FR2325369A1 - (2)-Nitro (3)-phenyl benzofuran-alkanoic acids - with antibacterial, antifungal and antiprotozoal activity - Google Patents
(2)-Nitro (3)-phenyl benzofuran-alkanoic acids - with antibacterial, antifungal and antiprotozoal activityInfo
- Publication number
- FR2325369A1 FR2325369A1 FR7628662A FR7628662A FR2325369A1 FR 2325369 A1 FR2325369 A1 FR 2325369A1 FR 7628662 A FR7628662 A FR 7628662A FR 7628662 A FR7628662 A FR 7628662A FR 2325369 A1 FR2325369 A1 FR 2325369A1
- Authority
- FR
- France
- Prior art keywords
- antifungal
- nitro
- antibacterial
- phenyl
- alkanoic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
New benzofduran derivs. of formula (I) and their esters, amides, acids halides and salts: (where X is halogen, lower alkyl, lower alkoxy, NO2, Ph, CN or CF3; n = 0-2; R is 1-4C alkylene or 2-4C alkenylene; Y is Me, MeO, halogen or H). Cpds. (I) are antimicrobial agents, all with antibacterial activity and some also with antifungal and antiprotozoal (esp. trichomonacidal) activity. They can be used as medicaments, disinfectants and animal growth promoters. A typical cpds. is 2-nitro-3-phenyl-6-benzofuranacetic acid. In an example, this isd prepd. by nitrating 3-phenyl-6-benzofuranacetic acid.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61627775A | 1975-09-24 | 1975-09-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2325369A1 true FR2325369A1 (en) | 1977-04-22 |
FR2325369B1 FR2325369B1 (en) | 1979-02-23 |
Family
ID=24468746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7628662A Granted FR2325369A1 (en) | 1975-09-24 | 1976-09-23 | (2)-Nitro (3)-phenyl benzofuran-alkanoic acids - with antibacterial, antifungal and antiprotozoal activity |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS5239666A (en) |
AR (1) | AR215598A1 (en) |
AU (1) | AU1804276A (en) |
BE (1) | BE846502A (en) |
CS (1) | CS191319B2 (en) |
DD (1) | DD130786A5 (en) |
DE (1) | DE2642840A1 (en) |
DK (1) | DK413676A (en) |
EG (1) | EG12427A (en) |
ES (1) | ES451542A1 (en) |
FI (1) | FI762715A (en) |
FR (1) | FR2325369A1 (en) |
IL (1) | IL50543A0 (en) |
IT (1) | IT1070556B (en) |
NL (1) | NL7610166A (en) |
NO (1) | NO763144L (en) |
OA (1) | OA05441A (en) |
PT (1) | PT65632B (en) |
SE (1) | SE7610149L (en) |
SU (1) | SU692561A3 (en) |
ZA (1) | ZA765079B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021055506A1 (en) | 2019-09-16 | 2021-03-25 | Chemic Laboratories, Inc. | Antimicrobial agents and compositions and uses thereof |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4128659A (en) | 1977-12-19 | 1978-12-05 | Riker Laboratories, Inc. | Antimicrobial polycyclic nitrofurans |
US4143152A (en) | 1977-12-19 | 1979-03-06 | Riker Laboratories, Inc. | Anti-microbial (2-nitro-3-phenyl benzofuranyl)-phenylalkanoic acids and derivatives |
US4153721A (en) | 1977-12-19 | 1979-05-08 | Riker Laboratories, Inc. | Derivatives of 2-nitrobenzofuran |
US4174403A (en) | 1978-06-26 | 1979-11-13 | Riker Laboratories, Inc. | 5,6-Methylenedioxy-2-nitro-3-phenylbenzofurans |
US4154847A (en) | 1978-06-26 | 1979-05-15 | Riker Laboratories, Inc. | Derivatives of 2-nitro-3-phenylbenzofurancarboxaldehydes |
-
1976
- 1976-08-24 ZA ZA765079A patent/ZA765079B/en unknown
- 1976-09-14 SE SE7610149A patent/SE7610149L/en unknown
- 1976-09-14 NL NL7610166A patent/NL7610166A/en not_active Application Discontinuation
- 1976-09-14 DK DK413676A patent/DK413676A/en unknown
- 1976-09-14 NO NO763144A patent/NO763144L/en unknown
- 1976-09-15 ES ES451542A patent/ES451542A1/en not_active Expired
- 1976-09-23 IL IL50543A patent/IL50543A0/en unknown
- 1976-09-23 PT PT65632A patent/PT65632B/en unknown
- 1976-09-23 AU AU18042/76A patent/AU1804276A/en not_active Expired
- 1976-09-23 DE DE19762642840 patent/DE2642840A1/en active Pending
- 1976-09-23 AR AR264829A patent/AR215598A1/en active
- 1976-09-23 IT IT27552/76A patent/IT1070556B/en active
- 1976-09-23 FI FI762715A patent/FI762715A/fi not_active Application Discontinuation
- 1976-09-23 CS CS766174A patent/CS191319B2/en unknown
- 1976-09-23 OA OA55942A patent/OA05441A/en unknown
- 1976-09-23 SU SU762405875A patent/SU692561A3/en active
- 1976-09-23 DD DD7600194956A patent/DD130786A5/en unknown
- 1976-09-23 FR FR7628662A patent/FR2325369A1/en active Granted
- 1976-09-23 BE BE170876A patent/BE846502A/en unknown
- 1976-09-24 JP JP51114551A patent/JPS5239666A/en active Pending
- 1976-09-28 EG EG592/76A patent/EG12427A/en active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021055506A1 (en) | 2019-09-16 | 2021-03-25 | Chemic Laboratories, Inc. | Antimicrobial agents and compositions and uses thereof |
EP4031128A4 (en) * | 2019-09-16 | 2023-12-13 | Koda Therapeutics, LLC | Antimicrobial agents and compositions and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
EG12427A (en) | 1979-03-31 |
AR215598A1 (en) | 1979-10-31 |
JPS5239666A (en) | 1977-03-28 |
ES451542A1 (en) | 1977-10-01 |
IT1070556B (en) | 1985-03-29 |
SU692561A3 (en) | 1979-10-15 |
ZA765079B (en) | 1977-08-31 |
NL7610166A (en) | 1977-03-28 |
DD130786A5 (en) | 1978-05-03 |
CS191319B2 (en) | 1979-06-29 |
FR2325369B1 (en) | 1979-02-23 |
BE846502A (en) | 1977-03-23 |
PT65632A (en) | 1976-10-01 |
OA05441A (en) | 1981-03-31 |
NO763144L (en) | 1977-03-25 |
SE7610149L (en) | 1977-03-25 |
DK413676A (en) | 1977-03-25 |
PT65632B (en) | 1978-04-05 |
AU1804276A (en) | 1978-04-06 |
FI762715A (en) | 1977-03-25 |
IL50543A0 (en) | 1976-11-30 |
DE2642840A1 (en) | 1977-04-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |