ES460080A1 - Un procedimiento para la preparacion de carboestirilos bici-clicos y triciclicos. - Google Patents
Un procedimiento para la preparacion de carboestirilos bici-clicos y triciclicos.Info
- Publication number
- ES460080A1 ES460080A1 ES460080A ES460080A ES460080A1 ES 460080 A1 ES460080 A1 ES 460080A1 ES 460080 A ES460080 A ES 460080A ES 460080 A ES460080 A ES 460080A ES 460080 A1 ES460080 A1 ES 460080A1
- Authority
- ES
- Spain
- Prior art keywords
- blocker
- action
- antihypertensive agents
- side effects
- carbstirilos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940030600 antihypertensive agent Drugs 0.000 abstract 3
- 239000002220 antihypertensive agent Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000010534 mechanism of action Effects 0.000 abstract 2
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 abstract 1
- SSSYOIPHXANRMO-UHFFFAOYSA-N 4h-benzo[a]quinolizine Chemical class C1=CC=C2C3=CC=CCN3C=CC2=C1 SSSYOIPHXANRMO-UHFFFAOYSA-N 0.000 abstract 1
- QZVCTJOXCFMACW-UHFFFAOYSA-N Phenoxybenzamine Chemical compound C=1C=CC=CC=1CN(CCCl)C(C)COC1=CC=CC=C1 QZVCTJOXCFMACW-UHFFFAOYSA-N 0.000 abstract 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 abstract 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 abstract 1
- 210000002934 adrenergic neuron Anatomy 0.000 abstract 1
- 102000004305 alpha Adrenergic Receptors Human genes 0.000 abstract 1
- 108090000861 alpha Adrenergic Receptors Proteins 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000000609 ganglia Anatomy 0.000 abstract 1
- IMYZQPCYWPFTAG-IQJOONFLSA-N mecamylamine Chemical compound C1C[C@@H]2C(C)(C)[C@@](NC)(C)[C@H]1C2 IMYZQPCYWPFTAG-IQJOONFLSA-N 0.000 abstract 1
- 229960002525 mecamylamine Drugs 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 229960003418 phenoxybenzamine Drugs 0.000 abstract 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 abstract 1
- 229960003147 reserpine Drugs 0.000 abstract 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69958876A | 1976-06-24 | 1976-06-24 | |
| US69958776A | 1976-06-24 | 1976-06-24 | |
| US79371177A | 1977-05-06 | 1977-05-06 | |
| US79371277A | 1977-05-06 | 1977-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES460080A1 true ES460080A1 (es) | 1978-10-01 |
Family
ID=27505478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES460080A Expired ES460080A1 (es) | 1976-06-24 | 1977-06-23 | Un procedimiento para la preparacion de carboestirilos bici-clicos y triciclicos. |
Country Status (17)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251659A (en) * | 1977-12-22 | 1981-02-17 | E. I. Du Pont De Nemours And Company | Polyfluorohydroxyisopropyl-heterocyclic compounds |
| US4251534A (en) * | 1977-12-22 | 1981-02-17 | E. I. Du Pont De Nemours And Company | Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils |
| ZA786261B (en) * | 1977-12-22 | 1979-10-31 | Du Pont | Carbostyrils |
| US4322417A (en) * | 1977-12-22 | 1982-03-30 | E. I. Du Pont De Nemours And Company | Antihypertensive polyfluoroisopropyl tricyclic carbostyrils |
| AU2005238176B2 (en) | 2004-05-03 | 2008-11-27 | F. Hoffmann-La Roche Ag | Indolyl derivatives as liver-X-receptor modulators |
| EP3201266B1 (en) * | 2014-10-01 | 2019-12-11 | Henkel IP & Holding GmbH | Cure accelerators for anaerobic curable compositions |
-
1977
- 1977-06-20 IE IE1250/77A patent/IE45227B1/en unknown
- 1977-06-20 GR GR53749A patent/GR63361B/el unknown
- 1977-06-22 AR AR268155A patent/AR224334A1/es active
- 1977-06-22 NZ NZ184458A patent/NZ184458A/xx unknown
- 1977-06-22 DE DE19772728029 patent/DE2728029A1/de not_active Withdrawn
- 1977-06-23 BE BE178704A patent/BE856024A/xx unknown
- 1977-06-23 NO NO772230A patent/NO772230L/no unknown
- 1977-06-23 ES ES460080A patent/ES460080A1/es not_active Expired
- 1977-06-23 GB GB26355/77A patent/GB1583249A/en not_active Expired
- 1977-06-23 SE SE7707303A patent/SE7707303L/xx not_active Application Discontinuation
- 1977-06-23 FI FI771977A patent/FI771977A7/fi not_active Application Discontinuation
- 1977-06-23 FR FR7719247A patent/FR2355828A1/fr not_active Withdrawn
- 1977-06-23 DK DK279777A patent/DK279777A/da unknown
- 1977-06-23 IL IL52378A patent/IL52378A/xx unknown
- 1977-06-24 NL NL7707062A patent/NL7707062A/xx not_active Application Discontinuation
- 1977-06-24 JP JP7603677A patent/JPS5323983A/ja active Pending
- 1977-06-24 LU LU77609A patent/LU77609A1/xx unknown
-
1978
- 1978-03-17 FR FR7807798A patent/FR2372809A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NL7707062A (nl) | 1977-12-28 |
| DE2728029A1 (de) | 1978-01-05 |
| SE7707303L (sv) | 1977-12-25 |
| GR63361B (en) | 1979-10-22 |
| FR2372809A1 (fr) | 1978-06-30 |
| IE45227L (en) | 1977-12-24 |
| IL52378A (en) | 1981-01-30 |
| GB1583249A (en) | 1981-01-21 |
| IE45227B1 (en) | 1982-07-14 |
| DK279777A (da) | 1977-12-25 |
| FI771977A7 (enrdf_load_html_response) | 1977-12-25 |
| FR2355828A1 (fr) | 1978-01-20 |
| JPS5323983A (en) | 1978-03-06 |
| AR224334A1 (es) | 1981-11-30 |
| LU77609A1 (enrdf_load_html_response) | 1978-02-01 |
| NZ184458A (en) | 1979-12-11 |
| IL52378A0 (en) | 1977-08-31 |
| FR2372809B1 (enrdf_load_html_response) | 1981-07-24 |
| BE856024A (fr) | 1977-12-23 |
| NO772230L (no) | 1977-12-28 |
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