ES460132A1 - Production of cephalosporin derivative - Google Patents

Production of cephalosporin derivative

Info

Publication number
ES460132A1
ES460132A1 ES460132A ES460132A ES460132A1 ES 460132 A1 ES460132 A1 ES 460132A1 ES 460132 A ES460132 A ES 460132A ES 460132 A ES460132 A ES 460132A ES 460132 A1 ES460132 A1 ES 460132A1
Authority
ES
Spain
Prior art keywords
iii
cnch2
give
formula
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES460132A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Publication of ES460132A1 publication Critical patent/ES460132A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/28—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms

Abstract

Cephalosporins of formula (I) comprises reacting 7-amino cpds. of formula (II) wiht acylating agents CNCH2. CO.O.Q (III). (M is H,Na,K, NH4, tri(lower alkyl)amino or trimethylsilyl Q is CNCH2CO or SO2R R is CH3, C2H5, C3H7, C6H5, ptolyl, OLi, ONa or OK). Pref. reaction is in an inert solvent at -20 to 0 degrees C. (I) are antibiotics suitable for intramuscular application. (III) react to give (I) only, unlike mixed anhydrides with other carboxylic acids which give mixts. from which it is difficult to separate (I). (III) can be prepared in situ. In an example, Na cephacetril was prepd. by reacting 7-ACA with CNCH2. CO.O.SO2CH3, then adding Na acetate.
ES460132A 1976-07-10 1977-06-27 Production of cephalosporin derivative Expired ES460132A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2880576 1976-07-10

Publications (1)

Publication Number Publication Date
ES460132A1 true ES460132A1 (en) 1978-05-01

Family

ID=10281470

Family Applications (1)

Application Number Title Priority Date Filing Date
ES460132A Expired ES460132A1 (en) 1976-07-10 1977-06-27 Production of cephalosporin derivative

Country Status (5)

Country Link
JP (1) JPS5323992A (en)
DE (1) DE2730580A1 (en)
ES (1) ES460132A1 (en)
FR (1) FR2357568A1 (en)
NL (1) NL7707679A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10284762A (en) 1995-02-16 1998-10-23 Asahi Chem Ind Co Ltd Laminated structure for amplifying surface acoustic wave and amplifier

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988326A (en) * 1974-02-22 1976-10-26 Meiji Seika Kaisha, Ltd. Process for N-acylation of 7 amino cephem compounds

Also Published As

Publication number Publication date
FR2357568A1 (en) 1978-02-03
DE2730580A1 (en) 1978-01-12
JPS5323992A (en) 1978-03-06
NL7707679A (en) 1978-01-12

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