ES446092A1 - Procedure for the obtaining of piperidine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining piperidine derivatives of general formula I **(See formula)** wherein it means hydrogen, an aliphatic hydrocarbon residue with 1-12 or a cycloaliphatic hydrocarbon residue with 3-12 carbon atoms, the residues of which are substituted by hydroxyl groups or an oxo residue and/or may be interrupted by oxygen, or a residue phenyl- (lower alkyl), in whose benzene ring at least three hydrogen atoms may be substituted by substituents of the halogen compound group up to atomic number 35, lower alkyl and lower alkoxy groups, of the methylenedioxy group and of the trifluoromethyl group and whose chain Lower alkyl, on its carbon atoms not directly bonded to the nitrogen atom of the ring, may be substituted by an oxo moiety or a hydroxyl group, or a cinnamyl moiety, if appropriate correspondingly substituted on the benzene ring, but which cannot be a methyl group in the case that A means the ethylene moiety and B means the methylene moiety and at the same time R2, R3, R4 and R5 mean in each case hi endogenous, R2 means hydrogen or a lower alkyl group, R3 and R4, independent of each other, mean hydrogen, lower alkyl or lower alkoxy groups, halogen atoms up to atomic number 35, benzyloxy or hydroxyl groups, and R3 can also mean a trifluoromethyl group, a 1-hydroxyalkyl or lower alk-1-enyl group, a 1-hydroxy-cycloalkyl, 1-cycloalk-1-enyl or cycloalkyl group, each with 5-8 carbon atoms, or R3 and R4 together the trimethylene or tetramethylene moiety or correspondingly a condensed benzene ring, the 1,3-butadienylene moiety, R5 signifies hydrogen or an alkyl group with a maximum of 4 carbon atoms, and A and B signify bivalent, aliphatic, saturated hydrocarbon moieties or one of these symbols also the direct bond, showing A and B together always 3 chain members and together with R5 in total at most 9 carbon atoms, and their addition salts with inorganic and organic acids, characterized in that a compound of general formula II **(See formula)** where R6 and R7 signify hydrogen or lower alkyl, R2, R3 and R4, have the meaning indicated under formula I, or a compound of general formula III **(See formula)** where R1, R2, R3, R4, R5, A and B have the meanings indicated under formula I, the corresponding piperidino compound is catalytically hydrogenated, and if desired, a compound obtained of general formula I is transformed into an addition salt, with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)