ES446091A1 - Procedure for the obtaining of derivatives of tetrahidropiridina. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining tetrahydropyridine and piperidine derivatives of general formula I **(See formula)** wherein it means an aliphatic hydrocarbon residue with 1-12 or a cycloaliphatic hydrocarbon residue with 3-12 carbon atoms, the residues of which are substituted by hydroxyl groups or an oxo residue and/or may be interrupted by oxygen, or a phenyl residue. (lower alkyl), in whose benzene ring at least three hydrogen atoms may be substituted by substituents of the halogen compound group up to atomic number 35, lower alkyl and lower alkoxy groups, of the methylenedioxy group and of the trifluoromethyl group and whose lower chain, at their carbon atoms not directly bonded to the nitrogen atom of the ring, they may be substituted by an oxo moiety or a hydroxyl group, or a cinnamyl moiety, if appropriate correspondingly substituted on the benzene ring, but which cannot be a group methyl in the case that A means the ethylene moiety and B means the methylene moiety and at the same time R2, R3, R4 and R5 mean in each case hydrogen, R2 means C to hydrogen or a lower alkyl group, R3 and R4, independent of each other, mean hydrogen, lower alkyl or lower alkoxy groups, halogen atoms up to atomic number 35, benzyloxy or hydroxyl groups, and R3 can also mean a trifluoromethyl group, a group 1-hydroxyalkyl lower or lower alk-1-enyl, a 1-hydroxycycloalkyl, 1-cyclo-alk-1-enyl or cycloalkyl group, each having 5-8 carbon atoms, or R3 and R4 together the trimethylene moiety or tetramethylene or, correspondingly a condensed benzene ring, the 1,3-butadienylene residue, R5 signifies hydrogen or an alkyl group with a maximum of 4 carbon atoms, and A and B signify bivalent, aliphatic, saturated hydrocarbon residues or one of these symbols also the direct bond, showing A and B together always 3 chain members and together with R5 in total a maximum of 9 carbon atoms, X and Y, in each case, signify hydrogen or together an additional bond, and their addition salts with inorganic acids cos and organic, characterized in that a compound of general formula II **(See formula)** where Z- means a monovalent anion or the normal equivalent of a polyvalent anion, R6 and R7 signify hydrogen or alkyl moieties, together with a maximum of 6 carbon atoms and R1 R2, R3 and R4 have the meaning indicated under formula I, partially reduces the corresponding compound of general formula I, and, if desired, a compound obtained of general formula I is transformed into an addition salt with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)