ES460080A1 - Carbostyrils - Google Patents

Carbostyrils

Info

Publication number
ES460080A1
ES460080A1 ES460080A ES460080A ES460080A1 ES 460080 A1 ES460080 A1 ES 460080A1 ES 460080 A ES460080 A ES 460080A ES 460080 A ES460080 A ES 460080A ES 460080 A1 ES460080 A1 ES 460080A1
Authority
ES
Spain
Prior art keywords
blocker
action
antihypertensive agents
side effects
adrenergic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES460080A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES460080A1 publication Critical patent/ES460080A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Benzoquinolizines are described as antihypertensive agents; the following compound is illustrative: ** (formula) ** many current antihypertensive agents produce undesirable side effects due to their mechanism of action. For example, guanitidine is a blocker of the adrenergic neuron, mecamylamine is a blocker of the ganglia, phenoxybenzamine is a blocker of alpha-adrenergic receptors, and reserpine is a catercholamine-depleting agent. All these mechanisms of action are undesirable due to the serious side effects produced. The compounds of this invention reduce blood pressure by a suitable mechanism of action, namely, direct peripheral vasophyllisation and, therefore, have clear advantages over the above-mentioned undesired antihypertensive agents. (Machine-translation by Google Translate, not legally binding)
ES460080A 1976-06-24 1977-06-23 Carbostyrils Expired ES460080A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69958776A 1976-06-24 1976-06-24
US69958876A 1976-06-24 1976-06-24
US79371277A 1977-05-06 1977-05-06
US79371177A 1977-05-06 1977-05-06

Publications (1)

Publication Number Publication Date
ES460080A1 true ES460080A1 (en) 1978-10-01

Family

ID=27505478

Family Applications (1)

Application Number Title Priority Date Filing Date
ES460080A Expired ES460080A1 (en) 1976-06-24 1977-06-23 Carbostyrils

Country Status (17)

Country Link
JP (1) JPS5323983A (en)
AR (1) AR224334A1 (en)
BE (1) BE856024A (en)
DE (1) DE2728029A1 (en)
DK (1) DK279777A (en)
ES (1) ES460080A1 (en)
FI (1) FI771977A (en)
FR (2) FR2355828A1 (en)
GB (1) GB1583249A (en)
GR (1) GR63361B (en)
IE (1) IE45227B1 (en)
IL (1) IL52378A (en)
LU (1) LU77609A1 (en)
NL (1) NL7707062A (en)
NO (1) NO772230L (en)
NZ (1) NZ184458A (en)
SE (1) SE7707303L (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251659A (en) * 1977-12-22 1981-02-17 E. I. Du Pont De Nemours And Company Polyfluorohydroxyisopropyl-heterocyclic compounds
US4322417A (en) * 1977-12-22 1982-03-30 E. I. Du Pont De Nemours And Company Antihypertensive polyfluoroisopropyl tricyclic carbostyrils
US4251534A (en) * 1977-12-22 1981-02-17 E. I. Du Pont De Nemours And Company Antihypertensive polyfluorohydroxyisopropyl bicyclic and tricyclic carbostyrils
ZA786261B (en) * 1977-12-22 1979-10-31 Du Pont Carbostyrils
RU2368612C2 (en) * 2004-05-03 2009-09-27 Ф.Хоффманн-Ля Рош Аг Indolyl derivatives as liver x-receptor modulators
MX2017003786A (en) * 2014-10-01 2017-06-28 Henkel IP & Holding GmbH Cure accelerators for anaerobic curable compositions.

Also Published As

Publication number Publication date
FR2372809A1 (en) 1978-06-30
IE45227B1 (en) 1982-07-14
IE45227L (en) 1977-12-24
JPS5323983A (en) 1978-03-06
NL7707062A (en) 1977-12-28
NZ184458A (en) 1979-12-11
GR63361B (en) 1979-10-22
FI771977A (en) 1977-12-25
DK279777A (en) 1977-12-25
FR2372809B1 (en) 1981-07-24
SE7707303L (en) 1977-12-25
BE856024A (en) 1977-12-23
GB1583249A (en) 1981-01-21
FR2355828A1 (en) 1978-01-20
IL52378A (en) 1981-01-30
AR224334A1 (en) 1981-11-30
NO772230L (en) 1977-12-28
DE2728029A1 (en) 1978-01-05
LU77609A1 (en) 1978-02-01
IL52378A0 (en) 1977-08-31

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