IT1127215B - N-substd. 2-anilino-2-imidazoline derivs. - Google Patents
N-substd. 2-anilino-2-imidazoline derivs.Info
- Publication number
- IT1127215B IT1127215B IT27202/79A IT2720279A IT1127215B IT 1127215 B IT1127215 B IT 1127215B IT 27202/79 A IT27202/79 A IT 27202/79A IT 2720279 A IT2720279 A IT 2720279A IT 1127215 B IT1127215 B IT 1127215B
- Authority
- IT
- Italy
- Prior art keywords
- imidazoline
- substd
- anilino
- activity
- derivs
- Prior art date
Links
- JCOPITWIWLFFPC-UHFFFAOYSA-N n-phenyl-4,5-dihydro-1h-imidazol-2-amine Chemical compound N1CCN=C1NC1=CC=CC=C1 JCOPITWIWLFFPC-UHFFFAOYSA-N 0.000 title 1
- 230000001077 hypotensive effect Effects 0.000 abstract 2
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000059 bradycardiac effect Effects 0.000 abstract 1
- 229960002896 clonidine Drugs 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- -1 tetrahydro-2-pyranyl Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Imidazoline derivs of formula (I) and their salts are new: (where R is tetrayhydro-2-furyl or tetrahydro-2-pyranyl; R1 and R2 are H, F, Cl, Br or 1-4C alkyl). Cpds (I) have hypotensive bradycardiac and diuretic activity with better therapeutic characteristics than the corresp cpds where R=H. e.g. 2- N-(2,6-dichlorophenyl)-N-(tetrahydro-2-pyranyl) amino -2-imidazoline (Ia) has higher and longer-lasting hypotensive activity than clonidine, and lower sedative activity.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT27202/79A IT1127215B (en) | 1979-11-12 | 1979-11-12 | N-substd. 2-anilino-2-imidazoline derivs. |
FI793727A FI65428C (en) | 1978-12-12 | 1979-11-28 | DERIVATIVES FOR THE FRAMEWORK OF PHARMACOLOGICAL PROPERTIES OF 2-PHENYLAMINO-IMIDAZOLE (2) |
CH1061279A CH645358A5 (en) | 1978-12-12 | 1979-11-29 | 2-FENILAMINO-IMIDAZOLINE- (2) REPLACED, WITH PARTICULAR THERAPEUTIC PROPERTIES, THEIR PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS. |
AU53283/79A AU517623B2 (en) | 1978-12-12 | 1979-11-29 | Substituted 2-phenyl-imidazolines-(2) |
CA000340891A CA1137090A (en) | 1978-12-12 | 1979-11-29 | Substituted 2-phenylamino-imidazolines-(2), having particular therapeutic properties, process for their preparation, and pharmaceutical compositions containing them |
DK512479A DK159317C (en) | 1978-12-12 | 1979-12-03 | METHOD OF ANALOGUE FOR PREPARING SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINE (2) DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS. |
GB7941802A GB2041355B (en) | 1978-12-12 | 1979-12-04 | Substituted 2-phenyl-aminoimidazol-2-ines process for their preparation and phamraceutical compositions containing them |
US06/100,833 US4262006A (en) | 1978-12-12 | 1979-12-06 | Substituted 2-phenylamino-imidazolines-(2) and pharmaceutical compositions containing them |
NLAANVRAGE7908853,A NL183139C (en) | 1978-12-12 | 1979-12-07 | SUBSTITUTED 2-PHENYLAMINO-IMIDAZOLINES, METHOD FOR PREPARING THE SAME AND MEDICINAL PREPARATIONS. |
SE7910157A SE430503B (en) | 1978-12-12 | 1979-12-10 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE (2) -S WITH SPECIAL THERAPUTICAL PROPERTIES, PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
NO794047A NO152171C (en) | 1978-12-12 | 1979-12-11 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE IMIDAZOLINE DERIVATIVES |
FR7930361A FR2444036A1 (en) | 1978-12-12 | 1979-12-11 | 2-PHENYLAMINO-IMIDAZOLINES- (2) SUBSTITUTED, WITH SPECIAL THERAPEUTIC PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
ES487167A ES487167A0 (en) | 1978-12-12 | 1979-12-11 | PROCEDURE FOR THE OBTAINING OF 2-PHENYLAMINE-IMIDAZOLINES- (2) SUBSTITUTED |
