ES445200A1 - Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES445200A1 ES445200A1 ES445200A ES445200A ES445200A1 ES 445200 A1 ES445200 A1 ES 445200A1 ES 445200 A ES445200 A ES 445200A ES 445200 A ES445200 A ES 445200A ES 445200 A1 ES445200 A1 ES 445200A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- signify
- compound
- group
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of new analog compounds of prostanoic acids of the formula I **(See formula)** in which: R1 and R2 together signify oxygen or in each case hydrogen or a hydroxyl group, R1 and R2 being different; R3 and R4 each signify hydrogen or a hydroxyl group, R3 and R4 being different; and R5 signifies an aliphatic hydrocarbon radical of 3 to 10 carbon atoms, saturated or unsaturated, branched or unbranched, or an aralkoyl radical of 7 to 11 carbon atoms; as well as the physiologically compatible salts of the compounds of the formula I with organic and inorganic bases, and of their esters with aliphatic, cycloaliphatic and araliphatic alcohols with 1 to 8 carbon atoms in the ester portion, characterized in that it is separated by acid hydrolysis the hydroxyl protecting group in a compound of formula VII **(See formula)** wherein R has the same meanings as mentioned on the occasion of formula I in claim 1; R6 and R7 are different and each signify hydrogen or a group **(See formula)** wherein R8 and R9 signify C 1 -C4 alcohol and R10 signify hydrogen or C 1 -C 4 alcohol; or R8 and R9 are together part of a five or six membered heterocyclic ring; X stands for oxygen or sulfur; and Y means a single bond, a group -CH2- or a group (see formula) obtaining an alcohol of formula VIII **(See formula)** wherein R3 R4 and R5 have the same meanings as mentioned on the occasion of formula I in claim 1, and X as well as Y have the same meanings as in formula VII, and then the Celtic grouping in a compound of the formula VIII, or the separation of both protecting groups in a compound of the formula VII is carried out in a single step and eventually the compound thus obtained of the formula I is reduced, where R1 and R2 together signify oxygen, to forming a compound of formula I, in which R1 and R2 signify hydrogen or hydroxide and R1 is different from R2, and if desired the compounds of formula I are transformed into physiologically compatible salts or esters. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752507425 DE2507425A1 (en) | 1975-02-21 | 1975-02-21 | ANALOGS OF PROSTANIC ACIDS AND THE PROCESS FOR THEIR PRODUCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES445200A1 true ES445200A1 (en) | 1977-06-01 |
Family
ID=5939418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES445200A Expired ES445200A1 (en) | 1975-02-21 | 1976-02-16 | Procedure for the preparation of new analogy compounds of prostanic acids. (Machine-translation by Google Translate, not legally binding) |
Country Status (11)
| Country | Link |
|---|---|
| AU (1) | AU1125476A (en) |
| BE (1) | BE838832A (en) |
| DE (1) | DE2507425A1 (en) |
| DK (1) | DK70476A (en) |
| ES (1) | ES445200A1 (en) |
| FR (1) | FR2301240A1 (en) |
| GR (1) | GR60029B (en) |
| LU (1) | LU74383A1 (en) |
| NL (1) | NL7601553A (en) |
| SE (1) | SE7602004L (en) |
| ZA (1) | ZA761019B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201873A (en) * | 1975-09-17 | 1980-05-06 | The Upjohn Company | 9-Deoxy-9,10-didehydro-PGD2 analogs |
| SE9803107D0 (en) * | 1998-09-14 | 1998-09-14 | Astra Pharma Prod | Novel Compunds |
| GB0523435D0 (en) * | 2005-11-17 | 2005-12-28 | Sinclair Pharmaceuticals Ltd | Process |
-
1975
- 1975-02-21 DE DE19752507425 patent/DE2507425A1/en active Pending
-
1976
- 1976-02-16 ES ES445200A patent/ES445200A1/en not_active Expired
- 1976-02-16 NL NL7601553A patent/NL7601553A/en unknown
- 1976-02-19 LU LU74383A patent/LU74383A1/xx unknown
- 1976-02-19 GR GR50100A patent/GR60029B/en unknown
- 1976-02-19 AU AU11254/76A patent/AU1125476A/en not_active Expired
- 1976-02-20 ZA ZA1019A patent/ZA761019B/en unknown
- 1976-02-20 DK DK70476*#A patent/DK70476A/en unknown
- 1976-02-20 SE SE7602004A patent/SE7602004L/en unknown
- 1976-02-23 BE BE164542A patent/BE838832A/en unknown
- 1976-02-23 FR FR7604889A patent/FR2301240A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU1125476A (en) | 1977-08-25 |
| NL7601553A (en) | 1976-08-24 |
| FR2301240A1 (en) | 1976-09-17 |
| DE2507425A1 (en) | 1976-09-02 |
| ZA761019B (en) | 1977-01-26 |
| BE838832A (en) | 1976-08-23 |
| GR60029B (en) | 1978-03-31 |
| DK70476A (en) | 1976-08-22 |
| LU74383A1 (en) | 1977-01-06 |
| SE7602004L (en) | 1976-08-23 |
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