IT1127215B - N-substd. 2-anilino-2-imidazoline derivs. - Google Patents

N-substd. 2-anilino-2-imidazoline derivs.

Info

Publication number
IT1127215B
IT1127215B IT27202/79A IT2720279A IT1127215B IT 1127215 B IT1127215 B IT 1127215B IT 27202/79 A IT27202/79 A IT 27202/79A IT 2720279 A IT2720279 A IT 2720279A IT 1127215 B IT1127215 B IT 1127215B
Authority
IT
Italy
Prior art keywords
imidazoline
substd
anilino
activity
derivs
Prior art date
Application number
IT27202/79A
Other languages
Italian (it)
Other versions
IT7927202A0 (en
Inventor
Elso Manghisi
Giuseppe Cascio
Giancarlo B Fregnan
Giovanni Ferni
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Publication of IT7927202A0 publication Critical patent/IT7927202A0/en
Priority to IT27202/79A priority Critical patent/IT1127215B/en
Priority to FI793727A priority patent/FI65428C/en
Priority to CH1061279A priority patent/CH645358A5/en
Priority to AU53283/79A priority patent/AU517623B2/en
Priority to CA000340891A priority patent/CA1137090A/en
Priority to DK512479A priority patent/DK159317C/en
Priority to GB7941802A priority patent/GB2041355B/en
Priority to US06/100,833 priority patent/US4262006A/en
Priority to NLAANVRAGE7908853,A priority patent/NL183139C/en
Priority to SE7910157A priority patent/SE430503B/en
Priority to NO794047A priority patent/NO152171C/en
Priority to FR7930361A priority patent/FR2444036A1/en
Priority to ES487167A priority patent/ES487167A0/en
Priority to PT70584A priority patent/PT70584A/en
Priority to DE2949971A priority patent/DE2949971C2/en
Application granted granted Critical
Publication of IT1127215B publication Critical patent/IT1127215B/en

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Abstract

Imidazoline derivs of formula (I) and their salts are new: (where R is tetrayhydro-2-furyl or tetrahydro-2-pyranyl; R1 and R2 are H, F, Cl, Br or 1-4C alkyl). Cpds (I) have hypotensive bradycardiac and diuretic activity with better therapeutic characteristics than the corresp cpds where R=H. e.g. 2- N-(2,6-dichlorophenyl)-N-(tetrahydro-2-pyranyl) amino -2-imidazoline (Ia) has higher and longer-lasting hypotensive activity than clonidine, and lower sedative activity.
IT27202/79A 1978-12-12 1979-11-12 N-substd. 2-anilino-2-imidazoline derivs. IT1127215B (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT27202/79A IT1127215B (en) 1979-11-12 1979-11-12 N-substd. 2-anilino-2-imidazoline derivs.
FI793727A FI65428C (en) 1978-12-12 1979-11-28 DERIVATIVES FOR THE FRAMEWORK OF PHARMACOLOGICAL PROPERTIES OF 2-PHENYLAMINO-IMIDAZOLE (2)
CH1061279A CH645358A5 (en) 1978-12-12 1979-11-29 2-FENILAMINO-IMIDAZOLINE- (2) REPLACED, WITH PARTICULAR THERAPEUTIC PROPERTIES, THEIR PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS.
AU53283/79A AU517623B2 (en) 1978-12-12 1979-11-29 Substituted 2-phenyl-imidazolines-(2)
CA000340891A CA1137090A (en) 1978-12-12 1979-11-29 Substituted 2-phenylamino-imidazolines-(2), having particular therapeutic properties, process for their preparation, and pharmaceutical compositions containing them
DK512479A DK159317C (en) 1978-12-12 1979-12-03 METHOD OF ANALOGUE FOR PREPARING SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2) DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
GB7941802A GB2041355B (en) 1978-12-12 1979-12-04 Substituted 2-phenyl-aminoimidazol-2-ines process for their preparation and phamraceutical compositions containing them
US06/100,833 US4262006A (en) 1978-12-12 1979-12-06 Substituted 2-phenylamino-imidazolines-(2) and pharmaceutical compositions containing them
NLAANVRAGE7908853,A NL183139C (en) 1978-12-12 1979-12-07 SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINES, METHOD FOR PREPARING THE SAME AND MEDICINAL PREPARATIONS.
SE7910157A SE430503B (en) 1978-12-12 1979-12-10 SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE (2) -S WITH SPECIAL THERAPUTICAL PROPERTIES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO794047A NO152171C (en) 1978-12-12 1979-12-11 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE IMIDAZOLINE DERIVATIVES
FR7930361A FR2444036A1 (en) 1978-12-12 1979-12-11 2-PHENYLAMINO-IMIDAZOLINES- (2) SUBSTITUTED, WITH SPECIAL THERAPEUTIC PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
ES487167A ES487167A0 (en) 1978-12-12 1979-12-11 PROCEDURE FOR THE OBTAINING OF 2-PHENYLAMINE-IMIDAZOLINES- (2) SUBSTITUTED
PT70584A PT70584A (en) 1978-12-12 1979-12-12 Process of synthesis for the preparation of substituted 2-phenylamino-imidazoline-(2)with particular pharmaceutical properties
DE2949971A DE2949971C2 (en) 1978-12-12 1979-12-12 2-Phenylamino-2-imidazoline derivatives with special therapeutic properties, processes for their preparation and pharmaceuticals containing these compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT27202/79A IT1127215B (en) 1979-11-12 1979-11-12 N-substd. 2-anilino-2-imidazoline derivs.

Publications (2)

Publication Number Publication Date
IT7927202A0 IT7927202A0 (en) 1979-11-12
IT1127215B true IT1127215B (en) 1986-05-21

Family

ID=11221172

Family Applications (1)

Application Number Title Priority Date Filing Date
IT27202/79A IT1127215B (en) 1978-12-12 1979-11-12 N-substd. 2-anilino-2-imidazoline derivs.

Country Status (1)

Country Link
IT (1) IT1127215B (en)

Also Published As

Publication number Publication date
IT7927202A0 (en) 1979-11-12

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