PT70584A PT70584A (en) | 1978-12-12 | 1979-12-12 | Process of synthesis for the preparation of substituted 2-phenylamino-imidazoline-(2)with particular pharmaceutical properties |
DE2949971A DE2949971C2 (en) | 1978-12-12 | 1979-12-12 | 2-Phenylamino-2-imidazoline derivatives with special therapeutic properties, processes for their preparation and pharmaceuticals containing these compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT27202/79A IT1127215B (en) | 1979-11-12 | 1979-11-12 | N-substd. 2-anilino-2-imidazoline derivs. |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7927202A0 IT7927202A0 (en) | 1979-11-12 |
IT1127215B true IT1127215B (en) | 1986-05-21 |
Family
ID=11221172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT27202/79A IT1127215B (en) | 1978-12-12 | 1979-11-12 | N-substd. 2-anilino-2-imidazoline derivs. |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1127215B (en) |
-
1979
- 1979-11-12 IT IT27202/79A patent/IT1127215B/en active
Also Published As
Publication number | Publication date |
---|---|
IT7927202A0 (en) | 1979-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH22490A (en) | Paf-antagonistic diazepines | |
DE3585980D1 (en) | HYDRAZINE DERIVATIVES AND THEIR USE. | |
DE69121706D1 (en) | O6-BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS WITH O6-ALKYLGUANIN-DNA-ALKYLTRANSFERASE DECIMALED ACTIVITY | |
JPS6422813A (en) | Antiphlegmonic slimming cosmetics containing 1-hydroxyalkylxanthin | |
GR852026B (en) | ||
ES8506652A1 (en) | Dibenzodiazepin derivatives, a process for their preparation and their use as medicaments. | |
IT1127215B (en) | N-substd. 2-anilino-2-imidazoline derivs. | |
DE3060153D1 (en) | Derivatives of substituted 2-benzoyl glycinanilides, their preparation and their use in anxiolytic medicaments | |
ES8602352A1 (en) | Derivatives of 2-alkoxyaminosulfonylbenzenesulfonylurea. | |
ES464483A1 (en) | Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones | |
MY103572A (en) | 3,4-dihydro-2-alkyl-3-oxo-n-aryl-2h-[1] benzothieno [3,2-e]-1,2-thiazine-4-carboxamide-1, 1-dioxides. | |
ZA815910B (en) | N-sulphenylated ureas,a process for their preparation,fungicidal agents containing them and their use | |
GB1556877A (en) | Imidazothiazoles and thiazolopyrimidines | |
GR77967B (en) | ||
ATE23861T1 (en) | SUBSTITUTED BENZOXAZINE DERIVATIVES. | |
ES8106147A1 (en) | 1,2,4-Triazole-3-thiols as antisecretory agents | |
SU1181283A1 (en) | DIHYDROCHLORIDA 2-PHENYL-4-β-DIALKYLAMINOETHILPYRAZOLO / 1,5-a / BENZIMIDAZOLES, possessing antiarrhythmic and hypotensive activity | |
JPS5283533A (en) | 6-substituted naphtehalene-2-oxyalkylamines | |
IT1158736B (en) | Antihypertensive pyrrolo-imidazole derivs - viz. 6-aryl-2,3,6,7-tetrahydro-5H-pyrrolo(1,2-a) imidazoles (BE300776) | |
SU1624959A1 (en) | 5- (β-P-METOXYPHENYL-β-OXIETHYL) -2-METHYLTIO-1-Meths-4,5,6,7-TETRAHYDROI MIDAZO [4,5-C] PYRIDINE DIHYDROCHLORIDE OWNING HYPOTENGEN, ANTIHYPE'PIPPERS, ANTIGIPPERS, NGPERS, ANTI-CIPPERS, ANTI-CHYTHROCHLORIDE, HYPOTENGEN, AND ANTI-CIPERS ACTION | |
PT64748A (en) | Heterocyclic compounds | |
FR2446824A1 (en) | 4,5,6,7-TETRAHYDRO-1H (OR 2H) -INDAZOLES WITH AMINO GROUP AND THEIR THERAPEUTIC USE | |
FR2333510A2 (en) | 1-Aroylethyl 2-piperazinomethyl benzimidazoles - useful eg for treatment of ulcers, asthma, hypertension, oedemand pain | |
DE3777999D1 (en) | SUBSTITUTED PIPERIDINE OR AZEPINE, THEIR PRODUCTION AND THERAPEUTIC USE. | |
FR2035783A1 (en) | (A) Cpds. of formula I and their therapeutically active acid addition salts: where n=4 or 5 z=1, 2 or 3 (aryl=Ph, R=R1=H, n=4 when z=3), R=H or lowe |