ES445200A1 - Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES445200A1
ES445200A1 ES445200A ES445200A ES445200A1 ES 445200 A1 ES445200 A1 ES 445200A1 ES 445200 A ES445200 A ES 445200A ES 445200 A ES445200 A ES 445200A ES 445200 A1 ES445200 A1 ES 445200A1
Authority
ES
Spain
Prior art keywords
formula
signify
compound
group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES445200A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES445200A1 publication Critical patent/ES445200A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/081,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of new analog compounds of prostanoic acids of the formula I **(See formula)** in which: R1 and R2 together signify oxygen or in each case hydrogen or a hydroxyl group, R1 and R2 being different; R3 and R4 each signify hydrogen or a hydroxyl group, R3 and R4 being different; and R5 signifies an aliphatic hydrocarbon radical of 3 to 10 carbon atoms, saturated or unsaturated, branched or unbranched, or an aralkoyl radical of 7 to 11 carbon atoms; as well as the physiologically compatible salts of the compounds of the formula I with organic and inorganic bases, and of their esters with aliphatic, cycloaliphatic and araliphatic alcohols with 1 to 8 carbon atoms in the ester portion, characterized in that it is separated by acid hydrolysis the hydroxyl protecting group in a compound of formula VII **(See formula)** wherein R has the same meanings as mentioned on the occasion of formula I in claim 1; R6 and R7 are different and each signify hydrogen or a group **(See formula)** wherein R8 and R9 signify C 1 -C4 alcohol and R10 signify hydrogen or C 1 -C 4 alcohol; or R8 and R9 are together part of a five or six membered heterocyclic ring; X stands for oxygen or sulfur; and Y means a single bond, a group -CH2- or a group (see formula) obtaining an alcohol of formula VIII **(See formula)** wherein R3 R4 and R5 have the same meanings as mentioned on the occasion of formula I in claim 1, and X as well as Y have the same meanings as in formula VII, and then the Celtic grouping in a compound of the formula VIII, or the separation of both protecting groups in a compound of the formula VII is carried out in a single step and eventually the compound thus obtained of the formula I is reduced, where R1 and R2 together signify oxygen, to forming a compound of formula I, in which R1 and R2 signify hydrogen or hydroxide and R1 is different from R2, and if desired the compounds of formula I are transformed into physiologically compatible salts or esters. (Machine-translation by Google Translate, not legally binding)
ES445200A 1975-02-21 1976-02-16 Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding) Expired ES445200A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752507425 DE2507425A1 (en) 1975-02-21 1975-02-21 ANALOGS OF PROSTANIC ACIDS AND THE PROCESS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
ES445200A1 true ES445200A1 (en) 1977-06-01

Family

ID=5939418

Family Applications (1)

Application Number Title Priority Date Filing Date
ES445200A Expired ES445200A1 (en) 1975-02-21 1976-02-16 Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
AU (1) AU1125476A (en)
BE (1) BE838832A (en)
DE (1) DE2507425A1 (en)
DK (1) DK70476A (en)
ES (1) ES445200A1 (en)
FR (1) FR2301240A1 (en)
GR (1) GR60029B (en)
LU (1) LU74383A1 (en)
NL (1) NL7601553A (en)
SE (1) SE7602004L (en)
ZA (1) ZA761019B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201873A (en) * 1975-09-17 1980-05-06 The Upjohn Company 9-Deoxy-9,10-didehydro-PGD2 analogs
SE9803107D0 (en) * 1998-09-14 1998-09-14 Astra Pharma Prod Novel Compunds
GB0523435D0 (en) * 2005-11-17 2005-12-28 Sinclair Pharmaceuticals Ltd Process

Also Published As

Publication number Publication date
BE838832A (en) 1976-08-23
AU1125476A (en) 1977-08-25
NL7601553A (en) 1976-08-24
SE7602004L (en) 1976-08-23
GR60029B (en) 1978-03-31
ZA761019B (en) 1977-01-26
FR2301240A1 (en) 1976-09-17
LU74383A1 (en) 1977-01-06
DK70476A (en) 1976-08-22
DE2507425A1 (en) 1976-09-02

Similar Documents

Publication Publication Date Title
ES443524A1 (en) Procedure for the preparation of analogous compounds of prostanic acids that do not exist in nature. (Machine-translation by Google Translate, not legally binding)
ES470861A1 (en) Novel derivatives of substituted 2-benzoyl-4-chloro-glycinanilides, their preparation and their use as medicines.
ES409190A1 (en) Citric acid derivatives
ES445200A1 (en) Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding)
ES316855A1 (en) Procedure for preparing chrysanthemic acid esters (Machine-translation by Google Translate, not legally binding)
ES434304A1 (en) Esters of dihydroapovincaminic acid
ES453305A1 (en) Amino acid derivatives
ES429959A1 (en) Procedure for the preparation of new analogosous compounds of prostanic acids, not present in nature (Machine-translation by Google Translate, not legally binding)
ES442022A1 (en) Phenylpropanolamines
ES441775A1 (en) Anthraquinone dyes
ES406129A1 (en) Procedure for the preparation of 4 - (4 - bifenilil) - butirrics and their steres. (Machine-translation by Google Translate, not legally binding)
ES405048A1 (en) Phenothiazine derivatives
ES417883A1 (en) Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
ES438255A1 (en) Shinki 22 fueniruarukiruesuterunoseiho
ES325387A1 (en) Procedure for preparing insatured carboxylic acids. (Machine-translation by Google Translate, not legally binding)
FR2451362B1 (en)
ES394667A1 (en) Preparation of prostanoic acid derivatives
ES450472A1 (en) Benzoyl pyrazole 5-acetic acid derivatives useful as uricosurucs
GB837879A (en) Reserpic acid esters and salts thereof and process for their manufacture
ES453836A1 (en) Procedure for the preparation of derivatives of 5-sulfamilbenzoico acid substituted with heterociclic radicals. (Machine-translation by Google Translate, not legally binding)
ES423976A1 (en) Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)
ES444834A1 (en) Procedure for the preparation of semicarbazides. (Machine-translation by Google Translate, not legally binding)
ES341697A1 (en) Procedure for the production of new dihidro-1-piridil-isoquinoleinas. (Machine-translation by Google Translate, not legally binding)
ES394660A1 (en) Procedure for preparation of espiroheterociclanic compounds that bring a phenylacetic group. (Machine-translation by Google Translate, not legally binding)
ES446321A1 (en) Esters of theophyllinylacetic acid