (es) | Procedimiento para la preparacion de 4-aza-bencimidazoles. | |
ATE30324T1 (de) | Piperazin-derivate von theobromin. | |
GR78961B (es) | ||
HUP9900914A2 (hu) | Simaizom sejtburjánzást gátló sztiril-benzimidazol-származékok | |
ES8604603A1 (es) | Un procedimiento para preparar derivados de 4,5,6,7-tetrahidrotiazolo (4,5-c) piridina | |
SE8602524L (sv) | Kinolinderivat | |
ES426135A1 (es) | Procedimiento de preparacion de esteres de aril-piperazino-alcanoles. | |
ATE8994T1 (de) | Piperazinderivate des theophyllins. | |
NO794279L (no) | Fremgangsmaate til fremstilling av 6,7-dimetoksy-4-amino-2-(4-(furoyl)-1-piperazinyl)-kinazolin-hydroklorid med blodtrykksenkende virkning | |
IE35505L (en) | Heterocyclic thiourea derivatives. | |
ES421767A2 (es) | Un procedimiento para la preparacion de acidos 5-sulfamil- benzoicos sustituidos en la posicion 2. | |
JO1274B1 (en) | Pyridine derivatives |