ES451701A1 - Procedimiento para la obtencion de y-lactonas de acidos 6 beta, 17-dihidroxi-7 alfa-(alcoxi inferior) -carbonil-3-oxo-17 alfa'pregn-4-eno-21-carboxilicos. - Google Patents

Procedimiento para la obtencion de y-lactonas de acidos 6 beta, 17-dihidroxi-7 alfa-(alcoxi inferior) -carbonil-3-oxo-17 alfa'pregn-4-eno-21-carboxilicos.

Info

Publication number
ES451701A1
ES451701A1 ES451701A ES451701A ES451701A1 ES 451701 A1 ES451701 A1 ES 451701A1 ES 451701 A ES451701 A ES 451701A ES 451701 A ES451701 A ES 451701A ES 451701 A1 ES451701 A1 ES 451701A1
Authority
ES
Spain
Prior art keywords
pregn
lactones
ene
dihydroxy
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES451701A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES451701A1 publication Critical patent/ES451701A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Abstract

Procedimiento para la obtención de gamma-lactonas de ácidos 6beta,17-dihidroxi-7alfa-(alcoxi inferior)carbonil-3-oxo-17alfa-pregn-4-eno-21-carboxílicos, caracterizado porque comprende, en una primea etapa, oxidar un compuesto de fórmula general: **(Fórmula)** en la que R es un radical alquilo con 1 a 7 átomos de carbono, con un peroxiácido adecuado en presencia de un disolvente orgánico acuoso.
ES451701A 1975-09-22 1976-09-21 Procedimiento para la obtencion de y-lactonas de acidos 6 beta, 17-dihidroxi-7 alfa-(alcoxi inferior) -carbonil-3-oxo-17 alfa'pregn-4-eno-21-carboxilicos. Expired ES451701A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/615,412 US3972871A (en) 1975-09-22 1975-09-22 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Publications (1)

Publication Number Publication Date
ES451701A1 true ES451701A1 (es) 1978-01-01

Family

ID=24465262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES451701A Expired ES451701A1 (es) 1975-09-22 1976-09-21 Procedimiento para la obtencion de y-lactonas de acidos 6 beta, 17-dihidroxi-7 alfa-(alcoxi inferior) -carbonil-3-oxo-17 alfa'pregn-4-eno-21-carboxilicos.

Country Status (21)

Country Link
US (1) US3972871A (es)
JP (1) JPS5248657A (es)
AT (1) AT352305B (es)
AU (1) AU499083B2 (es)
BE (1) BE846437A (es)
CA (1) CA1071620A (es)
CH (1) CH623337A5 (es)
DE (1) DE2642400A1 (es)
DK (1) DK138995B (es)
ES (1) ES451701A1 (es)
FI (1) FI55670C (es)
FR (1) FR2324309A1 (es)
GB (1) GB1520948A (es)
GR (1) GR61185B (es)
IE (1) IE44350B1 (es)
IL (1) IL50524A (es)
NL (1) NL7610477A (es)
NO (1) NO143910C (es)
NZ (1) NZ182127A (es)
PT (1) PT65616B (es)
SE (1) SE418295B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners
US4069219A (en) * 1976-12-27 1978-01-17 G. D. Searle & Co. 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters
JPS6063577U (ja) * 1983-10-07 1985-05-04 東レ株式会社 糸条のインタ−レ−ス装置
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US6887991B1 (en) * 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2237143A1 (de) * 1972-07-28 1974-02-14 Hoechst Ag Verfahren zur herstellung von beta(3-keto-7alpha-acetylthio-17beta-hydroxy4-androsten-17alpha-yl)-propionsaeuregamma-lacton und dessen 1-dehydro-derivat
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
PT65616A (en) 1976-10-01
FI55670C (fi) 1979-09-10
IL50524A0 (en) 1976-11-30
DK138995B (da) 1978-11-27
FR2324309B1 (es) 1979-03-02
IL50524A (en) 1979-12-30
IE44350B1 (en) 1981-11-04
NO143910B (no) 1981-01-26
DK425176A (es) 1977-03-23
GB1520948A (en) 1978-08-09
DK138995C (es) 1979-05-14
NO763231L (no) 1977-03-23
DE2642400A1 (de) 1977-03-24
GR61185B (en) 1978-10-05
AU499083B2 (en) 1979-04-05
JPS5248657A (en) 1977-04-18
NO143910C (no) 1981-06-03
ATA698476A (de) 1979-02-15
US3972871A (en) 1976-08-03
BE846437A (fr) 1977-03-22
AU1796276A (en) 1978-04-06
FR2324309A1 (fr) 1977-04-15
NZ182127A (en) 1978-11-13
CH623337A5 (es) 1981-05-29
CA1071620A (en) 1980-02-12
SE7610449L (sv) 1977-03-23
AT352305B (de) 1979-09-10
SE418295B (sv) 1981-05-18
IE44350L (en) 1977-03-22
PT65616B (en) 1978-04-05
NL7610477A (nl) 1977-03-24
FI55670B (fi) 1979-05-31
FI762690A (es) 1977-03-23

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