GB2001624A - Guanidine derivatives - Google Patents

Guanidine derivatives

Info

Publication number
GB2001624A
GB2001624A GB7827634A GB7827634A GB2001624A GB 2001624 A GB2001624 A GB 2001624A GB 7827634 A GB7827634 A GB 7827634A GB 7827634 A GB7827634 A GB 7827634A GB 2001624 A GB2001624 A GB 2001624A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
image
guanidine derivatives
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7827634A
Other versions
GB2001624B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Zeneca Inc
Original Assignee
Imperial Chemical Industries Ltd
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd, ICI Americas Inc filed Critical Imperial Chemical Industries Ltd
Priority to GB7827634A priority Critical patent/GB2001624B/en
Publication of GB2001624A publication Critical patent/GB2001624A/en
Application granted granted Critical
Publication of GB2001624B publication Critical patent/GB2001624B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Histamine H-2 antagonists which inhibit the secretion of gastric acid, are of the general formula I:- <IMAGE> in which X is S or NH, Y is O, S, SO, CH2, a direct bond or a vinylene radical, m is 0 to 4 and n is 1 to 4, R<1> is hydrogen, halogen or alkyl, R<2> is hydrogen, alkyl, alkanoyl or aroyl, A is a 3,4-dioxocyclobuten- -1,2-diyl radical or C = Z in which Z is O, S NCN, NNO2, CHNO2, NCONH2, C(CN)2, NCOR<3>, NCO2R<3>, NSO2R<3> or NR<4> in which R<3> is alkyl or aryl and R<4> is hydrogen or alkyl, B is alkoxy or alkylthio or NR<5>R<6> in which R<5> and R<6> are independently hydrogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl or dialkylaminoalkyl; and the salts thereof. <IMAGE>
GB7827634A 1977-04-20 1978-06-22 Guanidine derivatives processes for their manufacture and pharmaceutical compositions containing them Expired GB2001624B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7827634A GB2001624B (en) 1977-04-20 1978-06-22 Guanidine derivatives processes for their manufacture and pharmaceutical compositions containing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1638977 1977-04-20
GB7827634A GB2001624B (en) 1977-04-20 1978-06-22 Guanidine derivatives processes for their manufacture and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
GB2001624A true GB2001624A (en) 1979-02-07
GB2001624B GB2001624B (en) 1982-03-03

Family

ID=26252012

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7827634A Expired GB2001624B (en) 1977-04-20 1978-06-22 Guanidine derivatives processes for their manufacture and pharmaceutical compositions containing them

Country Status (1)

Country Link
GB (1) GB2001624B (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010894A1 (en) * 1978-10-16 1980-05-14 Imperial Chemical Industries Plc Antisecretory heterocyclic guanidine derivatives, process for their manufacture and pharmaceutical compositions containing them
EP0028117A1 (en) * 1979-10-24 1981-05-06 Smith Kline & French Laboratories Limited Guanidine compounds, process for preparing them and compositions containing them
EP0028482A1 (en) * 1979-10-24 1981-05-13 Smith Kline & French Laboratories Limited Guanidine compounds, process for preparing them and compositions containing them
EP0030092A1 (en) * 1979-11-13 1981-06-10 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
EP0045155A1 (en) * 1980-07-30 1982-02-03 Imperial Chemical Industries Plc Guanidine derivatives
EP0060697A1 (en) * 1981-03-18 1982-09-22 Imperial Chemical Industries Plc Heterocyclic derivatives
EP0060696A1 (en) * 1981-03-13 1982-09-22 Imperial Chemical Industries Plc Nitrogen heterocycles
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
EP0102026A2 (en) * 1982-08-20 1984-03-07 Hoechst Uk Limited Thiazole derivatives
GB2131796A (en) * 1982-12-03 1984-06-27 Kotobuki Seiyaku Co Ltd Thiazole derivatives
US4539316A (en) * 1981-05-18 1985-09-03 Bristol-Myers Company Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
EP0156286A2 (en) * 1984-03-27 1985-10-02 Hoechst Uk Limited Thiatrizine derivatives
US4546188A (en) * 1981-05-18 1985-10-08 Bristol-Myers Company Substituted 1,2-diaminocyclobutene-3,4-diones
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395553A (en) 1981-05-18 1983-07-26 Bristol-Myers Company Chemical compounds
US4390701A (en) 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010894A1 (en) * 1978-10-16 1980-05-14 Imperial Chemical Industries Plc Antisecretory heterocyclic guanidine derivatives, process for their manufacture and pharmaceutical compositions containing them
EP0028117A1 (en) * 1979-10-24 1981-05-06 Smith Kline & French Laboratories Limited Guanidine compounds, process for preparing them and compositions containing them
EP0028482A1 (en) * 1979-10-24 1981-05-13 Smith Kline & French Laboratories Limited Guanidine compounds, process for preparing them and compositions containing them
EP0028117B1 (en) * 1979-10-24 1983-12-28 Smith Kline & French Laboratories Limited Guanidine compounds, process for preparing them and compositions containing them
EP0030092A1 (en) * 1979-11-13 1981-06-10 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
EP0045155A1 (en) * 1980-07-30 1982-02-03 Imperial Chemical Industries Plc Guanidine derivatives
EP0060696A1 (en) * 1981-03-13 1982-09-22 Imperial Chemical Industries Plc Nitrogen heterocycles
EP0060697A1 (en) * 1981-03-18 1982-09-22 Imperial Chemical Industries Plc Heterocyclic derivatives
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
US4539316A (en) * 1981-05-18 1985-09-03 Bristol-Myers Company Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
US4546188A (en) * 1981-05-18 1985-10-08 Bristol-Myers Company Substituted 1,2-diaminocyclobutene-3,4-diones
EP0102026A2 (en) * 1982-08-20 1984-03-07 Hoechst Uk Limited Thiazole derivatives
EP0102026A3 (en) * 1982-08-20 1984-05-16 Hoechst Uk Limited Thiazole derivatives
US4649145A (en) * 1982-08-20 1987-03-10 Hoechst Uk Limited Thiazole derivatives
GB2131796A (en) * 1982-12-03 1984-06-27 Kotobuki Seiyaku Co Ltd Thiazole derivatives
EP0156286A2 (en) * 1984-03-27 1985-10-02 Hoechst Uk Limited Thiatrizine derivatives
EP0156286A3 (en) * 1984-03-27 1986-08-20 Hoechst Uk Limited Thiatrizine derivatives
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Also Published As

Publication number Publication date
GB2001624B (en) 1982-03-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940622