ES451542A1 - Acidic antibacterial agent - Google Patents

Acidic antibacterial agent

Info

Publication number
ES451542A1
ES451542A1 ES451542A ES451542A ES451542A1 ES 451542 A1 ES451542 A1 ES 451542A1 ES 451542 A ES451542 A ES 451542A ES 451542 A ES451542 A ES 451542A ES 451542 A1 ES451542 A1 ES 451542A1
Authority
ES
Spain
Prior art keywords
formula
nitro
see formula
compound
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES451542A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of ES451542A1 publication Critical patent/ES451542A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Procedure for the preparation of substituted 2-nitro-3-phenylbenzofuran compounds, of formula: **(See formula)** where X is halogen, lower alkyl, lower alkoxy, nitro, phenyl, cyano or trifluoromethyl, n is zero, one or two, R is a straight or branched chain alkylene of one to four carbon atoms or alkenylene of one to four carbon atoms, Y is methyl, methoxy, halogen or hydrogen, characterized in that it comprises: (A) directly nitrating position 2 of a compound of the formula: **(See formula)** (B) prepare an intermediate of formula: **(See formula)** where Q is bromine or iodine, and then selectively displacing the 2-halogen atom by a nitro group; (C) subjecting to acidic hydrolysis a compound of formula: **(See formula)** where A is cyano to a carboxylic ester group; or (D) reduce a compound of formula: **(See formula)** to 3-phenylbenzofuranaldehyde, followed by halogenation and filtration or direct nitration of the second of these to form 2-nitro-3-phenylbenzofuranaldehyde, react said product with acetic anhydride to form 2-nitro-3-phenylbenzofuranacrylic acid and, if you want to reduce the double bond in the side chain by catalytic hydrogenation to form 2-nitro-3-phenylbenzofuranpropionic acid. (Machine-translation by Google Translate, not legally binding)
ES451542A 1975-09-24 1976-09-15 Acidic antibacterial agent Expired ES451542A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61627775A 1975-09-24 1975-09-24

Publications (1)

Publication Number Publication Date
ES451542A1 true ES451542A1 (en) 1977-10-01

Family

ID=24468746

Family Applications (1)

Application Number Title Priority Date Filing Date
ES451542A Expired ES451542A1 (en) 1975-09-24 1976-09-15 Acidic antibacterial agent

Country Status (21)

Country Link
JP (1) JPS5239666A (en)
AR (1) AR215598A1 (en)
AU (1) AU1804276A (en)
BE (1) BE846502A (en)
CS (1) CS191319B2 (en)
DD (1) DD130786A5 (en)
DE (1) DE2642840A1 (en)
DK (1) DK413676A (en)
EG (1) EG12427A (en)
ES (1) ES451542A1 (en)
FI (1) FI762715A (en)
FR (1) FR2325369A1 (en)
IL (1) IL50543A0 (en)
IT (1) IT1070556B (en)
NL (1) NL7610166A (en)
NO (1) NO763144L (en)
OA (1) OA05441A (en)
PT (1) PT65632B (en)
SE (1) SE7610149L (en)
SU (1) SU692561A3 (en)
ZA (1) ZA765079B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4128659A (en) 1977-12-19 1978-12-05 Riker Laboratories, Inc. Antimicrobial polycyclic nitrofurans
US4143152A (en) 1977-12-19 1979-03-06 Riker Laboratories, Inc. Anti-microbial (2-nitro-3-phenyl benzofuranyl)-phenylalkanoic acids and derivatives
US4153721A (en) 1977-12-19 1979-05-08 Riker Laboratories, Inc. Derivatives of 2-nitrobenzofuran
US4154847A (en) 1978-06-26 1979-05-15 Riker Laboratories, Inc. Derivatives of 2-nitro-3-phenylbenzofurancarboxaldehydes
US4174403A (en) 1978-06-26 1979-11-13 Riker Laboratories, Inc. 5,6-Methylenedioxy-2-nitro-3-phenylbenzofurans
AU2020348754A1 (en) * 2019-09-16 2022-04-14 Koda Therapeutics, LLC Antimicrobial agents and compositions and uses thereof

Also Published As

Publication number Publication date
DD130786A5 (en) 1978-05-03
SE7610149L (en) 1977-03-25
DE2642840A1 (en) 1977-04-07
PT65632A (en) 1976-10-01
DK413676A (en) 1977-03-25
FI762715A (en) 1977-03-25
SU692561A3 (en) 1979-10-15
NL7610166A (en) 1977-03-28
FR2325369B1 (en) 1979-02-23
IT1070556B (en) 1985-03-29
JPS5239666A (en) 1977-03-28
NO763144L (en) 1977-03-25
OA05441A (en) 1981-03-31
CS191319B2 (en) 1979-06-29
ZA765079B (en) 1977-08-31
AR215598A1 (en) 1979-10-31
BE846502A (en) 1977-03-23
IL50543A0 (en) 1976-11-30
AU1804276A (en) 1978-04-06
PT65632B (en) 1978-04-05
EG12427A (en) 1979-03-31
FR2325369A1 (en) 1977-04-22

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